Sustained-release from nanocarriers: a review

Natarajan, Jayaganesh V.; Nugraha, Chandra; Ng, Xu Wen; Venkatraman, Subbu S.

doi:10.1016/j.jconrel.2014.05.029

Cited by 228 publications

(145 citation statements)

References 128 publications

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“…Despite a high 29 degree of anti-tumour activity, drug resistance and strong adverse effects limit its efficacy. To overcome this 30 problem several delivery strategies have been developed such as solid lipid nanoparticles and nanoliposomal 31 delivery systems, for example Doxil ® (Natarajan et al, 2014). Ion-exchange microspheres and, in particular, drug-eluting beads, have become the system of choice for drug delivery (Liu et al, 2001;Shuhendler et al, 2010).…”

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confidence: 99%

A calorimetric investigation of doxorubicin–polymer bead interactions

Waters

Swaine

Lewis

2015

International Journal of Pharmaceutics

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11Isothermal titration calorimetry (ITC) was utilised to investigate suitability of the technique to determine 12 the stoichiometry and thermodynamics of the interactions that occur between a commonly used chemotherapeutic 13 drug, namely doxorubicin, and a polymer bead-based drug delivery embolisation system (DC Bead™). Six 14 temperatures were selected for drug-polymer titrations (293 to 313 K) and in all cases an initially exothermic signal 15 reverted to an endothermic response upon the saturation of the beads with drug. From these experiments, and 16 subsequent calculations, the molar ratio of drug to SO 3 -(polymer) was found to be 0.4:1 at all temperatures studied. 17Enthalpic data was calculated from the raw ITC data with an average enthalpy of drug-polymer binding of -14.8 20in a small increase in the negativity in change in enthalpy recorded. The application of ITC in this study (with its 21 unique ability to monitor real-time interactions and facilitate stoichiometric calculations) resolves the lack of 22 knowledge regarding the thermodynamics of this specific drug-polymer interaction. This study confirms that ITC is 23 not only useful for this specific system, but also highlights the potential use of ITC for more general studies in this 24 area.

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mentioning

confidence: 99%

A calorimetric investigation of doxorubicin–polymer bead interactions

Waters

Swaine

Lewis

2015

International Journal of Pharmaceutics

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“…On the other hand, hydrophobic drug molecules can be encapsulated in NPs with relatively high drug-loading efficiency and excellent stability. 12,13 Despite the utilization of biocompatible and biodegradable materials, such as poly(lactic-co-glycolic acid) (PLGA), polylactic acid, and polycaprolactone, 14,15 nanocarriers are unavoidably met with quick excretion from the mononuclear phagocyte system. The hydrophilic polymer polyethylene glycol (PEG) can be decorated on the surface of NPs and then the NPs can be shielded by water molecules.…”

Section: Introductionmentioning

confidence: 99%

Gambogic acid-loaded biomimetic nanoparticles in colorectal cancer treatment

Zhang

Yang

et al. 2017

IJN

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Gambogic acid (GA) is expected to be a potential new antitumor drug, but its poor aqueous solubility and inevitable side effects limit its clinical application. Despite these inhe rent defects, various nanocarriers can be used to promote the solubility and tumor targeting of GA, improving antitumor efficiency. In addition, a cell membrane-coated nanoparticle platform that was reported recently, unites the customizability and flexibility of a synthetic copolymer, as well as the functionality and complexity of natural membrane, and is a new synthetic biomimetic nanocarrier with improved stability and biocompatibility. Here, we combined poly(lactic- co -glycolic acid) (PLGA) with red blood-cell membrane (RBCm), and evaluated whether GA-loaded RBCm nanoparticles can retain and improve the antitumor efficacy of GA with relatively lower toxicity in colorectal cancer treatment compared with free GA. We also confirmed the stability, biocompatibility, passive targeting, and few side effects of RBCm-GA/PLGA nanoparticles. We expect to provide a new drug carrier in the treatment of colorectal cancer, which has strong clinical application prospects. In addition, the potential antitumor drug GA and other similar drugs could achieve broader clinical applications via this biomimetic nanocarrier.

