Sustained and Microenvironment-Accelerated Release of Minocycline from Alginate Injectable Hydrogel for Bacteria-Infected Wound Healing

Abstract

During wound healing, bacterial infection is one of the main limiting factors for the desired efficiency. Wound dressing-mediated antibiotics therapies could overcome this problem to a great extent due to sustained drug release and controllable dose. Here, we designed a kind of alginate injectable hydrogel loaded with minocycline (SA@MC) as a dressing for staphylococcus aureus-infected wound healing. SA@MC hydrogel possessed good injectability and can be injected by syringes. MC participated in the gel formation, causing the microstructure change based on the morphology characterization. The element mapping and FT-IR spectra further confirmed the successful loading of MC in SA hydrogel. Interestingly, MC was released more efficiently in a weakly alkaline condition (pH 7–8) than in a weakly acidic condition (pH 4–6) from SA@MC injectable hydrogel, which means that there is an accelerated release to respond to the weakly alkaline wound microenvironment. Meanwhile, SA@MC injectable hydrogel had high biocompatibility and excellent antibacterial activity due to the sustained release of MC. Further, in vivo experiment results demonstrated that SA@MC injectable hydrogel promoted staphylococcus aureus-infected wound healing efficiently. In summary, the injectable composite hydrogel can serve as an ideal dressing to prevent bacterial infection and promote wound healing.

Recent Reports on Polysaccharide-Based Materials for Drug Delivery

“…Hydrogel formulation [ 15 , 16 , 17 ], capable of absorbing many fluids, is often used as a carrier of different active agents. Recently, they have been successfully used, for example, for cancer therapy [ 18 ], optic neuropathy [ 19 ], or wound healing [ 20 ]. Szekalska et al [ 21 ] prepared ALG hydrogel as a carrier of cynaroside with anti-inflammatory and anti-allergic activities.…”

Nanocatalytic Hydrogel with Rapid Photodisinfection and Robust Adhesion for Fortified Cutaneous Regeneration

“…Hypoxia in the deep infection microenvironment (IME) can greatly reduce PDT efficiency. 14,15 Hence, it is necessary to improve the efficacy of phototherapy in an IME-induced hypoxic microenvironment. Among them, photothermal agents (PTA) are particularly important.…”

“…Nevertheless, phototherapy has inevitable drawbacks. Hypoxia in the deep infection microenvironment (IME) can greatly reduce PDT efficiency. , Hence, it is necessary to improve the efficacy of phototherapy in an IME-induced hypoxic microenvironment. Among them, photothermal agents (PTA) are particularly important. , Semiconductor materials have excellent photothermal and photodynamic conversion properties, so they are ideal candidates for photothermal agents.…”

Ga3+ loaded radiation crosslinked gel-Alg-CMC hydrogels for promoting diabetic wound healing

“…14 Alginate can improve the hydrophilic nature of trauma dressings, create a moist trauma microenvironment, and remove trauma exudates. 15,16 In addition, carboxymethyl cellulose (CMC) contains a large number of carboxymethyl groups, and its widespread use as a natural component of hydrogels is mainly due to this characteristic. 17,18 Gelatin and alginate induce platelet activation for wound hemostasis, and CMC reduces the uptake of exudates during skin epithelialization.…”