Sustained antimicrobial activity and reduced toxicity of oxidative biocides through biodegradable microparticles

Sofokleous, Panagiotis; Ali, Shanom; Wilson, Peter; Buanz, Asma; Gaisford, Simon; Mistry, Dharmit; Fellows, Adrian; Day, Richard M.

doi:10.1016/j.actbio.2017.10.001

Cited by 13 publications

(9 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…These pH-sensitive liposome carriers allow for higher affinity to sites of infection, and subsequent release of contents. Microparticles have also shown the ability to perform similar actions, such as Sofokleous et al, who looked at the release of oxidative biocides from PLGA microparticles, which showed prolonged release and activity when introduced subcutaneously in Sprague Dawley rats [110].…”

Section: Nanoparticles As Carriers Of Antimicrobial Agents-nanoparticmentioning

confidence: 99%

Implantable antimicrobial biomaterials for local drug delivery in bone infection models

2019

View full text Add to dashboard Cite

Increased use of implantable biomedical devices demonstrates their potential in treating a wide variety of ailments and disorders in bone trauma and orthopaedic, reconstructive, and craniofacial applications. However, the number of cases involving implant failure or malfunction due to bacterial infection have also increased in recent years. Implanted devices can facilitate the growth of bacteria as these microorganisms have the potential to adhere to the implant and grow and develop to form biofilms. In an effort to better understand and mitigate these occurrences, biomaterials containing antimicrobial agents that can be released or presented within the local microenvironment have become an important area of research. In this review, we discuss critical factors that regulate antimicrobial therapy to sites of bone infection, such as key biomolecular considerations and platforms for delivery, as well as current in vivo models and current advances in the field.

show abstract

Section: Nanoparticles As Carriers Of Antimicrobial Agents-nanoparticmentioning

confidence: 99%

Implantable antimicrobial biomaterials for local drug delivery in bone infection models

2019

View full text Add to dashboard Cite

show abstract

“…Plasma generated H2O2 reacts with the acetyl donors of TAED and PAG to produce peracetic acid (PAA) which acts in synergy with H2O2 and other plasma generated RONS, providing a potent broad-spectrum antimicrobial solution (Figure 1). PAA at the low concentration used in this study, has been shown to be non-toxic in an animal model 15 . Further, PAA does not easily give rise to AMR 15 and is used in many industrial applications including food decontamination 17 , wastewater treatment 18 , hospital waste sterilisation 19 and medical instrument disinfection 20 .…”

mentioning

confidence: 78%

“…PAA at the low concentration used in this study, has been shown to be non-toxic in an animal model 15 . Further, PAA does not easily give rise to AMR 15 and is used in many industrial applications including food decontamination 17 , wastewater treatment 18 , hospital waste sterilisation 19 and medical instrument disinfection 20 . An advantage of PAA for these applications is that it does not leave harmful residues as it quickly decomposes to acetic acid, oxygen and water.…”

mentioning

confidence: 78%

“…To mitigate this likely problem, we investigated the use of two antimicrobial precursor acetyl donors, tetraacetylethlynediamine (TAED) and pentaacetate glucose (PAG), to amplify the antimicrobial effects of cold plasma. TAED and PAG and their by-products are readily biodegradable and are non-toxic if used at low concentrations and can be manufactured using green chemistry [14][15][16] . Plasma generated H2O2 reacts with the acetyl donors of TAED and PAG to produce peracetic acid (PAA) which acts in synergy with H2O2 and other plasma generated RONS, providing a potent broad-spectrum antimicrobial solution (Figure 1).…”

mentioning

confidence: 99%

See 1 more Smart Citation

On-demand cold plasma activation of acetyl donors for bacteria and virus decontamination

Szili

Ghimire²,

Patenall

et al. 2021

Applied Physics Letters

Self Cite

View full text Add to dashboard Cite

Antibiotics are commonly used as the first line of defense in the treatment of infectious diseases. However, the rise of antimicrobial resistance (AMR) is rendering many antibiotics less effective. Consequently, effective non-antibiotic antimicrobial strategies are urgently needed to combat AMR. This paper presents a strategy utilizing cold plasma for the "on-demand" activation of acetyl donor molecules. The process generates an aqueous-based antimicrobial formulation comprising a rich mixture of highly oxidizing molecules: peracetic acid, hydrogen peroxide and other reactive oxygen and nitrogen species. The synergistic potent oxidative action between these molecules is shown to be highly effective at eradicating common wound pathogenic bacteria (Pseudomonas aeruginosa and Staphylococcus aureus) and at inactivating a virus (SARS-CoV-2).Antimicrobials are the most widely used therapeutic drugs worldwide. They have revolutionised medicine, farming and agriculture, and veterinary care, and are used in many other industries including commercial paint formulations. However, their overuse, particularly in the case of antibiotics, has rendered them less effective through the rise of antimicrobial resistance (AMR) 1 . By 2050, AMR is forecasted to cause 10M deaths per annum resulting in a potential US$100 trillion shock to the global economy 2 . Consequently, there is a need for "on demand" antibiotic-free solutions for microbial eradication to eliminate the growing problem of AMR in healthcare and in our environment.

show abstract

“…1]. 18 Also, Fig. 1 shows the acetyl donor groups CH 3 CO on TAED and on the by-product AA of the TAED-H 2 O 2 reaction.…”

Section: Introductionmentioning

confidence: 99%

Cold Plasma Generation of Peracetic Acid for Antimicrobial Applications

et al. 2021

Self Cite

View full text Add to dashboard Cite

This study compares how a helium plasma jet activates peracetic acid (PAA) from tetraacetylethylenediamine (TAED) and acetic acid (AA). Hydrogen peroxide (H 2 O 2 ) generated from the plasma jets reacts with TAED resulting in the formation of PAA which further dissociates into AA. The by-product AA can also react with H 2 O 2 to form PAA, which might also be useful for antimicrobial applications when coupled with plasma. Equivalent concentrations of TAED and AA solutions are used to compare the formation of PAA after activation with a helium plasma jet. Our results showed that the concentrations of both H 2 O 2 and PAA in plasma-activated TAED (PAT) are higher than plasma-activated AA (PAAA), and that PAT is more efficient in reducing the growth of Pseudomonas aeruginosa and Staphylococcus aureus; the pathogens commonly found in wounds. The results are attributed to the presence of more acetyl donor groups in TAED, resulting in the formation of higher concentrations of PAA and H 2 O 2 .

show abstract

Sustained antimicrobial activity and reduced toxicity of oxidative biocides through biodegradable microparticles

Abstract: Graphical abstract

Cited by 13 publications

References 32 publications

Implantable antimicrobial biomaterials for local drug delivery in bone infection models

Implantable antimicrobial biomaterials for local drug delivery in bone infection models

On-demand cold plasma activation of acetyl donors for bacteria and virus decontamination

Cold Plasma Generation of Peracetic Acid for Antimicrobial Applications

Contact Info

Product

Resources

About