Sustained Arc/Arg3.1 Synthesis Controls Long-Term Potentiation Consolidation through Regulation of Local Actin Polymerization in the Dentate Gyrus<i>In Vivo</i>

Messaoudi, Elhoucine; Kanhema, Tambudzai; Soulé, Jonathan; Tiron, Adrian; Dagytė, Girstautė; Silva, Bruno da; Bramham, Clive R.

doi:10.1523/jneurosci.2883-07.2007

Cited by 418 publications

(493 citation statements)

References 75 publications

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“…For example, the activity-regulated cytoskeletal-associated protein (Arc/Arg3.1), whose expression is known to be dependent on Akt-mammalian target of rapamycin activation, was found to regulate a-amino-3-hydroxy-5-methyllisoxazole-4-propionic acid receptor trafficking (103) . In agreement with this, the expression of Arc/Arg3.1 was shown to facilitate changes in synaptic strength and the induction of morphological changes, such as those dependent on actin-polymerisation (140,141) (Fig. 2(B)).…”

Section: Molecular Basis Of Memorysupporting

confidence: 70%

Flavonoids as modulators of memory and learning: molecular interactions resulting in behavioural effects

Rendeiro

Guerreiro

et al. 2012

Proc. Nutr. Soc.

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There is considerable interest in the potential of a group of dietary-derived phytochemicals known as flavonoids in modulating neuronal function and thereby influencing memory, learning and cognitive function. The present review begins by detailing the molecular events that underlie the acquisition and consolidation of new memories in the brain in order to provide a critical background to understanding the impact of flavonoid-rich diets or pure flavonoids on memory. Data suggests that despite limited brain bioavailability, dietary supplementation with flavonoid-rich foods, such as blueberry, green tea and Ginkgo biloba lead to significant reversals of age-related deficits on spatial memory and learning. Furthermore, animal and cellular studies suggest that the mechanisms underpinning their ability to induce improvements in memory are linked to the potential of absorbed flavonoids and their metabolites to interact with and modulate critical signalling pathways, transcription factors and gene and/or protein expression which control memory and learning processes in the hippocampus; the brain structure where spatial learning occurs. Overall, current evidence suggests that human translation of these animal investigations are warranted, as are further studies, to better understand the precise cause-and-effect relationship between flavonoid intake and cognitive outputs. Flavonoids: Memory: Learning: HippocampusDiet is an important lifestyle factor, which in recent times has been investigated for its influence on cognitive function and the incidence and onset of neurodegenerative disorders (1,2) . It has long been known that a diet high in saturated fats negatively impacts on cognitive processing and increases the risk of neurological dysfunction in both animals and human subjects (3,4) , while energy restriction (reduction in approximately 30 % energy intake) protects the brain from injury (5,6) . Recently, significant evidence has emerged to indicate that phytochemical-rich foods, and in particular those rich in flavonoids, may reverse agerelated deficits in cognitive function in both animals and human subjects (7)(8)(9) . For example, the PAQUID prospective study examined cognitive performance in 1640 subjects (aged at least 65 years and cognitively normal at baseline) on four occasions over a 10-year-period and found that flavonoid-intake was associated with a significantly better cognitive performance over time (7) (P = 0 . 046). Furthermore, a cross-sectional study examining the relationship between the intake of three common flavonoid-containing foods (chocolate, wine and tea) and cognitive performance in elderly individuals revealed that there was a dose-dependent, positive relationship between the intake of these foods and performance on multiple cognitive outcomes (Kendrick Object Learning Test, Digit Symbol Test, Block Design, Mini-Mental State Examination and Controlled Oral Word Association Test) (10) . More recently, the consumption of dietary flavonoids, especially

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Section: Molecular Basis Of Memorysupporting

confidence: 70%

Flavonoids as modulators of memory and learning: molecular interactions resulting in behavioural effects

Rendeiro

Guerreiro

et al. 2012

Proc. Nutr. Soc.

