The topic of sustainable mobility is now a priority at the urban level. Today’s cities are often very busy, polluted, and dangerous. Therefore, to encourage sustainable mobility is important; it brings territorial development, environment, health, society, and economy benefits. The corona virus disease-19 (COVID) emergency, which occurred at the beginning of 2020, highlighted the already critical situation in many cities and how our mobility habits were not, even before, so sustainable. Within sustainable mobility, the concept of safety and security is important to consider. In the literature, safe mobility is often associated with the theme of accidents. The pandemic has highlighted the need to consider safety also from a health point of view. Municipalities, as known, also according to European guidelines, have a specific tool at their disposal to promote sustainable mobility: the Sustainable Urban Mobility Plan (SUMP). This paper intends to propose a methodological approach aimed at integrating the health security aspect in the SUMP. In this research, in order to promote safe mobility, different aspects were considered: accidents, risk perception, and health emergencies. For each aspect, specific indicators and good practices were proposed for the achievement and monitoring of the expected results. The paper refers to the European context with particular attention to Italy; La Spezia was chosen as a case study.