Sustained Dopamine Release Induced by Secretoneurin in the Striatum of the Rat: A Microdialysis Study

Agneter, Ernst; Sitte, Harald H.; Stöckl-Hiesleitner, S.; Fischer‐Colbrie, Reiner; Winkler, Hans; Singer, Ernst A.

doi:10.1046/j.1471-4159.1995.65020622.x

Cited by 67 publications

(25 citation statements)

References 17 publications

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“…SN superfusion on striatal slices induces dopamine release . A similar rise in dopamine release has been also reported in microdialysis studies in the rat striatum in vivo (Agneter et al, 1995). In addition, SN increases extracellular levels of several neurotransmitters, particularly excitatory amino acids monitored in the basal ganglia of the rat with in vivo microdialysis (You et al, 1996).…”

Section: Introductionsupporting

confidence: 76%

Early induction of secretoneurin expression following kainic acid administration at convulsant doses in the rat and gerbil hippocampus

2002

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The expression of secretogranin-II and its major proteolytic product secretoneurin (SN) is under the control of neuronal excitation, as demonstrated by treating rats with the excitotoxic kainic acid (KA). Differences in the structure and function of the hippocampus in rats and gerbils have been described; these suggest possible differential reactive responses to KA. In the present study, the SN immunostaining pattern in relation with cell damage is analyzed from 6 h to 4 days following KA administration in rats and gerbils. Dramatic differences in the expression of SN were found in the hippocampal complex following KA administration in gerbils and rats. A robust increase in SN immunoreactivity was detected in the pyramidal cell layer of the rat hippocampus, especially in the CA1 area. In the gerbil, however, a strong increase in SN immunostaining was detected in interneurons of the hippocampal formation, as shown by double-labeling immunohistochemistry to SN and the calcium-binding proteins parvalbumin, calbindin, and calretinin. In addition, no damage (in the hippocampal formation) or moderate damage (in the entorhinal cortex) was observed in the gerbil, in contrast to the rat. The administration of KA and the GABA-B receptor inhibitors (CGP56999A or CGP36742) to the gerbil resulted in a strong rise in SN immunoreactitivty in the CA1 pyramidal cell layer of the hippocampus, as in the rat. However, no increased cell damage was observed under these conditions. The present data provide evidence of a species-differential reactive response to KA that might be based, in part, on distinct inhibitory intrahippocampal circuitry.

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Section: Introductionsupporting

confidence: 76%

Early induction of secretoneurin expression following kainic acid administration at convulsant doses in the rat and gerbil hippocampus

2002

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“…SN specifically activates various cell functions including the migration of monocytes, eosinophils, fibroblasts, and smooth muscle cells, which suggests that the peptide may modulate inflammatory reactions (Wiedermann, 2000). In the central nervous system it may modulate neurotransmission since it stimulates DA release in the striatum (Agneter et al, 1995). Secretoneurin G-protein-linked receptors have been functionally characterized (Schneitler et al, 1998).…”

mentioning

confidence: 99%

Generation of the Melatonin Endocrine Message in Mammals: A Review of the Complex Regulation of Melatonin Synthesis by Norepinephrine, Peptides, and Other Pineal Transmitters

2003

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“…Preganglionic sympathetic neurons contain both substance P and SN, which suggests a role for SN in sympathetic nerves (Klimaschewski et al, 1995). Secretoneurin stimulates dopamine (DA) release in the rat striatum Agneter et al, 1995), stimulates neuritic growth in cerebellar granule cells in vitro (Gasser et al, 2003), and is neuroprotective in a murine model of stroke (Shyu et al, 2008). High concentrations of SN are found in human anterior and posterior pituitary (Schmid et al, 1995), several types of human endocrine tumors Taupenot et al, 2003), and also the rat hypothalamus (Marksteiner et al, 1993).…”

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confidence: 99%

Forebrain mapping of secretoneurin‐like immunoreactivity and its colocalization with isotocin in the preoptic nucleus and pituitary gland of goldfish

Canosa¹,

López²,

Scharrig³

et al. 2011

J of Comparative Neurology

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Secretoneurin, a 33-34 amino acid neuropeptide derived from the proteolytic processing of the secretogranin-II precursor protein, is reasonably well conserved in evolution. Goldfish secretoneurin shares >75% similarity overall with other vertebrate secretoneurin sequences. The secretoneurin peptide has numerous functions that include neuroinflammation, neurotransmitter release, and neuroendocrine regulation. A detailed description of the central distribution of secretoneurin immunoreactivity is only known for the rat. Using our polyclonal antibody against the central, conserved core of the secretoneurin peptide we studied the distribution of secretoneurin-like immunoreactivity in the goldfish brain. Secretoneurin immunoreactivity was found in the olfactory bulb, entopeduncular nucleus, preoptic nucleus, lateral part of the lateral tuberal nucleus, posterior periventricular nucleus, nucleus of the posterior recess, the nucleus of the saccus vasculosus, and nucleus isthmi. Secretoneurin-immunoreactive fibers were found in the dorsal part of the dorsal telencephalon, ventral and lateral parts of the ventral telencephalon, periventricular preoptic nucleus, pituitary, and the ventrocaudal aspect of the nucleus of the lateral recess. The most conspicuous secretoneurin immunoreactivity was found in the magnocellular and parvocellular cells of the preoptic nucleus that project to the pituitary. Double-labeling studies indicated coexpression with isotocin, the fish homolog of mammalian oxytocin. Clear colabeling for secretoneurin and isotocin in fibers terminating in the neurointermediate lobe suggests that secretoneurin maybe coreleased with isotocin. Previous work indicates that secretoneurin stimulates the release of luteinizing hormone from the goldfish anterior pituitary. Our findings further support a reproductive role for secretoneurin and related peptides, given the importance of oxytocin family peptides in reproductive behavior in vertebrates.

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Sustained Dopamine Release Induced by Secretoneurin in the Striatum of the Rat: A Microdialysis Study

Cited by 67 publications

References 17 publications

Early induction of secretoneurin expression following kainic acid administration at convulsant doses in the rat and gerbil hippocampus

Early induction of secretoneurin expression following kainic acid administration at convulsant doses in the rat and gerbil hippocampus

Generation of the Melatonin Endocrine Message in Mammals: A Review of the Complex Regulation of Melatonin Synthesis by Norepinephrine, Peptides, and Other Pineal Transmitters

Forebrain mapping of secretoneurin‐like immunoreactivity and its colocalization with isotocin in the preoptic nucleus and pituitary gland of goldfish

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