Sustained co-delivery of gemcitabine and cis-platinum via biodegradable thermo-sensitive hydrogel for synergistic combination therapy of pancreatic cancer

Shi, Kun; Xue, Bingxin; Jia, Yanpeng; Yuan, Liping; Han, Ruxia; Yang, Fan; Peng, Jinrong; Qian, Zhiyong

doi:10.1007/s12274-019-2342-7

Cited by 79 publications

(64 citation statements)

References 42 publications

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“…Biodegradable poly( d , l -lactide)-poly(ethylene glycol)-poly( d , l -lactide) (PLA-PEG-PLA) amphiphilic triblock copolymer showed the ability to self-assembly in aqueous medium into core-shell micelles, forming a physical network when exposed to the body temperature [76]. Injectable thermo-sensitive PLA–PEG–PLA for the local delivery of Gemcitabile (GEM) and Cisplatin (CisPt) was employed to promote synergistic combination therapy against pancreatic cancer [77]. Alternatively, poly( d , l -lactide) PLA was combined with pluronic L (PL) moieties in the preparation of three-block hydrogels (PLA–PL–PLA) proposed for intraperitoneal therapy of colon cancer [78,79].…”

Section: Synthetic Injectable Hydrogelsmentioning

confidence: 99%

Injectable Hydrogels for Cancer Therapy over the Last Decade

et al. 2019

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The interest in injectable hydrogels for cancer treatment has been significantly growing over the last decade, due to the availability of a wide range of starting polymer structures with tailored features and high chemical versatility. Many research groups are working on the development of highly engineered injectable delivery vehicle systems suitable for combined chemo-and radio-therapy, as well as thermal and photo-thermal ablation, with the aim of finding out effective solutions to overcome the current obstacles of conventional therapeutic protocols. Within this work, we have reviewed and discussed the most recent injectable hydrogel systems, focusing on the structure and properties of the starting polymers, which are mainly classified into natural or synthetic sources. Moreover, mapping the research landscape of the fabrication strategies, the main outcome of each system is discussed in light of possible clinical applications.

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Section: Synthetic Injectable Hydrogelsmentioning

confidence: 99%

Injectable Hydrogels for Cancer Therapy over the Last Decade

et al. 2019

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“…Gemcitabine and Cis-platinum were co-delivered using a biodegradable thermosensitive hydrogel system in the treatment of pancreatic cancer. Authors noted a strong synergistic effect of the drugs on the pancreatic cancer cell line Bxpc-3 with reduced side effects [28].…”

Section: Combination Of Dabrafenib and Trametinib Which Were Used Asmentioning

confidence: 99%

Curcumin, a Natural Golden Drug and Its Anticancer Aspects From Synthesis to Delivery: A Review

2020

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Cancer is a dreadful disease and, in most cases, leads to death even when it is being treated. Even though synthetic drugs are still in use for the treatment of cancer, the seriousness of the side effects of these drugs has boggled researcher’s mind to find more effective drugs which will help to overcome the side effects and have greater potency in trying to make the patient completely free of the disease. Recently, researchers turned their attention towards bio-components present in natural products. Curcumin, a polyphenol and the main constituent of a rhizome Curcuma longa, has geared significant interest due to its wide spectrum of therapeutics values, especially anticancer activity. Paper summarizes the chemistry and bio-metabolism of curcumin in the human body. Aim of this review article is to gather the dispersed efforts of researchers predominantly in improving the bioavailability of curcumin. In the present review, comprehensive literature on anticancer activity of Curcumin via combination therapy, structure modification, synthesis of analogues, novel delivery systems have been highlighted. Besides, the review paper explicated several challenges associated with Curcumin as an adjuvant chemotherapeutic agent and emphasizes more on clinical studies.

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“…[21,22] In our previous work, we have successfully synthesized a biodegradable and biocompatible thermosensitive hydrogel made of the amphiphilic triblock copolymer, poly(d,l-lactide)poly(ethylene glycol)-poly(d,l-lactide) (PDLLA-PEG-PDLLA, PLEL), with the ability to self-assemble into core-shell-like micelles in water under room temperature and to transfer into physically crosslinked non-flowing gel structure at physiological conditions. [23][24][25] Due to the hydrophilic characteristics in the nature of hydrogels, the amount and homogeneity of ERT loaded into this high water content structure may be limited. Hence, in our study, hollow mesoporous silica nanoparticles (HMSNs) were adopted to encapsulate ERT for increasing drug loading and improving the solubility to solve the incompatibility of hydrophobic agents in hydrogel systems (Scheme 1).…”

Section: Introductionmentioning

confidence: 99%

Injectable Thermosensitive Hydrogel Containing Erlotinib‐Loaded Hollow Mesoporous Silica Nanoparticles as a Localized Drug Delivery System for NSCLC Therapy

Zhou

Shi

et al. 2020

Advanced Science

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Erlotinib (ERT), oral administration agents, is one of the most pivotal targeted drugs in the treatment of non-small cell lung cancer (NSCLC); however, its poor solubility, low oral bioavailability, and capricious toxicity limit broader clinical applications. In this paper, a novel injectable matrix is prepared based on hollow mesoporous silica nanoparticles (HMSNs) and thermosensitive poly(d,l-lactide)-poly(ethylene glycol)-poly(d,l-lactide) (PDLLA-PEG-PDLLA, PLEL) hydrogel to encapsulate and localize the sustained release of ERT for improved efficacy against NSCLC. The test-tube-inversion method shows that this ERT-loaded hydrogel composite (ERT@HMSNs/gel) presents as an injectable flowing solution under room temperature and transfers into a physically crosslinked non-flowing gel structure at physiological temperature.The ERT@HMSNs/gel composite shows a much longer intratumoral and peritumoral drug retention by in vivo imaging study. Notably, this injectable drug delivery system (DDS) provides an impressive balance between antitumor efficacy and systemic safety in a mice xenograft model. The novel ERT loaded HMSNs/gel system may be a promising candidate for the in situ treatment of NSCLC. Moreover, this study provides a prospective platform for the design and fabrication of a nano-scaled delivery system for localized anticancer therapies.

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Sustained co-delivery of gemcitabine and cis-platinum via biodegradable thermo-sensitive hydrogel for synergistic combination therapy of pancreatic cancer

Cited by 79 publications

References 42 publications

Injectable Hydrogels for Cancer Therapy over the Last Decade

Injectable Hydrogels for Cancer Therapy over the Last Decade

Curcumin, a Natural Golden Drug and Its Anticancer Aspects From Synthesis to Delivery: A Review

Injectable Thermosensitive Hydrogel Containing Erlotinib‐Loaded Hollow Mesoporous Silica Nanoparticles as a Localized Drug Delivery System for NSCLC Therapy

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