Sustained Release of Doxorubicin through Semi-Interpenetrating Polymer Network-Stabilized Micelles

Hwang, Juyoung; Jo, Min-Hee; Li, Chen; Park, Sun Joo; Kwak, Minseok

doi:10.1007/s13233-023-00191-0

Macromol. Res.

2023

DOI: 10.1007/s13233-023-00191-0

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Sustained Release of Doxorubicin through Semi-Interpenetrating Polymer Network-Stabilized Micelles

Juyoung Hwang,

Min-Hee Jo,

Chen Li

et al.

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Cited by 3 publications

References 41 publications

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Enhanced Drug Delivery with Oil‐in‐Water Nanoemulsions: Stability and Sustained Release of Doxorubicin

Hwang,

Park,

Kang

et al. 2024

Macromol. Rapid Commun.

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In this study, oil‐in‐water nanoemulsions are prepared, an isotropic mixture of oil, surfactant, and cosurfactants. The nanoemulsions exhibit stable structures and are capable of efficiently encapsulating hydrophobic drugs such as doxorubicin (Dox). Compared to polymeric micelles, nanoemulsions demonstrate enhanced stability and loading capacity for Dox. Furthermore, nanoemulsions release Dox steadily over 14 days, with 51.6% released within the initial 24 h and up to 80% over the subsequent period. These properties suggest that nanoemulsions can mitigate the side effects related to the burst release of Dox, thereby improving therapeutic efficacy and safety. Additionally, nanoemulsion‐treated cardiomyocytes show increased viability compared to those treated with free Dox, indicating the potential of nanoemulsions to alleviate Dox‐induced cardiotoxicity. Overall, nanoemulsions hold promise as versatile and efficient drug carriers for improving cancer treatment outcomes.

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Enhanced Drug Delivery with Oil‐in‐Water Nanoemulsions: Stability and Sustained Release of Doxorubicin

Hwang,

Park,

Kang

et al. 2024

Macromol. Rapid Commun.

View full text Add to dashboard Cite

show abstract

Preparation and Characterization of IPNs for Controlled Release of 5-Fluorouracil: Evaluation of Possible Use in Wound Dressing

Bayramoglu,

Yuksel,

Arica

2024

J Polym Environ

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Synthesis of acid-activated reversible conversion supramolecular nanoplatform: application in drug delivery and anti-tumor activity

Yang,

Chen,

Teng

et al. 2023

Macromol. Res.

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Sustained Release of Doxorubicin through Semi-Interpenetrating Polymer Network-Stabilized Micelles

Cited by 3 publications

References 41 publications

Enhanced Drug Delivery with Oil‐in‐Water Nanoemulsions: Stability and Sustained Release of Doxorubicin

Enhanced Drug Delivery with Oil‐in‐Water Nanoemulsions: Stability and Sustained Release of Doxorubicin

Preparation and Characterization of IPNs for Controlled Release of 5-Fluorouracil: Evaluation of Possible Use in Wound Dressing

Synthesis of acid-activated reversible conversion supramolecular nanoplatform: application in drug delivery and anti-tumor activity

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