Planning and developing urban tourism destinations must encompass landscape optimization to achieve healthy urban ecosystems, as well as for evolution sustainability. This study explored sustainable landscape planning by examining the optimization of landscape spatial distribution in an urban tourism destination-Nanjing, China-using an integrated approach that included remote sensing (RS), geographic information system (GIS), and landscape metrics in the context of an urban tourism destination evolution model. Least-cost modeling in GIS was also used to optimize decision-making from an ecological perspective. The results indicated that landscapes were more homogenous, fragmented, and less connected. Except for the eastern area, the landscape evolution showed characteristics of both degeneration and growth. A complete greenway network including sources, greenways, and nodes were constructed, and an increase in natural landscapes was strongly recommended. The findings provide geographic insights for sustainable urban tourism planning and development via comprehensive methodological applications.