Sustained release of ketorolac tromethamine from poloxamer 407/cellulose nanofibrils graft nanocollagen based ophthalmic formulations

Orasugh, Jonathan Tersur; Dutta, Soumyadip; Das, Diphankar; Pal, Chandrika; Zaman, Aisha; Das, Sreyasi; Dutta, Koushik; Banerjee, Ritesh; Ghosh, Swapan K.; Chattopadhyay, Dipankar

doi:10.1016/j.ijbiomac.2019.08.143

Cited by 49 publications

(8 citation statements)

References 45 publications

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“…Ahmed A H Abdellatif et al., formulated cyclodextrin/adamantane-grafted polyethylene glycol-based self-assembling constructs for topical delivery of ketorolac tromethamine (Abdellatif et al., 2022 ). Yet another sustained and controlled systems of KT have been formulated into nanofibrils graft and polymer network hydrogels (Orasugh et al., 2019 ; Suhail et al., 2021 ). Priya Shahi et al., attempted to release KT chrono therapeutically by formulating microspheres and tablet in capsule system (Shahi et al., 2015 ).…”

Section: Introductionmentioning

confidence: 99%

Compression-coated pulsatile chronomodulated therapeutic system: QbD assisted optimization

Aldawsari

Naveen²,

Alhakamy

et al. 2022

Drug Delivery

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Pulsatile drug delivery systems have drawn attention in contemporary research for designing chronotherapeutic systems. The current work aims to design pulsatile ketorolac tromethamine tablets using compression coating for delayed delivery with a lag time suitable for the treatment of morning stiffness in arthritis. Rapidly disintegrating core tablets of ketorolac tromethamine were formulated using super-disintegrants, and the optimized formulation was compression using PEO WSR coagulant and Eudragit RLPO for delaying the release. The central composite design and response surface methodology were employed to optimize the formulation and process parameters namely PEO WSR Coagulant (X 1 ), Eudragit RLPO (X 2 ), and Hardness (X 3 ). The dependent variables optimized were lag time and time required for 95% drug release. Analysis using response surface graphs and mathematical modeling of the results allowed identifying and quantifying the formulation variables active on the selected responses. A polynomial equation fitted to the data was used to predict the composition with optimum responses. Compression-coated pulsatile tablets’ optimized composition exhibited a lag time of 9 h and released 95% of the ketorolac tromethamine in 17.42 h. Validation of the mathematical model assured the reliability of QBD in formulation design. In vivo X-ray imaging and pharmacokinetic studies established a strong relationship between the coated polymers maintaining the desired lag time for delayed delivery of the active to coincide with the chronobiology for enhanced bioavailability at the right time when needed.

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Section: Introductionmentioning

confidence: 99%

Compression-coated pulsatile chronomodulated therapeutic system: QbD assisted optimization

Aldawsari

Naveen²,

Alhakamy

et al. 2022

Drug Delivery

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“…Nanocellulose has been shown to play a variety of roles and offer several advantages in drug delivery applications, for example, for its release modulation, as a drug carrier, its improved mechanical properties, better compaction, and appropriate rheological modification [20,23,[149][150][151]. It has been shown that the addition of nanocellulose can control the release of incorporated drugs to significantly reduce consumption [152][153][154][155][156]. Nanofibers offer an additional advantage in terms of mechanical support and improvement of shelf life by improving oxidative stability [29].…”

Section: Marcus Johns and Emily Cranston (University Of British Colum...mentioning

confidence: 99%

“…Another local delivery route explored with nanocellulose is ocular drug delivery, which takes advantage of nanocellulose gel properties [153].…”

Section: Oral Deliverymentioning

confidence: 99%

Current international research into cellulose as a functional nanomaterial for advanced applications

et al. 2022

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This review paper provides a recent overview of current international research that is being conducted into the functional properties of cellulose as a nanomaterial. A particular emphasis is placed on fundamental and applied research that is being undertaken to generate applications, which are now becoming a real prospect given the developments in the field over the last 20 years. A short introduction covers the context of the work, and definitions of the different forms of cellulose nanomaterials (CNMs) that are most widely studied. We also address the terminology used for CNMs, suggesting a standard way to classify these materials. The reviews are separated out into theme areas, namely healthcare, water purification, biocomposites, and energy. Each section contains a short review of the field within the theme and summarizes recent work being undertaken by the groups represented. Topics that are covered include cellulose nanocrystals for directed growth of tissues, bacterial cellulose in healthcare, nanocellulose for drug delivery, nanocellulose for water purification, nanocellulose for thermoplastic composites, nanocellulose for structurally colored materials, transparent wood biocomposites, supercapacitors and batteries.

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“…The nano collagen scaffold decreased the PM critical gelation concentration and strengthened its gel formation, all while extending drug release compared to virgin PM gel. Thus, this nanocomposite combination is an ideal ophthalmic drug delivery method [103].…”

Section: Drug Deliverymentioning

confidence: 99%

Current Update of Collagen Nanomaterials—Fabrication, Characterisation and Its Applications: A Review

Fauzi

2021

Pharmaceutics

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Tissue engineering technology is a promising alternative approach for improvement in health management. Biomaterials play a major role, acting as a provisional bioscaffold for tissue repair and regeneration. Collagen a widely studied natural component largely present in the extracellular matrix (ECM) of the human body. It provides mechanical stability with suitable elasticity and strength to various tissues, including skin, bone, tendon, cornea and others. Even though exogenous collagen is commonly used in bioscaffolds, largely in the medical and pharmaceutical fields, nano collagen is a relatively new material involved in nanotechnology with a plethora of unexplored potential. Nano collagen is a form of collagen reduced to a nanoparticulate size, which has its advantages over the common three-dimensional (3D) collagen design, primarily due to its nano-size contributing to a higher surface area-to-volume ratio, aiding in withstanding large loads with minimal tension. It can be produced through different approaches including the electrospinning technique to produce nano collagen fibres resembling natural ECM. Nano collagen can be applied in various medical fields involving bioscaffold insertion or fillers for wound healing improvement; skin, bone, vascular grafting, nerve tissue and articular cartilage regeneration as well as aiding in drug delivery and incorporation for cosmetic purposes.

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Sustained release of ketorolac tromethamine from poloxamer 407/cellulose nanofibrils graft nanocollagen based ophthalmic formulations

Cited by 49 publications

References 45 publications

Compression-coated pulsatile chronomodulated therapeutic system: QbD assisted optimization

Compression-coated pulsatile chronomodulated therapeutic system: QbD assisted optimization

Current international research into cellulose as a functional nanomaterial for advanced applications

Current Update of Collagen Nanomaterials—Fabrication, Characterisation and Its Applications: A Review

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