Sustained Delivery of Methylsulfonylmethane from Biodegradable Scaffolds Enhances Efficient Bone Regeneration

Guo, Yunfei; Li, Pengpeng; Wang, Zongliang; Zhang, Peibiao; Wu, Xiaodong

doi:10.2147/ijn.s377036

Cited by 6 publications

(4 citation statements)

References 66 publications

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“…A novel study indicated that the incorporation of bioactive glass scaffolds and PLGA/ PLA polymers presents a promising bone repair in vitro [45]. Further studies also revealed that embedded agents such as antimicrobial agents, bone morphogenetic proteins [46], gelatin/nanohydroxyapatite cryogel [47], and methylsulfonylmethane [48] into PLGA/PLA polymers alleviate surgical complications, produce less pain, and prevent nonunion. So, the use of PLGA/PLA polymers makes it easy to load osteointegration molecules that could be released in a controlled manner (Ortega-Oller 2015).…”

Section: Polymersmentioning

confidence: 99%

Bone tissue engineering for osteointegration: Where are we now?

Aykora,

Uzun

2024

Polym. Bull.

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Bone fracture healing is a challenging process, due to insufficient and slow tissue repair. Sufferers from bone fractures struggle with one-third of nonunion, display graft rejection, high-costed implantation, or chronic pain. Novel advances in tissue engineering presented promising options for this strain. Biomaterials for bone repair allow accelerated regeneration, osteoblastic cell activation, and enhanced bone remodeling. There is a wide range of biomaterials that are biocompatible, bioresorbable, and biodegradable and used for bone tissue regeneration, promoting osteoconductive and osteoinductive properties. The main aim of bone tissue engineering is to generate rapid and optimal functional bone regeneration through a combination of biomaterials, growth factors, cells, and various agents. Recently bone tissue engineering has been attracted to the use of bioactive glass scaffolds incorporated with polymers and patient-specific fabrication of the bone healing material by 3D bioprinting. There are promising future outcomes that were reported by several research. The present review provides an outlook for recent most common biomaterials in bone tissue engineering suggesting bone tissue engineering practices should have been proceeded to clinical application.

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Section: Polymersmentioning

confidence: 99%

Bone tissue engineering for osteointegration: Where are we now?

Aykora,

Uzun

2024

Polym. Bull.

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“… 183 In conclusion, normal bone remodeling and bone homeostasis depend on the JAK1/STAT3/suppressor of cytokine signaling 3 (SOCS3) signaling pathway. 180 Moreover, the JAK2/STAT5B pathway is also fundamental for osteoblast formation, 184 as it acts on important transcription factors, such as T box transcription factor 3, RUNX2, and BMP‐7, 185 which further illustrates the role of JAKs and STATs in bone conversion under inflammatory conditions. JAK inhibition increases the expression of OCN and the Wnt signaling pathway (by stabilizing β‐catenin).…”

Section: Signaling Pathways and Molecules In Bone Homeostasismentioning

confidence: 99%

Regulation of bone homeostasis: signaling pathways and therapeutic targets

Wu,

Li,

Jiang

et al. 2024

MedComm

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As a highly dynamic tissue, bone is continuously rebuilt throughout life. Both bone formation by osteoblasts and bone resorption by osteoclasts constitute bone reconstruction homeostasis. The equilibrium of bone homeostasis is governed by many complicated signaling pathways that weave together to form an intricate network. These pathways coordinate the meticulous processes of bone formation and resorption, ensuring the structural integrity and dynamic vitality of the skeletal system. Dysregulation of the bone homeostatic regulatory signaling network contributes to the development and progression of many skeletal diseases. Significantly, imbalanced bone homeostasis further disrupts the signaling network and triggers a cascade reaction that exacerbates disease progression and engenders a deleterious cycle. Here, we summarize the influence of signaling pathways on bone homeostasis, elucidating the interplay and crosstalk among them. Additionally, we review the mechanisms underpinning bone homeostatic imbalances across diverse disease landscapes, highlighting current and prospective therapeutic targets and clinical drugs. We hope that this review will contribute to a holistic understanding of the signaling pathways and molecular mechanisms sustaining bone homeostasis, which are promising to contribute to further research on bone homeostasis and shed light on the development of targeted drugs.

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“…After stirring using a magnetic stirrer for 12 h, the blended HA/PLGA/chloroform mixture was poured onto a clean circular glass slide and slowly dried using a dryer at 50℃ to obtain HA/PLGA composite lm glass slides. (9)(10)(11) Characterization of the Cu/Gd@HA nanoparticles…”

Section: Samplementioning

confidence: 99%

“…(12)The contact angles of the Cu/Gd@HA/PLGA composites were measured using a picture contact angle instrument to assess their hydrophilicity or hydrophobicity. (9)The microstructure of the Cu/Gd@HA/PLGA composite scaffold was measured using micro-CT by using the companion software CTAn. T1-weighted MR images of the composites were obtained using a 3.0T MRI machine.…”

Section: Samplementioning

confidence: 99%

Cu/Gd co-doped hydroxyapatite/PLGA composites enhance MRI imaging and bone defect regeneration

Lu,

Xia,

et al. 2023

Preprint

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Background The hydroxyapatite (HA)/poly(lactide-co-glycolide) acid (PLGA) composite material is one of the most widely used orthopedic implant materials with good biocompatibility and plasticity. In recent years, cation doping has increased the number of its possible biological applications. Conventional HA/PLGA composite cannot be observed using X-rays after implantation in vivo and does not lead to good osteogenic induction results. Cu can regulate the proliferation and differentiation of osteoblasts, while Gd can effectively enhance the magnetic resonance imaging ability of materials.Methods In this study, a Cu/Gd@HA/PLGA composite was prepared to explore whether the introduction of Cu and Gd into a HA/PLGA composite could enhance the osteogenic ability of osteoblasts, the in vivo bone defect repair ability, and the magnetic resonance imaging (MRI) characteristics.Results The characterization of materials confirmed that the Cu/Gd@HA has HA morphology and crystal structure. The Cu/Gd@HA/PLGA composite material has excellent nuclear magnetic imaging ability, porosity and hydrophilicity, which can promote cell adhesion and implant detection.The results of in vitro experiments confirmed that the Cu/Gd@HA/PLGA composite enhanced the proliferation, differentiation, and adhesion ability of MC3T3-E1 cells and upregulated the expression of COL-1 and BMP-2 at the gene and protein levels. In vivo, the Cu/Gd@HA/PLGA composite still showed good T1-weighted MRI abilities and effectively enhanced the bone defect healing rate in rats.Conclusion These findings indicate that the Cu/Gd@HA/PLGA composites can effectively improve the T1-weighted magnetic resonance imaging ability of the materials, promote the proliferation and differentiation of osteoblasts in vitro, and increase the rate of bone defect healing in vivo.

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Sustained Delivery of Methylsulfonylmethane from Biodegradable Scaffolds Enhances Efficient Bone Regeneration

Cited by 6 publications

References 66 publications

Bone tissue engineering for osteointegration: Where are we now?

Bone tissue engineering for osteointegration: Where are we now?

Regulation of bone homeostasis: signaling pathways and therapeutic targets

Cu/Gd co-doped hydroxyapatite/PLGA composites enhance MRI imaging and bone defect regeneration

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