Sustained release of insulin from sodium hyaluronate based dry powder formulations after pulmonary delivery to beagle dogs

Surendrakumar, K.; Martyn, G.P.; Hodgers, E.C.M.; Jansen, Mendel; Blair, J. A.

doi:10.1016/s0168-3659(03)00263-3

Cited by 145 publications

(75 citation statements)

References 19 publications

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“…Many particles presented a spherical or approximately spherical shape, although strongly convoluted, while some others displayed rather irregular morphology. The observed morphologies are similar to those reported for other spray-dried polysaccharide microparticles including matrixes of hyaluronic acid-hydroxypropyl cellulose [16] and chitosan-gelatin [17]. Nevertheless, spherical shapes have also been reported for many polysaccharide-based spray-dried microparticles [18][19][20], evidencing the important role of the matrix material in this regard.…”

Section: Association Of Drugs and Characterisation Of Microparticlessupporting

confidence: 84%

Inhalable Antitubercular Therapy Mediated by Locust Bean Gum Microparticles

et al. 2016

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Tuberculosis remains a major global health problem and alternative therapeutic approaches are needed. Considering the high prevalence of lung tuberculosis (80% of cases), the pulmonary delivery of antitubercular drugs in a carrier system capable of reaching the alveoli, being recognised and phagocytosed by alveolar macrophages (mycobacterium hosts), would be a significant improvement to current oral drug regimens. Locust bean gum (LBG) is a polysaccharide composed of galactose and mannose residues, which may favour specific recognition by macrophages and potentiate phagocytosis. LBG microparticles produced by spray-drying are reported herein for the first time, incorporating either isoniazid or rifabutin, first-line antitubercular drugs (association efficiencies >82%). Microparticles have adequate theoretical properties for deep lung delivery (aerodynamic diameters between 1.15 and 1.67 µm). The cytotoxic evaluation in lung epithelial cells (A549 cells) and macrophages (THP-1 cells) revealed a toxic effect from rifabutin-loaded microparticles at the highest concentrations, but we may consider that these were very high comparing with in vivo conditions. LBG microparticles further evidenced strong ability to be captured by macrophages (percentage of phagocytosis >94%). Overall, the obtained data indicated the potential of the proposed system for tuberculosis therapy.

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Section: Association Of Drugs and Characterisation Of Microparticlessupporting

confidence: 84%

Inhalable Antitubercular Therapy Mediated by Locust Bean Gum Microparticles

et al. 2016

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“…HA is a naturally occurring polymeric hydrogel based on a linear polysaccharide comprised of repeating units of Dglucuronic acid and N-acetyl-D-glucosamine, linked by ß-1, 4 and ß-1, three glycosidic bonds (8).…”

Section: Introductionmentioning

confidence: 99%

RETRACTED ARTICLE: The Influence of Sodium Hyaluronate, l-Leucine and Sodium Taurocholate on the Nebulization of Aqueous Betamethasone-17-Valerate Suspensions

Tadros

2008

AAPS PharmSciTech

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Abstract. The purpose of this research was to evaluate the variables that are suggested to influence the adsorption of the hydrophilic hyaluronic acid (HA) onto the surface of the hydrophobic betamethasone-17-valerate (BV) particles in order to formulate a nebulizable suspension. The adsorption of HA from aqueous solutions (0.04% to 0.16%, w/v) to a fixed BV concentration (0.04%, w/v) under different experimental conditions, was investigated. The method of preparation of HA-BV suspensions involved suspending BV particles either in the hydrated HA solution (method 1) or in water followed by addition of solid HA (method 2). Other variables like the time required for the adsorption to complete and temperature at which adsorption is carried out were studied. The nebulization of the suspensions was tested via an air jet nebulizer connected to a twin stage impinger. In order to improve the nebulization behavior of the optimized suspension, L-leucine or sodium taurocholate was incorporated in increasing concentrations (0.01-0.04%, w/v). The optimized suspension, having a nebulization efficiency of 33.75%, was achieved following the adsorption of HA (0.1%, w/v) onto BV particles adopting method 2 of preparation and extending for three days at 4°C. Incorporation of either l-leucine or sodium taurocholate significantly decreased the aggregate size of the optimized suspension and consequently caused significant increases in the nebulization efficiency to reach 46.87% and 56.25%, respectively.

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“…However, regulatory agencies and cost may limit the number of animals employed in these studies, which in turn may influence the statistical analysis of the results. The dog model has been utilized to study the delivery of insulin [65] or the treatment of some allergies [66]; monkeys and non-human primates have been employed to assess vaccine delivery [67] or drugs to treat cystic fibrosis [68], where sheep are considered a good model of lung injury [69].…”

Section: Animal Modelsmentioning

confidence: 99%