Sustained antibacterial effect of a hand rub gel incorporating chlorhexdine-loaded nanocapsules (Nanochlorex®)

Nhung, Dang Thi Tuyet; Freydière, Anne-Marie; Constant, H.; Falson, Françoise; Pirot, Fabrice

doi:10.1016/j.ijpharm.2006.10.017

Cited by 32 publications

(13 citation statements)

References 26 publications

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“…[40,41] Recent reports suggest than hand rubs other than alcohol can also be effective in eliminating microorganisms. [42] More data are required before conclusions can be drawn.…”

Section: Products For Hand Hygienementioning

confidence: 99%

Prevention and control of health care-associated infections through improved hand hygiene

Mathai

Allegranzi

Kilpatrick

et al. 2010

Indian Journal of Medical Microbiology

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Determined actions are required to address the burden due to health care-associated infections worldwide and improve patient safety. Improving hand hygiene among health care workers is an essential intervention to achieve these goals. The World Health Organization (WHO) First Global Patient Safety Challenge, Clean Care is Safer Care, pledged to tackle the problem of health care-associated infection at its launch in 2005 and has elaborated a comprehensive set of guidelines for use in both developed and developing countries worldwide. The final version of the WHO Guidelines on Hand Hygiene in Health Care was issued in March 2009 and includes recommendations on indications, techniques, and products for hand hygiene. In this review, we discuss the role of hands in the transmission of health care-associated infection, the benefits of improved compliance with hand hygiene, and the recommendations, implementation strategies and tools recommended by WHO. We also stress the need for action to increase the pace with which these recommendations are implemented in facilities across India.

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“…[40,41] Recent reports suggest than hand rubs other than alcohol can also be effective in eliminating microorganisms. [42] More data are required before conclusions can be drawn.…”

Section: Products For Hand Hygienementioning

confidence: 99%

Prevention and control of health care-associated infections through improved hand hygiene

Mathai

Allegranzi

Kilpatrick

et al. 2010

Indian Journal of Medical Microbiology

View full text Add to dashboard Cite

show abstract

“…This product had immediate antibacterial effect, explained by the rapid desorption of chlorhexidine from the nanocapsule wall, subsequent diffusion within bacteria, and sustained antibacterial effect. This immediate effect was a consequence of the slow release of chlorhexidine from the nanocapsule core against further bacterial colonization (Nhung et al, 2007).…”

Section: Antifungals Antibiotics and Antiparasiticsmentioning

confidence: 99%

Polymeric Nanocapsules for Drug Delivery

Guterres¹,

Poletto²,

Colom√©³

et al. 2010

Surfactant Science

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“…The immediate and sustained antibacterial effect was explained by an efficient chlorhexidine carrier system which improved the drug targeting to bacteria. 407 The clinical significance of these findings deserves further research. New compounds with good in vitro activity must be tested in vivo to determine their abilities to reduce transient and resident skin flora on the hands of caregivers.…”

Section: Other Agentsmentioning

confidence: 95%