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“…Messaoudi et al (11) reported that Arc protein synthesis was required for BDNF-induced LTP. Furthermore, two waves of Arc induction have been observed after a single spatial exploration (19).…”

Section: Discussionmentioning

confidence: 99%

“…Arc mRNA has been detected in cell bodies, dendrites, and spines after stimulation (7,8), and the Arc protein could be synthesized locally at dendritic spines (9,10). Arc is known to be required for the endocytosis of AMPA receptors (10) and for long-term potentiation (LTP)-induced F-actin stabilization (9,11). Okuno et al (12) reported that Arc plays a role in the inverse synaptic tagging of silent synapses; Arc accumulated in silent synapses to reduce surface AMPA receptors (12).…”

mentioning

confidence: 99%

Class I Histone Deacetylase-mediated Repression of the Proximal Promoter of the Activity-regulated Cytoskeleton-associated Protein Gene Regulates Its Response to Brain-derived Neurotrophic Factor

Nakashima

Tabuchi

Shimotori

et al. 2015

Journal of Biological Chemistry

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Background: Activity-regulated cytoskeleton-associated protein (Arc) transcription is activated by BDNF. Results: BDNF activated the Arc proximal promoter, whereas class I histone deacetylases (HDACs) inhibited this activation. Conclusion: Class I HDACs repress BDNF-induced Arc transcription through its serum response element-containing proximal promoter. Significance: Neuronal Arc expression is regulated by chromatin structure, which may lead to long-lasting changes in neuronal functions.

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“…Intrahippocampal infusion of BDNF resulted in the accumulation of Arc transcripts in dendrites and triggered long-term potentiation (BDNF-LTP) at medial perforant path-granule cell synapses in vivo (Messaoudi et al, 2007;Ying et al, 2002), and similar effects were observed in cultured cerebrocortical neurons (Rao et al, 2006), but the mechanisms involved have not been clarified. BDNF signaling induces the phosphorylation of ZBP1 and local synthesis of b-actin in growth cones, contributing to growth cone turning (Sasaki et al, 2010).…”

Section: Cis-acting Elements and Mrna Transport Into Dendritesmentioning

confidence: 99%

BDNF-induced local protein synthesis and synaptic plasticity

2014

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a b s t r a c tBrain-derived neurotrophic factor (BDNF) is an important regulator of synaptic transmission and longterm potentiation (LTP) in the hippocampus and in other brain regions, playing a role in the formation of certain forms of memory. The effects of BDNF in LTP are mediated by TrkB (tropomyosin-related kinase B) receptors, which are known to be coupled to the activation of the Ras/ERK, phosphatidylinositol 3-kinase/Akt and phospholipase C-g (PLC-g) pathways. The role of BDNF in LTP is best studied in the hippocampus, where the neurotrophin acts at pre-and post-synaptic levels. Recent studies have shown that BDNF regulates the transport of mRNAs along dendrites and their translation at the synapse, by modulating the initiation and elongation phases of protein synthesis, and by acting on specific miRNAs. Furthermore, the effect of BDNF on transcription regulation may further contribute to long-term changes in the synaptic proteome. In this review we discuss the recent progress in understanding the mechanisms contributing to the short-and long-term regulation of the synaptic proteome by BDNF, and the role in synaptic plasticity, which is likely to influence learning and memory formation.This article is part of the Special Issue entitled 'BDNF Regulation of Synaptic Structure, Function, and Plasticity'.

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Sustained Arc/Arg3.1 Synthesis Controls Long-Term Potentiation Consolidation through Regulation of Local Actin Polymerization in the Dentate GyrusIn Vivo

Cited by 418 publications

References 75 publications

Flavonoids as modulators of memory and learning: molecular interactions resulting in behavioural effects

Flavonoids as modulators of memory and learning: molecular interactions resulting in behavioural effects

Class I Histone Deacetylase-mediated Repression of the Proximal Promoter of the Activity-regulated Cytoskeleton-associated Protein Gene Regulates Its Response to Brain-derived Neurotrophic Factor

BDNF-induced local protein synthesis and synaptic plasticity

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