Sustained Release of a Polymeric Wetting Agent from a Silicone-Hydrogel Contact Lens Material

Zheng, Ying; Dou, Jinbo; Wang, Yan; Li, Zhu; Yao, George C.; Kim, Young Hyun; Radke, Clayton J.; Wu, James Yuliang

doi:10.1021/acsomega.2c03310

Cited by 6 publications

(3 citation statements)

References 34 publications

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“…Research has also been conducted to slowly release a surface lubricant consisting of an amphiphilic polymer from silicone hydrogel contact lenses. This has the potential to be developed into a technology for administering bioactive biorelated molecules, such as proteins and nucleic acids, from contact lenses . We focus on the various potential applications of contact lenses.…”

Section: Conclusion and Future Perspectivementioning

confidence: 99%

“…This has the potential to be developed into a technology for administering bioactive biorelated molecules, such as proteins and nucleic acids, from contact lenses. 169 We focus on the various potential applications of contact lenses. Molecular recognition and control of chemical reactions are similar to the biological reaction mechanisms that the living body performs on the surface of the cell membrane.…”

Section: Conclusion and Future Perspectivementioning

confidence: 99%

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Biomimetic-Engineered Silicone Hydrogel Contact Lens Materials

Ishihara,

Shi,

Fukazawa

et al. 2023

ACS Appl. Bio Mater.

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Contact lenses are one of the most successful applications of biomaterials. The chemical structure of the polymers used in contact lenses plays an important role in determining the function of contact lenses. Different types of contact lenses have been developed based on the chemical structure of polymers. When designing contact lenses, materials scientists consider factors such as mechanical properties, processing properties, optical properties, histocompatibility, and antifouling properties, to ensure long-term wear with minimal discomfort. Advances in contact lens materials have addressed traditional issues such as oxygen permeability and biocompatibility, improving overall comfort, and duration of use. For example, silicone hydrogel contact lenses with high oxygen permeability were developed to extend the duration of use. In addition, controlling the surface properties of contact lenses in direct contact with the cornea tissue through surface polymer modification mimics the surface morphology of corneal tissue while maintaining the essential properties of the contact lens, a significant improvement for long-term use and reuse of contact lenses. This review presents the material science elements required for advanced contact lenses of the future and summarizes the chemical methods for achieving these goals.

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Section: Conclusion and Future Perspectivementioning

confidence: 99%

Section: Conclusion and Future Perspectivementioning

confidence: 99%

Biomimetic-Engineered Silicone Hydrogel Contact Lens Materials

Ishihara,

Shi,

Fukazawa

et al. 2023

ACS Appl. Bio Mater.

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“…Humectants have the capacity to establish a protective moisture film on the surface of dust suppression targets, reducing the rate of water evaporation from dust particles [15]. This, in turn, prolongs the effective duration of dust suppressants.…”

Section: Determination Of Humectantsmentioning

confidence: 99%

Research and Industrial Test of Anti-Freezing and Dust Suppression Agent for Truck Roads in Open-Pit Mines in Inner Mongolia, China

Zhao,

Du,

Bharti

et al. 2023

Processes

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To effectively resolve the inherent conflict between dust control and ice prevention on truck roads during North Surface Coal Mine winters, initially, via monomer preference experiments, the optimal monomers for wetting, moisturizing, and condensing functions were identified as sodium dodecylbenzene sulfonate (B), glycerol (N), and polyacrylamide (R). In parallel, through compound synergistic experiments, the constituent elements of an anti-freezing agent were determined, referred to as F. Subsequently, a four-factor three-level orthogonal test was conducted employing the monomers B, N, R, and the anti-freezing agent F. This evaluation focused on four principal control parameters: penetration rate, evaporation resistance, viscosity, and freezing point. The results led to the identification of the optimal antifreeze and dust suppressant formulation, designated as B2N3R1F3. Within the North Open-Pit Coal Mine, the self-developed dust suppressant was applied to the field test section. Multiple parameters were examined for 6 consecutive days, encompassing the water content of the pavement geotechnical soil, the concentrations of total dust and exhaled dust, and the particle size distribution of dust within this road section. The field test results show that: the average water content of the road surface within the dust suppressant test section measured at 12%; the dust reduction efficiency of total dust and exhaled dust is 93% and 91%; the proportion of dust particles with a size exceeding 500 μm increased by 54.6%. These comprehensive findings provide a empirical framework for the effective resolution of the practical challenge of simultaneously managing dust control and frost protection on truck roads within surface coal mines.

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