Sustained release of levobupivacaine from temperature-sensitive injectable hydrogel for long-term local anesthesia in postoperative pain management

Zhang, Yujun; Shi, K.; Xi, Yang; Chen, Wen; Wang, Tianhong; Kang, Yi; Gong, Deying; Zhang, Qian; Zhang, Wensheng

doi:10.1016/j.biomaterials.2023.122129

Cited by 13 publications

(8 citation statements)

References 42 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The system could not only achieve rapid effect but also continuously release levobupivacaine for blocking nerves, significantly prolonging the local analgesic effect; it is an ideal choice for long-term postoperative pain treatment [45] Ropivacaine Hydrogels Sprague Dawley (SD) rat (subcutaneous injection)…”

Section: Postoperative Painmentioning

confidence: 99%

“…Therefore, a temperature-sensitive hydrogel system was studied, a liquid that could flow at room temperature and was transformed into semi-solid hydrogels once it entered the body. The hydrogel system not only lasted six times longer than ordinary levobupivacaine acid but also effectively relieved spontaneous pain in a rat model of sciatic nerve block, subcutaneous infiltration anesthesia, and postoperative pain ( Figure 3 ) [ 45 ]. Oh et al found that the hydrogel device not only significantly enhanced the release rate of local anesthetics such as ropivacaine but also extended the pain relief time of the drug to 24 h or more.…”

Section: Single Drug-based Nanoformulations For Pain Treatmentmentioning

confidence: 99%

“… Schematic illustration of hybrid levobupivacaine-loaded temperature-sensitive injectable hydrogel system used for the sustained release of anesthetics to achieve long-term local anesthesia in postoperative pain treatment [ 45 ]. Copyright 2023 Elsevier.…”

Section: Figurementioning

confidence: 99%

See 2 more Smart Citations

Nanomaterial-Based Drug Delivery Systems for Pain Treatment and Relief: From the Delivery of a Single Drug to Co-Delivery of Multiple Therapeutics

Xu,

Dong,

et al. 2023

Pharmaceutics

View full text Add to dashboard Cite

The use of nanomaterials in drug delivery systems for pain treatment is becoming increasingly common. This review aims to summarize how nanomaterial-based drug delivery systems can be used to effectively treat and relieve pain, whether via the delivery of a single drug or a combination of multiple therapeutics. By utilizing nanoformulations, the solubility of analgesics can be increased. Meanwhile, controlled drug release and targeted delivery can be realized. These not only improve the pharmacokinetics and biodistribution of analgesics but also lead to improved pain relief effects with fewer side effects. Additionally, combination therapy is frequently applied to anesthesia and analgesia. The co-encapsulation of multiple therapeutics into a single nanoformulation for drug co-delivery has garnered significant interest. Numerous approaches using nanoformulation-based combination therapy have been developed and evaluated for pain management. These methods offer prolonged analgesic effects and reduced administration frequency by harnessing the synergy and co-action of multiple targets. However, it is important to note that these nanomaterial-based pain treatment methods are still in the exploratory stage and require further research to be effectively translated into clinical practice.

show abstract

Section: Postoperative Painmentioning

confidence: 99%

Section: Single Drug-based Nanoformulations For Pain Treatmentmentioning

confidence: 99%

See 1 more Smart Citation

Nanomaterial-Based Drug Delivery Systems for Pain Treatment and Relief: From the Delivery of a Single Drug to Co-Delivery of Multiple Therapeutics

Xu,

Dong,

et al. 2023

Pharmaceutics

View full text Add to dashboard Cite

show abstract

“…To prolong the analgesic duration of traditional LAs, many slow-releasing LA formulations have been developed based on various types of materials including polymeric microspheres 7 - 9 , liposomes 10 , 11 , hydrogels 12 - 14 , peptides 15 and their hybrid systems 16 , 17 . Unfortunately, before the translation to clinical application, most formulations developed in laboratory are still facing many challenges including complicated preparation process, low drug-loading capacity and biocompatibility issue of the carrier materials.…”

Section: Introductionmentioning

confidence: 99%

Size control of ropivacaine nano/micro-particles by soft-coating with peptide nanosheets for long-acting analgesia

