Sustainable use of mangroves as sources of valuable medicinal compounds: Species identification, propagation and secondary metabolite composition

Glasenapp, Yvana; Korth, I.; Nguyen, Xuan-Vy; Papenbrock, Jutta

doi:10.1016/j.sajb.2018.11.020

Cited by 20 publications

(19 citation statements)

References 48 publications

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“…Adhesion has been reduced in all the models except for E. coli , where adhesion was promoted in the presence of the B. cylindrica extract. Glasenapp et al reported an inhibitory activity of tannins extracted from L. racemosa against C. albicans cell adhesion [21]. The tannin casuarinin was also present in the crude extract used in this study, and was therefore likely important in the observed reduction of biofilm cell adhesion.…”

Section: Discussionmentioning

confidence: 72%

“…The signal of methyl gallate was likely a breakdown product from epigallocatechin 3,5-digallate. The tannin casuarinin was identified by the presence of the double-charged ion at m/z 467.03, and its fragments were compared to the data measured by Glasenapp et al [21].…”

Section: Resultsmentioning

confidence: 99%

“…Gaertn. and B. cylindrica (L.) Blume were grown in the greenhouse of the Institute of Botany, Germany, so that fresh plant material has been always available during this research [21]. The leaves of adult plants were collected in February 2016, directly frozen in liquid nitrogen, and ground to a fine powder.…”

Section: Methodsmentioning

confidence: 99%

“…An advantage of using the extracts is their putative additive and synergistic activity, as they can act on multiple targets, which is an interesting strategy when dealing with the complex biofilm formation phenomenon, as several pathways are involved [20]. Mangroves were chosen as they have already been proven to be promising in interfering with planktonic and sessile bacteria and fungi [21,22].…”

Section: Introductionmentioning

confidence: 99%

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Promoting Beneficial and Inhibiting Undesirable Biofilm Formation with Mangrove Extracts

Glasenapp

Cattò

Villa

et al. 2019

IJMS

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The extracts of two mangrove species, Bruguiera cylindrica and Laguncularia racemosa, have been analyzed at sub-lethal concentrations for their potential to modulate biofilm cycles (i.e., adhesion, maturation, and detachment) on a bacterium, yeast, and filamentous fungus. Methanolic leaf extracts were also characterized, and MS/MS analysis has been used to identify the major compounds. In this study, we showed the following. (i) Adhesion was reduced up to 85.4% in all the models except for E. coli, where adhesion was promoted up to 5.10-fold. (ii) Both the sum and ratio of extracellular polysaccharides and proteins in mature biofilm were increased up to 2.5-fold and 2.6-fold in comparison to the negative control, respectively. Additionally, a shift toward a major production of exopolysaccharides was found coupled with a major production of both intracellular and extracellular reactive oxygen species. (iii) Lastly, detachment was generally promoted. In general, the L. racemosa extract had a higher bioactivity at lower concentrations than the B. cylindrica extract. Overall, our data showed a reduction in cells/conidia adhesion under B. cylindrica and L. racemosa exposure, followed by an increase of exopolysaccharides during biofilm maturation and a variable effect on biofilm dispersal. In conclusion, extracts either inhibited or enhanced biofilm development, and this effect depended on both the microbial taxon and biofilm formation step.

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Section: Discussionmentioning

confidence: 72%

Section: Resultsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Promoting Beneficial and Inhibiting Undesirable Biofilm Formation with Mangrove Extracts

Glasenapp

Cattò

Villa

et al. 2019

IJMS

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“…In particular, the relationships among major evolutionary lineages within the family (e.g., the four subfamilies) as well as the generic limits within the largest subfamily (Acanthoideae) remain unresolved (e.g., McDade et al., ). Furthermore, the phylogenetic relationships in several smaller clades are currently not well understood (e.g., in Avicennia L. [Glasenapp et al., ], Barleria L. [Darbyshire et al., ], Dyschoriste Nees [Chumchim et al., ], Thunbergioideae T. Anderson [Borg et al., ], Ruellia L. [Tripp et al., ]). In addition to this obstacle, the rooting of the Acanthaceae phylogeny is uncertain, as interfamilial relationships in Lamiales remain elusive (Schäferhoff et al., ; Refulio‐Rodriguez and Olmstead, ; Stull et al., ; Wikström et al., ; Chase et al., ; Sarzi et al., ; Xu et al., ).…”

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confidence: 99%

Orthologous nuclear markers and new transcriptomes that broadly cover the phylogenetic diversity of Acanthaceae

et al. 2019

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Premise Information on orthologous groups of genes, their sequence variability, and annotation is required for project design in phylogenetic reconstruction. This resource is unavailable for the flowering plant family Acanthaceae (>4000 species). Methods We compared transcriptome sequences spanning the extant diversity of Acanthaceae in order to provide a set of orthologous low‐copy nuclear genes and assess their utility for reconstructing phylogenetic relationships within this group of plants. Results We present new transcriptome assemblies for eight species representing all major clades of Acanthaceae. The assemblies of five of these species are entirely based on new sequence data. Of these five species, three are from subfamilies for which no genomic resources were previously available (Nelsonioideae and Thunbergioideae). These five new transcriptomes are more complete than all others from public databases. Furthermore, we provide alignments with sequence information, annotation, and statistics for potential phylogenetic utility of 1619 orthologous low‐copy nuclear markers. Discussion Our method of inferring assemblies from multiple pooled tissue samples delivers more complete transcriptomes than any available ones from Acanthaceae. We make available to the community new resources (e.g., sequence information, variability, and annotation of orthologous low‐copy nuclear genes) that will help phylogenetic reconstruction in Acanthaceae.

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Anti‐Adhesion Activity of Tannins Isolated from the Mangrove Laguncularia racemosa

Glasenapp

Lucas

Wöltje

et al. 2019

Chemistry & Biodiversity

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In the search of new compounds with biofilm‐inhibiting properties, mangroves with their richness of secondary metabolites can be a valuable resource. Crude methanolic leaf extracts from the mangrove Laguncularia racemosa enriched in phenolic substances cause a reduction in initial cell adhesion of Candida glabrata and Candida albicans, but not on Escherichia coli. LC/MS‐guided fractionation of the phenolic compounds resulted in 19 fractions, of which ten were analyzed for their bioactivity against cell adhesion. Effects on cell adhesion and planktonic growth of Escherichia coli, Candida glabrata and Candida albicans were measured in 96‐well microtiter plates in the presence of 0.2 mg ml−1 of the isolated fractions. Two fractions caused a reduction of cell adhesion of Candida albicans. These fractions containing bioactive compounds were analyzed by LC/MS and NMR spectroscopy. Casuarinin and digalloyl‐hexahydroxydiphenoyl‐glucose were identified in the active fractions, in addition to three signals of ellagitannins. These results indicate a specific mode of action of hydrolysable tannins against cell adhesion of Candida albicans, which needs to be further analyzed.

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Sustainable use of mangroves as sources of valuable medicinal compounds: Species identification, propagation and secondary metabolite composition

Cited by 20 publications

References 48 publications

Promoting Beneficial and Inhibiting Undesirable Biofilm Formation with Mangrove Extracts

Promoting Beneficial and Inhibiting Undesirable Biofilm Formation with Mangrove Extracts

Orthologous nuclear markers and new transcriptomes that broadly cover the phylogenetic diversity of Acanthaceae

Anti‐Adhesion Activity of Tannins Isolated from the Mangrove Laguncularia racemosa

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