Sustained Mild Sleep Restriction Increases Blood Pressure in Women

Makarem, Nour; Zuraikat, Faris M.; Scaccia, Samantha; RoyChoudhury, Arindam; St‐Onge, Marie‐Pierre

doi:10.1161/hypertensionaha.120.16370

Cited by 2 publications

(3 citation statements)

References 6 publications

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“…Another study examined four blocks of sleep restricted to 4 hours/night for three nights, followed by 8 hours of recovery sleep for one night, and they found increased SBP during the first block of sleep restriction but not during subsequent blocks (22). More recent studies found that SBP increased after a week or more of mild sleep restriction (1.5 fewer hours/night) (18,19) and severe sleep restriction (4 hours/night) (20).…”

Section: Discussionmentioning

confidence: 99%

“…Sleep insufficiency is associated with elevated daytime HR and BP (7,(13)(14)(15). Studies of restricted sleep suggest that both degree and duration of sleep restriction contribute to elevation of HR and/ or BP (15)(16)(17)(18)(19)(20), with more nights of sleep restriction producing greater increases in daytime cardiac activity. Furthermore, elevated daytime cardiac activity due to sleep restriction may not return to baseline after full recovery sleep.…”

Section: Introductionmentioning

confidence: 99%

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Recovery Sleep After Sleep Restriction Is Insufficient to Return Elevated Daytime Heart Rate and Systolic Blood Pressure to Baseline Levels

Reichenberger¹,

Ness

Strayer

et al. 2023

Psychosom Med

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Objective: Sleep restriction alters daytime cardiac activity, including elevating heart rate (HR) and blood pressure (BP). There is minimal research on the cumulative effects of sleep loss and the response after subsequent recovery sleep on HR and BP. This study examined patterns of HR and BP across baseline, sleep restriction, and recovery conditions using multiple daytime cardiac measurements. Methods: Participants (15 healthy men, mean [standard deviation] = 22.3 [2.8] years) completed an 11-day inpatient protocol with three nights of 10 hours/night baseline sleep opportunity, five sleep restriction nights (5-hour/night sleep opportunity), and two recovery nights (10-hour/night sleep opportunity). Resting HR and BP were measured every 2 hours during wake. Multilevel models with random effects for individuals examined daytime HR and BP across study conditions and days into the study. Results: Mean daytime HR was 1.2 (0.5) beats/min lower during sleep restriction compared with baseline ( p < .001). During recovery, HR was 5.5 (1.0) beats/min higher ( p < .001), and systolic BP (SBP) was 2.9 (1.1) mm Hg higher ( p = .009). When accounting for days into the study (irrespective of condition) and measurement timing across the day, HR increased by 7.6 beats/min and SBP increased by 3.4 mm Hg across the study period ( p < .001). Conclusions: Our findings suggest that daytime HR and SBP increase after successive nights of sleep restriction, even after accounting for measurement time of day. HR and SBP did not recover to baseline levels after two recovery nights of sleep, suggesting that longer recovery sleep may be necessary to recover from multiple, consecutive nights of moderate sleep restriction.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Recovery Sleep After Sleep Restriction Is Insufficient to Return Elevated Daytime Heart Rate and Systolic Blood Pressure to Baseline Levels

Reichenberger¹,

Ness

Strayer

et al. 2023

Psychosom Med

View full text Add to dashboard Cite

show abstract

“…135 In an ecological model of sleep restriction, 6 weeks of maintaining a 1.5 hour reduction in sleep resulted in higher 24-hour systolic and mean arterial pressures compared to 6 weeks of maintained adequate sleep (at least 7 hours/night) with no difference in BP dipping. 136 Interestingly, in-office BP improved to a greater extent while maintaining adequate sleep compared to sleep restriction, indicating a potential benefit of stable sleep duration and timing on BP. Maintaining stable sleep patterns could mitigate the adverse effects of insufficient sleep on BP, 137,138 but no published clinical studies are available that support this hypothesis.…”

Section: Sleep and Bpmentioning

confidence: 97%

Toward Precision Medicine: Circadian Rhythm of Blood Pressure and Chronotherapy for Hypertension - 2021 NHLBI Workshop Report

et al. 2023

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Healthy individuals exhibit blood pressure variation over a 24-hour period with higher blood pressure during wakefulness and lower blood pressure during sleep. Loss or disruption of the blood pressure circadian rhythm has been linked to adverse health outcomes, for example, cardiovascular disease, dementia, and chronic kidney disease. However, the current diagnostic and therapeutic approaches lack sufficient attention to the circadian rhythmicity of blood pressure. Sleep patterns, hormone release, eating habits, digestion, body temperature, renal and cardiovascular function, and other important host functions as well as gut microbiota exhibit circadian rhythms, and influence circadian rhythms of blood pressure. Potential benefits of nonpharmacologic interventions such as meal timing, and pharmacologic chronotherapeutic interventions, such as the bedtime administration of antihypertensive medications, have recently been suggested in some studies. However, the mechanisms underlying circadian rhythm-mediated blood pressure regulation and the efficacy of chronotherapy in hypertension remain unclear. This review summarizes the results of the National Heart, Lung, and Blood Institute workshop convened on October 27 to 29, 2021 to assess knowledge gaps and research opportunities in the study of circadian rhythm of blood pressure and chronotherapy for hypertension.

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Sustained Mild Sleep Restriction Increases Blood Pressure in Women

Cited by 2 publications

References 6 publications

Recovery Sleep After Sleep Restriction Is Insufficient to Return Elevated Daytime Heart Rate and Systolic Blood Pressure to Baseline Levels

Recovery Sleep After Sleep Restriction Is Insufficient to Return Elevated Daytime Heart Rate and Systolic Blood Pressure to Baseline Levels

Toward Precision Medicine: Circadian Rhythm of Blood Pressure and Chronotherapy for Hypertension - 2021 NHLBI Workshop Report

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