Sustained Attention and Interference Control Among 7-Year-Old Children With a Familial High Risk of Schizophrenia or Bipolar Disorder—A Nationwide Observational Cohort Study

Burton, Birgitte Klee; Vangkilde, Signe; Petersen, Anders; Skovgaard, L. T.; Jepsen, Jens Richardt Møllegaard; Hemager, Nicoline; Christiani, Camilla Jerlang; Spang, Katrine Soeborg; Ellersgaard, Ditte; Greve, Aja; Gantriis, Ditte Lou; Eichele, Heike; Mors, Ole; Nordentoft, Merete; Thorup, Anne; Plessen, Kerstin Jessica

doi:10.1016/j.bpsc.2018.04.012

Cited by 23 publications

(32 citation statements)

References 48 publications

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“…Our teacher-report measures confirmed that neuropsychiatric impairments were present in multiple settings, indicating pervasiveness. Our findings of broad ranging impairments is consistent with studies of common polygenic risk 37 and familial risk 38,39 of psychiatric disorder, that find that genetic risk is associated with disrupted childhood neurodevelopment across several domains. Psychiatric disorder was present in control siblings at rates in line with previous population studies that have used the same instruments as in the current study 40,41 as well as with previous studies that have compared ND-CNV carriers to controls 42,43 .…”

Section: Discussionsupporting

confidence: 90%

Genotype–phenotype associations in children with copy number variants associated with high neuropsychiatric risk in the UK (IMAGINE-ID): a case-control cohort study

Chawner

Owen

Holmans

et al. 2019

The Lancet Psychiatry

104

125

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Background: A variety of Copy Number Variants are associated with a high risk of neurodevelopmental and psychiatric disorders (ND-CNVs). We aimed to characterise the impact of ND-CNVs on childhood development and investigate whether different ND-CNVs lead to distinct and specific patterns of cognitive and behavioural outcomes. Methods: 258 children with ND-CNVs (13 CNVs across 9 loci) were systematically assessed for psychiatric disorders as well as broader traits of neurodevelopmental, cognitive and psychopathological origin. A comparison was made with 106 control siblings, in order to test the hypothesis that phenotypes would differ by genotype, both quantitatively, in terms of severity, and qualitatively in the pattern of associated impairments. Outcomes: 79.8% of ND-CNVs carriers met criteria for one or more psychiatric disorders (OR=13.8 compared to controls): the risk of ADHD (OR=6.9), ODD (OR=3.6), anxiety disorders (OR=2.9), and ASD traits (OR=44.1) was particularly high. ND-CNVs carriers were impaired across all neurodevelopmental, cognitive, and psychopathological traits relative to controls. Only moderate quantitative and qualitative differences in phenotypic profile were found between genotypes. In general, the range of phenotypes was broadly similar for all ND-CNV genotypes. Traits did show some evidence of genotypic specificity, however the specific genotype accounted for a low proportion of variance in outcome (5-20% depending on trait). Interpretation: The 13 ND-CNVs studied have a similar range of adverse effects on childhood neurodevelopment, despite subtle quantitative and qualitative differences. Our findings suggest that genomic risk for neuropsychiatric disorder has pleiotropic effects on multiple processes and neural circuits, and provides important implications for research into genotype-phenotype relationships within psychiatry.

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Section: Discussionsupporting

confidence: 90%

Genotype–phenotype associations in children with copy number variants associated with high neuropsychiatric risk in the UK (IMAGINE-ID): a case-control cohort study

Chawner

Owen

Holmans

et al. 2019

The Lancet Psychiatry

104

125

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“…Sustaining attention over prolonged periods of time is of great interest to cognitive psychologists. This is recognized by the fact that the sustained attention is critical for successful cognitive processing (Coull et al, 1996), and a number of psychiatric disorders, e.g., attention deficit hyperactivity disorder (Liu et al, 2015), schizophrenia (Burton et al, 2018), depression (Ye et al, 2018), etc., always show symptoms of deficits in sustained attention. The increasing number of evidences indicate that sustained attention could be dissociated into two attentional processes based on whether the attentional focus is external or internal (Chun et al, 2011; Fortenbaugh et al, 2017).…”