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“…Nos últimos anos a tecnologia de liberação controlada/modificada tem ganhado destaque, pois ela emergiu como uma importante alternativa capaz de resolver alguns dos problemas que acompanham o uso de substâncias ativas de interesse em alguns setores, 6 como por exemplo o agrícola (pesticidas e herbicidas), [7][8][9][10][11] alimentício, [12][13] o farmacêutico, [14][15][16][17] e, ineditamente, poderá ser aplicada para os cátions metálicos essenciais às plantas visando o aumento da eficiência dos fertilizantes, ou seja, aumento da disponibilidade destes no solo, minimização dos impactos ambientais e garantia de um desenvolvimento mundial considerado sustentável. Esta tecnologia propicia a liberação dos princípios ativos no decorrer de um determinado tempo através de processos físico-químicos, tais como dessorção e/ou erosão, sendo capaz de permitir a alteração das propriedades físico-químicas dos ativos para a liberação controlada/adequada destes, 6,18 possibilitando a atuação de forma contínua e prolongada dos cátions metálicos.…”

Section: Introductionunclassified

“…Um deles é o cálculo da taxa de encapsulamento dos nutrientes na matriz polimérica, como também a concentração de nutriente que este sistema libera no decorrer de um determinado tempo. [6][7][8][9][10][11][12][13][14][15][16][17][18] Assim, são requeridas técnicas analíticas para a quantificação da concentração dos cátions metálicos nesses processos.…”

Section: Introductionunclassified

Otimização multivariada de metodologia para digestão de micropartículas poliméricas carreadoras de cátions metálicos

et al. 2016

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Recebido em 28/03/2016, aceito em 06/07/2016, publicado na web em 16/08/2016 MULTIVARIATE OPTIMIZATION OF METHODOLOGY FOR POLYMERIC MICROPARTICLE DIGESTION METALLIC CATION CARRIERS. There are not reports in the literature of digestion processes of metallic cation carrier microparticles. Multivariate experimental designs were utilized to ensure an appropriate digestion for further analysis by atomic absorption spectroscopy. It was used a heater plate and the polimeric degradation was evaluated utilizing an analyzer of total organic carbon (TOC). For the total carbon (TC) content, the full factorial design 2 4 pointed the significance of sample volume (V Am ), in relation to the variables acid volume (V Ac ), temperature (T) and digestion time (t). However, according to the normal distribution graph it was noted a possible significance of the T and t effects. The same was observed for TOC, including the V Am × V Ac × T effect suggestive of complex behavior. In the central composite design all variables were again studied and the V AM was significant, promoting a TC decreasing at the lower evaluated level. By ANOVA a quadratic model without lack of fit was found, with the significant quadratic term. The best digestion condition was: 5.00 mL of sample, 10.00 mL of nitric acid, 60 ºC and 90 min. The multivariate optimization allowed an efficient digestion, with the initial carbon concentration of 4.60 mg L -1 decreased to 0.55 mg L -1 .Keywords: metallic cations; polymeric microparticles; sample preparation; digestion; multivariate experimental designs. INTRODUÇÃOOs cátions metálicos são parte essencial dos fertilizantes, pois eles são responsáveis por várias funções nas plantas, que vão desde a participação na síntese de proteínas, até sua presença em enzimas que participam de processos da fotossíntese. 1-2 Fertilizantes ou adubos são compostos químicos inorgânicos ou orgânicos utilizados para propiciar os nutrientes essenciais ao desenvolvimento das plantas, e são aplicados na agricultura para um maior rendimento da produção. 3 No entanto, atualmente, estudos 4-5 demonstram que para a maioria dos fertilizantes usados, parte dos seus nutrientes são perdidos no ambiente, podendo ocasionar uma série de contaminações ambientais. Por exemplo, os fertilizantes que possuem em sua composição nitratos e fosfatos podem perder parte desses compostos em processos de lixiviação, propiciando o processo de eutrofização em águas de mananciais e lençóis freáticos. Ainda, os fertilizantes quando não aplicados de forma correta podem proporcionar desequilíbrios no ecossistema e aumento do número das fontes de toxicidade aguda e carcinogênicas para os seres humanos. [4][5] Desta forma, o uso adequado dos fertilizantes é uma atividade que deve ser levada em consideração, visando à sustentabilidade econômica, ambiental e social do agronegócio mundial.Nos últimos anos a tecnologia de liberação controlada/modificada tem ganhado destaque, pois ela emergiu como uma importante alternativa capaz de resolver alguns dos problemas que acompanham ...

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Sustained-release from nanocarriers: a review

Cited by 228 publications

References 128 publications

A calorimetric investigation of doxorubicin–polymer bead interactions

A calorimetric investigation of doxorubicin–polymer bead interactions

Gambogic acid-loaded biomimetic nanoparticles in colorectal cancer treatment

Otimização multivariada de metodologia para digestão de micropartículas poliméricas carreadoras de cátions metálicos

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