Sustained-release hydrophilic matrix tablets of zileuton: formulation and in vitro/in vivo studies

High-amylose carboxymethyl starch matrices for oral sustained drug-release: In vitro and in vivo evaluation

“…There have been many attempts to simulate food affects in vitro -for example, surfactants have been added to the dissolution media (Qiu, Cheskin et al 1997;Dressman, Amidon et al 1998;Galia, Nicolaides et al 1998), dosage forms have been pre-soaked in peanut oil or placed in continuous oil contact to mimic the presence of a high fat meal (Mu, Tobyn et al 2003), or tested in different dissolution apparatuses under varied hydrodynamic, mixing conditions to examine the effects of mechanical destructive forces on drug-release from MR dosage forms (Shameem, Katori et al 1995). These methods are, however, only capable of imitating one or two aspects of physiological conditions.…”

Chronotherapeutics — A chronopharmaceutical approach to drug delivery in the treatment of asthma

“…Therefore, it is desirable to develop a sustained-release formulation in order to reduce the frequency of drug administration. Qiu et al [99] developed a sustained-release hydrophilic matrix tablet of zileuton and conducted in vitro/in vivo studies. Prolonged absorption of zileuton was achieved using the hydrophilic matrix system.…”

Sensitive and Validated Voltammetric Methods for Determination of Zileuton in Serum, Urine and Pharmaceutical Dosage Forms at Activated Glassy Carbon Electrode

“…Zileuton is a very slightly soluble compound without any ionizable functional group [8]. Recently, the molecule has been reported in the literature as a new efficient and safe antiacne drug [9].…”