Sustained drug-delivery system: a promising therapy for denture stomatitis?

Neppelenbroek, Karin Hermana

doi:10.1590/1678-77572016ed003

Cited by 5 publications

(6 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Prescription of topical antifungal medicaments has been recommended to treat such infections [ 3 ]. However, in geriatric patients, the effectiveness of treatment is compromised by their limited motor skills, short term memory and special needs [ 4 , 5 ]. To address this issue, use of tissue conditioners as a drug delivery vehicle has been explored [ 4 ].…”

Section: Introductionmentioning

confidence: 99%

“…However, in geriatric patients, the effectiveness of treatment is compromised by their limited motor skills, short term memory and special needs [ 4 , 5 ]. To address this issue, use of tissue conditioners as a drug delivery vehicle has been explored [ 4 ]. Tissue conditioners allow direct, precise, and sustained availability of an antifungal medicament at the affected site without requiring patient compliance.…”

Section: Introductionmentioning

confidence: 99%

“…Tissue conditioners allow direct, precise, and sustained availability of an antifungal medicament at the affected site without requiring patient compliance. In addition, its resilient nature helps to absorb mechanical stresses generated during mastication and allow healing of traumatized tissues [ 4 ].…”

Section: Introductionmentioning

confidence: 99%

“…Literature shows that antifungal agents incorporated into tissue conditioners are effective for the prevention and treatment of denture stomatitis [ 1 , 4 ]. However, drug incorporation at commercially available concentration can alter mechanical and structural properties of the material such as increased hardness, loss of the cushioning effect and distortion [ 4 , 6 , 7 , 8 , 9 , 10 ]. In addition, there is risk of emergence of resistant microbial strains.…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Physico-Mechanical Properties of Commercially Available Tissue Conditioner Modified with Synthesized Chitosan Oligosaccharide

et al. 2022

View full text Add to dashboard Cite

This study aims to compare the hardness, sorption and solubility of commercially available tissue conditioner [TC] modified with chitosan [CS] and synthesized chitosan oligosaccharide [COS] in antifungal concentration. COS was synthesized by acid hydrolysis and characterized by FTIR and XRD. Experimental materials were formulated by incorporating each per gram of TC powder with effective antifungal concentration of chitosan 1.02 mg (Group 1: TC-CS) and 0.51 mg COS (Group 2: TC-COS). A commercially available TC was used as control (Group 0: CTC). Shore A hardness test was performed according to ASTM D 2240-05 (2010) standards on samples stored in dry environment, distilled water (DW) and artificial saliva (AS) at 37 °C (n = 5 per group). Percent weight changes (n = 5 per group) after storage in DW and AS was used to record sorption and solubility. One-way Anova with post hoc Tukey’s test was applied. FTIR and XRD confirmed low molecular weight and amorphous nature of COS. Experimental groups had higher Shore A hardness values; however, these changes were not significant. Greatest variations in durometer values (p ≤ 0.05) were observed during the first 24 h. Experimental groups had higher (p ≤ 0.05) percentage sorption and solubility. Samples stored in DW had significantly higher (p = 0.019) sorption, whereas material had higher (p = 0.005) solubility in AS. Mean solubility values in both immersion mediums was highest for Group 2, followed by group 1 and group 0. In addition, significant (p ≤ 0.05) increase in solubility upon aging was noted for each material. Experimental tissue conditioner had higher hardness, sorption and solubility. However, these changes are not substantial to interfere with their tissue healing property. Therefore, these materials may be considered and explored further as potential antimicrobial drug delivery agent for denture stomatitis patients.

show abstract

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Physico-Mechanical Properties of Commercially Available Tissue Conditioner Modified with Synthesized Chitosan Oligosaccharide

et al. 2022

View full text Add to dashboard Cite

show abstract

“…The main etiological factor for this disorder is poor denture hygiene. Additional etiological causes include denture plaque, bacterial and yeast contamination, continuous trauma from poorly fitting dentures, and continuous nighttime wear [ 8 ]. Patients with diabetes and those taking steroids orally or through inhalers are more vulnerable.…”

Section: Introductionmentioning

confidence: 99%

Influence of Five Different Commercially Available Mouthwashes on the Growth of Candida albicans Adhered to Customized Prefabricated Heat-Cured Denture Base Acrylic Resin Sheets: An In Vitro Study

Poyil,

Abdul Razak,

Mohamed Ali KP

et al. 2024

Cureus

View full text Add to dashboard Cite

Background The purpose of this in vitro investigation was to evaluate the impact of five distinct commercial mouthwashes on the development of Candida albicans that had been adhered to heat-cured acrylic resin sheets. Methods This in vitro investigation was carried out at the MES Medical College's Microbiology Department in Perinthalmanna, Kerala, India. A total of 72 heat-cured acrylic resin sheets, size 10 × 10 × 2 mm, were fabricated. After disinfection, all 72 acrylic sheets were placed in a flask containing a suspension of the standard strain of Candida species (American Type Culture Collection) and incubated at 37ºC for 24 hours. Then, the acrylic sheets were randomly divided into six groups, with each group containing 12 acrylic sheets. Group 1 was the control group to which no mouthwash was added. In group 2, Colgate Plax was added. In group 3, Hiora Himalaya was added. In group 4, Oral B was added. In group 5, Listerine was added. In group 6, Pepsodent was added. Colony-forming units (CFUs) were assessed using a colony counter every six, 24, 48, and 120 hours. After obtaining the pH and CFU of all 72 specimens, software known as the Statistical Package for Social Sciences (SPSS) (IBM Corp., Armonk, NY) was used to analyze the data. Results Candida albicans adhered to heat-cured denture base acrylic resin sheets differed significantly in response to commercially available mouthwashes (Oral B, Colgate Plax, and Pepsodent) and non-commercial mouthwashes (Hiora Himalaya and Listerine) that contained cetylpyridinium chloride. Conclusions Compared to other mouthwashes that do not contain cetylpyridinium chloride (Listerine and Hiora Himalaya), mouthwashes with cetylpyridinium chloride as the active ingredient (Oral B, Pepsodent, and Colgate Plax) have shown good antifungal properties against the adhering Candida albicans on denture base resin.

show abstract

Preparation and Evaluation of a Bio-Erodible Bio-Adhesive Drug Delivery System Designed for Intraoral Extended Release of Flurbiprofen: In Vitro and In Vivo Assessments

Penhasi

Reuveni²

2018

J Pharm Innov

View full text Add to dashboard Cite

Sustained drug-delivery system: a promising therapy for denture stomatitis?

Cited by 5 publications

References 24 publications

Physico-Mechanical Properties of Commercially Available Tissue Conditioner Modified with Synthesized Chitosan Oligosaccharide

Physico-Mechanical Properties of Commercially Available Tissue Conditioner Modified with Synthesized Chitosan Oligosaccharide

Influence of Five Different Commercially Available Mouthwashes on the Growth of Candida albicans Adhered to Customized Prefabricated Heat-Cured Denture Base Acrylic Resin Sheets: An In Vitro Study

Preparation and Evaluation of a Bio-Erodible Bio-Adhesive Drug Delivery System Designed for Intraoral Extended Release of Flurbiprofen: In Vitro and In Vivo Assessments

Contact Info

Product

Resources

About