Section: Introductionmentioning

confidence: 99%

The Inter-Regional Connectivity Within the Default Mode Network During the Attentional Processes of Internal Focus and External Focus: An fMRI Study of Continuous Finger Force Feedback

et al. 2019

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Sustained attention involves two distinct processes, i.e., external focus and internal focus. Some recent neuroimaging studies employed the instruction of experimenters or the self-report from participants to generate the two attentional processes, and observed that the default mode network (DMN) was also responding to the external focus. These observations challenged the general view that the DMN accounts for the internally directed cognition, e.g., unfocused mind wandering, task independent-thoughts and internally focused events. Notably, the instruction or self-report may not effectively ensure the participants engage in the external focus/internal focus, and thus, the functional significance of the DMN for the externally focused process remains to be verified. In the present study, a new task paradigm, i.e., real/sham continuous feedback of finger force, was employed to generate the attentional process of external focus/internal focus, and the functional connectivity among the node regions of the DMN was further investigated in the two processes respectively. We found that two regions of the DMN, posterior cingulate cortex and left inferior parietal cortex/angular gyrus showed stronger inter-regional connectivity in the externally focused process than it in the internally focused process. Intriguingly, this functional connectivity was closely related to the behavioral performance in the process of external focus. These findings implicated that the functional significance of the DMN in sustained attention was more than responding to the internally directed cognition, and the task paradigm of continuous finger force feedback could benefit for the future studies on the externally focused/internally focused process of sustained attention.

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“…Moreover, in the premorbid phase the early signs of later schizophrenia (SZ) or bipolar disorder (BD) can present themselves already in childhood as e.g., anxiety, depression, or other non-psychotic disorders (5, 6). The first results from The Danish High Risk and Resilience Study—VIA 7 confirmed this by showing that already by age seven, children born to parents diagnosed with SZ and BD present much higher rates of a psychiatric diagnosis as well as cognitive deficits (only FHR SZ) across several domains, and motor problems (7–10). However, research is sparse when it comes to the question whether these abnormalities or developmental delays diminish over time, indicating that the individuals only suffer from those deficits and symptoms in a transitory manner and then catch up compared with the typically developing children, or whether the problems become even worse.…”

Section: Introductionmentioning

confidence: 89%

“…Especially anxiety, ADHD, and stress and adjustment disorders were more prevalent in both of the FHR-groups. Children with FHR for SMI also showed impairments in motor functioning (9) and in sustained attention and interference control (10). Further, children with FHR for both mental disorders were found to be at a greater risk of growing up under low socioeconomic status and reported more adverse life events than the controls based on interviews with the caregivers (unpublished data).…”

Section: Introductionmentioning

confidence: 99%

The Danish High Risk and Resilience Study—VIA 11: Study Protocol for the First Follow-Up of the VIA 7 Cohort −522 Children Born to Parents With Schizophrenia Spectrum Disorders or Bipolar Disorder and Controls Being Re-examined for the First Time at Age 11

et al. 2018

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Introduction: Offspring of parents with severe mental illness have an increased risk of developing mental illnesses themselves. Familial high risk cohorts give a unique opportunity for studying the development over time, both the illness that the individual is predisposed for and any other diagnoses. These studies can also increase our knowledge of etiology of severe mental illness and provide knowledge about the underlying mechanisms before illness develops. Interventions targeting this group are often proposed due to the potential possibility of prevention, but evidence about timing and content is lacking.Method: A large, representative cohort of 522 7-year old children born to parents with schizophrenia, bipolar disorder or controls was established based on Danish registers. A comprehensive baseline assessment including neurocognition, motor functioning, psychopathology, home environment, sociodemographic data, and genetic information was conducted from January 1, 2013 to January 31, 2016. This study is the first follow-up of the cohort, carried out when the children turn 11 years of age. By assessing the cohort at this age, we will evaluate the children twice before puberty. All instruments have been selected with a longitudinal perspective and most of them are identical to those used at inclusion into the study at age 7. A diagnostic interview, motor tests, and a large cognitive battery are conducted along with home visits and information from teachers. This time we examine the children's brains by magnetic resonance scans and electroencephalograms. Measures of physical activity and sleep are captured by a chip placed on the body, while we obtain biological assays by collecting blood samples from the children.Discussion: Findings from the VIA 7 study revealed large variations across domains between children born to parents with schizophrenia, bipolar and controls, respectively. This study will further determine whether the children at familial risk reveal delayed developmental courses, but catch up at age 11, or whether the discrepancies between the groups have grown even larger. We will compare subgroups within each of the familial high risk groups in order to investigate aspects of resilience. Data on brain structure and physical parameters will add a neurobiological dimension to the study.

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Sustained Attention and Interference Control Among 7-Year-Old Children With a Familial High Risk of Schizophrenia or Bipolar Disorder—A Nationwide Observational Cohort Study

Cited by 23 publications

References 48 publications

Genotype–phenotype associations in children with copy number variants associated with high neuropsychiatric risk in the UK (IMAGINE-ID): a case-control cohort study

Genotype–phenotype associations in children with copy number variants associated with high neuropsychiatric risk in the UK (IMAGINE-ID): a case-control cohort study

The Inter-Regional Connectivity Within the Default Mode Network During the Attentional Processes of Internal Focus and External Focus: An fMRI Study of Continuous Finger Force Feedback

The Danish High Risk and Resilience Study—VIA 11: Study Protocol for the First Follow-Up of the VIA 7 Cohort −522 Children Born to Parents With Schizophrenia Spectrum Disorders or Bipolar Disorder and Controls Being Re-examined for the First Time at Age 11

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