Sustained intra-articular reactive oxygen species scavenging and alleviation of osteoarthritis by biocompatible amino-modified tantalum nanoparticles

Abstract

Recent studies highlight the vital role of oxidative stress and reactive oxygen species (ROS) during progression of osteoarthritis (OA). Attenuating oxidative stress and reducing reactive oxygen species generation in joints represent reasonable strategies for the treatment of osteoarthritis. To address the potential question for clinical translation, and improve the biocompatibility and long-term performance of current antioxidants, the present study provided high biocompatible small positively charged tantalum nanoparticles (Ta-NH2 NPs) with sustained intra-articular catalase activity and first applied to osteoarthritis intervention. Our in vitro results showed that Ta-NH2 NPs were stable with good biocompatibility, and protected viability and hyaline-like phenotype in H2O2-challenged chondrocytes. In addition, the in vivo biodistribution data demonstrated a sustained retention of Ta-NH2 NPs in the joint cavity, particularly in articular cartilage without organ toxicity and abnormality in hemogram or blood biochemistry indexes. Finally, compared with catalase (CAT), Ta-NH2 NPs exhibited long-term therapeutic effect in monosodium iodoacetate (MIA) induced osteoarthritis model. This study preliminarily explored the potential of simply modified metal nanoparticles as effective reactive oxygen species scavenging agent for osteoarthritis intervention, and offered a novel strategy to achieve sustained reactive oxygen species suppression using biocompatible Ta-based nano-medicine in oxidative stress related diseases.

One-step stromal vascular fraction therapy in osteoarthritis with tropoelastin-enhanced autologous stromal vascular fraction gel

“…Sagittal and coronal plane images from rat knee joint CT scans were utilized to evaluate the presence of osteophytes and signs of osteoporosis in OA. Furthermore, an analysis of bone volume to total volume (BV/TV) and trabecular thickness was conducted to further assess the bone health ( Jiang et al, 2023 ).…”

Carpal bone replacement using personalized 3D printed tantalum prosthesis

“…In this study, we performed lunate and scaphoid bone replacement with 3D printed tantalum, which we believed was the first attempt in the world. During the follow-ups, we found that patients had great improvement in grip strength and wrist movement after surgery, indicating that tantalum has good biocompatibility ( Jiang et al, 2023 ).…”

Tantalum Particles Promote M2 Macrophage Polarization and Regulate Local Bone Metabolism via Macrophage‐Derived Exosomes Influencing the Fates of BMSCs

“…In the study of metal implants such as Ti, [19,20] Ti particles can cause Mϕ M1 polarization and enhance osteoclast activity, thereby inducing bone resorption and accelerating the corrosion of the Ti itself. In the study of Ta particles on Mϕ polarization, existing literature suggests that Mϕ can polarize toward the M2 phenotype on surfaces of Ti-Ta composites with 20% Ta; [21] boronized Ta coatings reduce Mϕ inflammatory response and promote osteogenic matrix secretion in bone marrow-derived mesenchymal stem cells (BMSCs); [22] Ta nanoparticles scavenge reactive oxygen, suppress inflammatory factor secretion, [23,24] and increase the polarization of M2 Mϕ and decrease the Mϕ polarization to the M1 phenotype under the inflammatory microenvironment. [25] Thus, clarifying how Ta particles regulate Mϕ M2 polarization and the associated mechanisms is crucial for understanding their mediation effects in bone formation and resorption processes.…”