2021
DOI: 10.1007/s00417-020-05037-4
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Sustained dasatinib treatment prevents early fibrotic changes following ocular trauma

Abstract: Purpose Posterior ocular trauma and the subsequent fibrotic retinal complication termed proliferative vitreoretinopathy (PVR) are leading causes of blindness in children and young adults. A previous study suggested that changes occurring within the first month post-trauma can lead to development of PVR later. The aim of this study was to examine the effect of dasatinib, a tyrosine kinase inhibitor clinically used to treat chronic myeloid leukemia, on fibrotic changes occurring within the first mo… Show more

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Cited by 2 publications
(2 citation statements)
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“…It is important to pay attention to the hazards of NPs, such as the potential toxicity of some NPs, which may be harmful to the retina. With the deepening of the research on NPs, the use of NPs is becoming more and more extensive, and NPs can also be used to treat proliferative vitreoretinopathy (PVR), retinal inflammation caused by autoimmune uveitis [150,151]. With the development of nanotechnology, many new fields have also been derived, such as biomimetic nanosponges [152].…”
Section: Challenges and Conclusionmentioning
confidence: 99%
“…It is important to pay attention to the hazards of NPs, such as the potential toxicity of some NPs, which may be harmful to the retina. With the deepening of the research on NPs, the use of NPs is becoming more and more extensive, and NPs can also be used to treat proliferative vitreoretinopathy (PVR), retinal inflammation caused by autoimmune uveitis [150,151]. With the development of nanotechnology, many new fields have also been derived, such as biomimetic nanosponges [152].…”
Section: Challenges and Conclusionmentioning
confidence: 99%
“…Quercetin also suppressed cigarette smoke extract-induced apoptosis and the expression of IL-1 β, IL-16, and IL-8, and upregulated Nrf2 in ARPE-19 cells [ 152 ], suggesting that quercetin inhibits oxidative stress-induced senescence. The senolytic drug dasatinib suppresses choroidal neovascularization, OIR, and retinal fibrosis [ 153 , 154 ]. Metformin, an AMPK activator, also has an anti-senescence effect [ 79 ].…”
Section: Senolytics Targeting Oxidative Stress-induced Cellular Senes...mentioning
confidence: 99%