Sustained motion perception deficit following optic neuritis

Abstract

Sustained motion perception deficit following ON may explain the continued visual complaints of patients long after recovery of visual acuity. Cortical activation patterns suggest that if plastic processes in higher visual regions contribute to the recovery of vision, this may be limited to static visual functions. Alternatively, cortical activation may reflect the visual percept (intact for visual acuity and impaired for motion perception), rather than demonstrating plastic processes. We suggest that motion perception should be included in the routine ophthalmologic tests following ON.

Temporal reorganization to overcome monocular demyelination

“…9 If prolonged VEP latencies of the FEs indicate clinically silent demyelination, then motion-perception deficits are expected in these eyes as well. In contrast, delayed latencies in FEs were not accompanied by impaired motion perception 8 and we found no correlation between the two. Moreover, when comparing a group of AEs and FEs with the same VEP latencies, impaired motion perception was evident only in the AEs (figure 1).…”

Optic Neuritis: From Magnocellular to Cognitive Residual Dysfunction

“…The present data are also consistent with previous findings showing impaired motion [19,30,31] or achromatic stimuli [20] processing, thus also suggesting a magnocellular deficit among ON patients that appeared to have full ophthalmologic recovery. Magnocellular deficits have been proposed to represent a behavioural correlate of demyelination in ON patients [31,32].…”

Dynamic Visual Tests to Identify and Quantify Visual Damage and Repair Following Demyelination in Optic Neuritis Patients

“…Importantly, object recognition is dependent on motion perception. Using the OFM protocol, we have demonstrated a sustained deficit in the affected eyes of ON patients, evident even 12 months following the optic neuritis attack, while standard visual functions had recovered 8 . Furthermore, impaired performance was associated with delayed conductions (delayed P100, reflecting demyelination) and improvement in motion perception was correlated with shortening of conduction rates (reflecting remyelination; linear least squares regression with calculation of the correlation coefficient F=27.3; p=0.0005; r=-0.87) 9 .…”