Sustainable synthesis of structures containing quinoxaline-pseudopeptide-triazole pharmacophores<i>via</i>a one-pot six-component reaction

Farhid, Hassan; Araghi, Hanieh Mohammadi; Shaabani, Ahmad; Notash, Behrouz

doi:10.1039/d2nj06207k

New J. Chem.

2023

DOI: 10.1039/d2nj06207k

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Sustainable synthesis of structures containing quinoxaline-pseudopeptide-triazole pharmacophoresviaa one-pot six-component reaction

Hassan Farhid

Hanieh Mohammadi Araghi

Ahmad Shaabani

et al.

Abstract: A sustainable, economical, and straightforward synthetic route based on the higher-order multicomponent reactions (MCRs) approach for the unification of biologically significant quinoxaline-pseudopeptide-triazole pharmacophores in a sole structure, is developed. The...

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Cited by 2 publications

References 87 publications

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A Sonochemical and Mechanochemical One‐Pot Multicomponent/Click Coupling Strategy for the Sustainable Synthesis of Bis‐Heterocyclic Drug Scaffolds

Rentería‐Gómez,

Calderón‐Rangel,

Corona‐Díaz

et al. 2024

ChemPlusChem

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Bis‐heterocycles were synthesized via a consecutive one‐pot process by a Groebke‐Blackburn‐Bienaymé reaction (GBB‐3CR) followed by Copper‐catalyzed Alkyne‐Azide Cycloaddition (CuAAC) assisted by alternative sustainable energies (ASE) such as ultrasound irradiation (USI) and mechanical. These efficient and convergent strategies allowed the in situ generation of complex azides functionalized with imidazo[1,2‐a]pyridines (IMPs), which was used as a synthetic platform. The target molecules contain two privileged scaffolds in medicinal chemistry: IMPs and the heterocyclic bioisostere of trans‐amide bond, the 1,4‐disubstituted 1H‐1,2,3‐triazoles (1,4‐DS‐1,2,3‐Ts).

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A Sonochemical and Mechanochemical One‐Pot Multicomponent/Click Coupling Strategy for the Sustainable Synthesis of Bis‐Heterocyclic Drug Scaffolds

Rentería‐Gómez,

Calderón‐Rangel,

Corona‐Díaz

et al. 2024

ChemPlusChem

View full text Add to dashboard Cite

show abstract

Straightforward synthesis of quinoxaline-furan bis-heterocyclic structures via a multicomponent reaction

Farhid

Araghi

Shaabani

et al. 2023

Journal of Molecular Structure

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Sustainable synthesis of structures containing quinoxaline-pseudopeptide-triazole pharmacophoresviaa one-pot six-component reaction

Abstract: A sustainable, economical, and straightforward synthetic route based on the higher-order multicomponent reactions (MCRs) approach for the unification of biologically significant quinoxaline-pseudopeptide-triazole pharmacophores in a sole structure, is developed. The...

Cited by 2 publications

References 87 publications

A Sonochemical and Mechanochemical One‐Pot Multicomponent/Click Coupling Strategy for the Sustainable Synthesis of Bis‐Heterocyclic Drug Scaffolds

A Sonochemical and Mechanochemical One‐Pot Multicomponent/Click Coupling Strategy for the Sustainable Synthesis of Bis‐Heterocyclic Drug Scaffolds

Straightforward synthesis of quinoxaline-furan bis-heterocyclic structures via a multicomponent reaction

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