Objective: The aim of this study is to observe the effects of Quality Control Circle (QCC) in clinical pain care. Methods: A total of 140 patients admitted in our hospital from September 2016 to September 2017 were selected and divided into the control group (n=70) and observation group (n=70) by the number table method. These patients had varying degrees of pain. The control group was offered with conventional clinical nursing, whereas the observation group subjected to the QCC. The two groups were compared with respect to pain improvement, nursing satisfaction, nursing quality, and work efficiency. Results: With respect to number of pain cases, the observation group has significantly fewer cases of moderate and severe pain than the control group. There is statistically significant difference between the two groups (P<0.05). The observation group achieves higher rate of pain knowledge assessment of nurses, positive pain informing rate of patients, rate of satisfying pain nursing records, timeliness with regard to the handling of patients with pain score ≥ 4, and overall satisfaction of patients with respect to pain management than the control group (P<0.05). The control group was inferior to the observation group with respect to teamwork, confidence, enthusiasm, and communication and cooperation scores (P<0.05). Conclusions: In clinical pain nursing, QCC is conducive to pain alleviation, increases nursing satisfaction and work efficiency, and improves nursing quality. Thus, it is worthy of clinical use and positive promotion.