Liu,

Wu,

Peng

et al. 2024

Theranostics

Self Cite

View full text Add to dashboard Cite

Rationale: To meet the need of long-acting analgesia in postoperative pain management, slow-releasing formulations of local anesthetics (LAs) have been extensively investigated. However, challenges still remain in obtaining such formulations in a facile and cost-effective way, and a mechanism for controlling the release rate to achieve an optimal duration is still missing. Methods: In this study, nanosheets formed by a self-assembling peptide were used to encapsulate ropivacaine in a soft-coating manner. By adjusting the ratio between the peptide and ropivacaine, ropivacaine particles with different size were prepared. Releasing profile of particles with different size were studied in vitro and in vivo . The influence of particle size and ropivacaine concentration on effective duration and toxicity were evaluated in rat models. Results: Our results showed that drug release rate became slower as the particle size increased, with particles of medium size (2.96 ± 0.04 μm) exhibiting a moderate release rate and generating an optimal anesthetic duration. Based on this size, formulations at different ropivacaine concentrations generated anesthetic effect with different durations in rat sciatic nerve block model, with the 6% formulation generated anesthetic duration of over 35 h. Long-acting analgesia up to 48 h of this formulation was also confirmed in a rat total knee arthroplasty model. Conclusion: This study provided a facile strategy to prepare LA particles of different size and revealed the relationship between particle size, release rate and anesthetic duration, which provided both technical and theoretical supports for developing long-acting LA formulations with promising clinical application.

show abstract

“…[2][3][4][5][6] Recently, designing injectable in situ hydrogels with sustained drug release have become increasingly common innovations. [7][8][9][10] Hydrogels are a three-dimensional netted polymers composed of hydrophilic polymer chains that are formed by physical or chemical crosslinking methods. 11 Hydrogels have the benefits of a soft and wet surface and a high affinity for tissue, but are a weak irritant to the body.…”

Section: Introductionmentioning

confidence: 99%

Temperature-Sensitive Nanocarbon Hydrogel for Photothermal Therapy of Tumors

Tan,

Sijie,

et al. 2023

IJN

View full text Add to dashboard Cite

Background: Intelligent hydrogels continue to encounter formidable obstacles in the field of cancer treatment. A wide variety of hydrogel materials have been designed for diverse purposes, but materials with satisfactory therapeutic effects are still urgently needed. Methods: Here, we prepared an injectable hydrogel by means of physical crosslinking. Carbon nanoparticle suspension injection (CNSI), a sentinel lymph node imaging agent that has been widely used in the clinic, with sodium β-glycerophosphate (β-GP) were added to a temperature-sensitive chitosan (CS) hydrogel (CS/GP@CN) as an agent for photothermal therapy (PTT). After evaluating the rheological, morphological, and structural properties of the hydrogel, we used 4T1 mouse breast cancer cells and B16 melanoma cells to assess its in vitro properties. Then, we intratumorally injected the hydrogel into BALB/c tumor-bearing mice to assess the in vivo PTT effect, antitumor immune response and the number of lung metastases. Results: Surprisingly, this nanocarbon hydrogel called CS/GP@CN hydrogel not only had good biocompatibility and a great PTT effect under 808nm laser irradiation but also facilitated the maturation of dendritic cells to stimulate the antitumor immune response and had an extraordinary antimetastatic effect in the lungs. Discussion: Overall, this innovative temperature-sensitive nanocarbon hydrogel, which exists in a liquid state at room temperature and transforms to a gel at 37 °C, is an outstanding local delivery platform with tremendous PTT potential and broad clinical application prospects.

show abstract

Sustained release of levobupivacaine from temperature-sensitive injectable hydrogel for long-term local anesthesia in postoperative pain management

Cited by 13 publications

References 42 publications

Nanomaterial-Based Drug Delivery Systems for Pain Treatment and Relief: From the Delivery of a Single Drug to Co-Delivery of Multiple Therapeutics

Nanomaterial-Based Drug Delivery Systems for Pain Treatment and Relief: From the Delivery of a Single Drug to Co-Delivery of Multiple Therapeutics

Size control of ropivacaine nano/micro-particles by soft-coating with peptide nanosheets for long-acting analgesia

Temperature-Sensitive Nanocarbon Hydrogel for Photothermal Therapy of Tumors

Contact Info

Product

Resources

About