Sustained Corticosterone Release in Lactating Rats following Olfactory Stimulation from the Pups1

Zarrow, M. X.; Schlein, P. A.; Denenberg, Victor H.; Cohen, Haim A.

doi:10.1210/endo-91-1-191

Cited by 56 publications

(19 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Rat pups trigger sustained corticosterone release in mothers (Zarrow, Schlein, Denenberg, & Cohen, 1972), the magnitude of which depends upon prior pup treatment (Smotherman, Wiener, Mendoza & Levine, 1977). The results of Experiment I confirm that maternal behavior modulates the pituitary-adrenal response of 2-day-old rat pups following early experience treatment.…”

Section: Experiments 11supporting

confidence: 56%

Mother‐infant interaction and the modulation of pituitary‐adrenal activity in rat pups after early stimulation

Smotherman

1983

Developmental Psychobiology

View full text Add to dashboard Cite

In Experiment I, handling or electric shock of 2-day-old rat pups triggered pituitary-adrenocortical activity. Interaction between mother and litter after pup treatment affected the magnitude and the time course of the pups' adrenocortical response. Mother-infant interactions following pup treatment on Day 2 were found to affect the responsiveness of pups to later stimulation. In Experiment II handled or shocked pups that were returned to a mother-absent nest were subsequently found to be less responsive to ACTH injection than were pups returned to a mother-present next following treatment. These data are discussed in terms of the reciprocity and synchrony in mother-infant interactions and the Maternal Mediation hypothesis of early experience.

show abstract

Section: Experiments 11supporting

confidence: 56%

Mother‐infant interaction and the modulation of pituitary‐adrenal activity in rat pups after early stimulation

Smotherman

1983

Developmental Psychobiology

View full text Add to dashboard Cite

show abstract

“…In addition, a study of the time-course of plasma corticosterone changes after ether [Zarrow et al, 1972] showed that this reduced response is not an artifact of the 15-min sampling procedure.…”

Section: Discussionmentioning

confidence: 99%

Pituitary-Adrenal Responsiveness during Lactation in Rats

1973

View full text Add to dashboard Cite

The pituitary-adrenal system plays an important role in the initiation and maintenance of lactation in rats, with the suckling stimulus itself inducing the release of ACTH. The recent finding of a reduced plasma corticosterone response to a variety of noxious stimuli during lactation led us to further investigate the activity of this system in lactating (L) rats, compared with post-parturient non-lactating ontrols (NL). Plasma and adrenal corticosterone and plasma ACTH were measured, the latter with a mouse bioassay. Over a 24 h period (12 L:12 D), basal concentrations of plasma corticosterone were elevated in L females, only at those times when the NL basal concentrations were at the trough in the diurnal cycle. At all times, the plasma corticosterone increase 15 min after ether was significantly lower (by a mean of 55 %) in L rats than in NL rats. The elevations in plasma corticosterone after ether were higher for all rats during the day. The night-day difference in response to ether was greater in L rats than in NL rats. Although morning basal levels were not significantly elevated in L females deprived of their litters for 24 h, in these females, as in continually lactating rats, stress concentrations of plasma ACTH (2–4 min after ether) were one third that of the NL controls. Finally, after dexamethasone treatment, the corticosterone output to exogenous ACTH was lower in the plasma and higher in the adrenal in L rats. Thus, pituitary-adrenal activity is altered in a variety of ways during lactation.

show abstract

“…Lactating rats are remarkably sensitive to the pup stimuli as reflected by their behavioral responsiveness (Bell et al 1974;Williams 1974, 1975;Wright et al 1977;Liu et al 1997) and pituitary-adrenal activity (Zarrow et al 1972;Smotherman et al 1976). For example, in response to brief, 15-min daily separations from the litter lactating dams increase maternal care behaviors, pup-licking and grooming, toward the pups in the rat (Liu et al 1997) and in mice (Priestnall 1973;D'Amato and Cabib 1987).…”

Section: Introductionmentioning

confidence: 99%

Periodic postpartum separation from the offspring results in long-lasting changes in anxiety-related behaviors and sensitivity to morphine in Long-Evans mother rats

2000

View full text Add to dashboard Cite

show abstract

Sustained Corticosterone Release in Lactating Rats following Olfactory Stimulation from the Pups1

Cited by 56 publications

References 0 publications

Mother‐infant interaction and the modulation of pituitary‐adrenal activity in rat pups after early stimulation

Mother‐infant interaction and the modulation of pituitary‐adrenal activity in rat pups after early stimulation

Pituitary-Adrenal Responsiveness during Lactation in Rats

Periodic postpartum separation from the offspring results in long-lasting changes in anxiety-related behaviors and sensitivity to morphine in Long-Evans mother rats

Contact Info

Product

Resources

About