Sustained Release of Minocycline From Minocycline-Calcium-Dextran Sulfate Complex Microparticles for Periodontitis Treatment

Wu, Liangliang; Wu, Chen; Li, Feng; Morrow, Brian R; Garcı́a-Godoy, Franklin; Hong, Liang

doi:10.1016/j.xphs.2018.08.023

Cited by 24 publications

(22 citation statements)

References 42 publications

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“…The BUP-loaded nanocomplexes were prepared by admixing the polymeric solution and drug solution, and then dropwise adding the CaCl 2 solution to the mixture. 20,24 The detailed compositions of the complexes are presented in Tables 1 and 2. The anionic polymers (DS, CMC, and CMD) were dissolved in distilled water at concentration of 3-15% w/v.…”

Section: Methodsmentioning

confidence: 99%

“…In an earlier report, the electrostatic complex of DS and minocycline also exhibited a negative charge (−30 to −40 mV) independent of the ratio of the drug to polymer. 24 The drug content in dispersion was determined to be between 98% and 105%, with no degradation during the preparation process. This tendency has also been observed in CMD-and CMC-based complexes.…”

Section: Bulletin Of the Korean Chemical Societymentioning

confidence: 99%

“…Nanocomplex System of Bupivacaine for Sustained Release BULLETIN OF THE KOREAN CHEMICAL SOCIETY and the release profile from, the electrostatic complex. 24,37 The concentration of metal ions ranged from 0% to 1.0% w/v, as concentrations above 1.0% w/v, it was difficult to ensure isotonicity. Physicochemical properties of the DS-based nanocomplex with different ratios of drug to DS to Ca 2+ were characterized by particle size, homogeneity, zeta potential, and drug content (Table 2).…”

Section: Articlementioning

confidence: 99%

“…22,23 Yousefpour et al (2011) reported that the hydrophilic polymer formed electrostatic complexes with doxorubicin resulting in sustained release of the amine-containing cytotoxic agent. 17 Wu et al (2018) previously reported that metal ions could mediate the complex formation between DS and minocycline, further delaying drug release from the nanocomplex. 24 Thus, we assumed that electrostatic nanocomplex system of BUP with negatively charged biocompatible polymer can be an alternative for long-acting drug delivery, with simpler preparation process compared to liposomal system.…”

Section: Introductionmentioning

confidence: 98%

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Nanocomplex System of Bupivacaine with Dextran Sulfate for Parenteral Prolonged Delivery

Kim

Park

Kang

2020

Bulletin Korean Chem Soc

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An electrostatic complex system of bupivacaine (BUP), an amide-type analgesic agent, with an oppositely charged polymer was designed for parenteral sustained delivery. The complex was prepared by admixing the drug (0.25-1.0% w/v) with different anionic polymers (dextran sulfate, carboxymethylcellulose, or carboxymethyl dextran, 1.0-5.0% w/v), and then adding calcium ion (0-1.0% w/v) as the noncovalent crosslinking agent. Negatively charged complexes ranging from 10 to 2000 nm were formed after the positively charged BUP molecules amalgamated with the polymers after gentle agitation. Drug released from the complex was markedly sustained either by increasing the polymer to drug ratio, or by increasing the calcium ion content. The optimized nanocomplex consisted of the drug, dextran sulfate, and calcium ion at the ratio of 1:20:20 w/w/w, which supplied a sustained release profile over 7 days. Therefore, novel nanocomplex is expected to be an effective tool to provide a sustained release of the analgesic agent.

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Section: Methodsmentioning

confidence: 99%

Section: Bulletin Of the Korean Chemical Societymentioning

confidence: 99%

Section: Articlementioning

confidence: 99%

Section: Introductionmentioning

confidence: 98%

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Nanocomplex System of Bupivacaine with Dextran Sulfate for Parenteral Prolonged Delivery

Kim

Park

Kang

2020

Bulletin Korean Chem Soc

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“…Inspired from nature, a biomimetic delivery system was developed utilizing components of biological systems to improve the drug delivery performance [18,28,29]. In this study, we selected BSA as a stabilizer which could stabilize Cu(DDC) 2 MONs and minimize the number of large aggregations.…”

Section: Discussionmentioning

confidence: 99%

Biomimetic metal-organic nanoparticles prepared with a 3D-printed microfluidic device as a novel formulation for disulfiram-based therapy against breast cancer

Chang

Jiang

et al. 2020

Applied Materials Today

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Disulfiram (DSF) is currently tested in several clinical trials for cancer treatment in combination with copper (Cu) ions. Usually, DSF and Cu are administered in two separate formulations. In the body, DSF and Cu ions form diethyldithiocarbamate copper complex [Cu(DDC) 2 ] which has potent antitumor activities. However, the "two formulation" approach often achieved low Cu(DDC) 2 concentration at tumor regions and resulted in compromised anticancer efficacy. Therefore, preformed Cu(DDC) 2 complex administered in a single formulation will have better anticancer efficacy. However, the poor aqueous solubility of Cu(DDC) 2 is a significant challenge for its clinical use. In this work, a biomimetic nanoparticle formulation of Cu(DDC) 2 was produced with a novel SMILE (Stabilized Metal Ion Ligand complex) method developed in our laboratory to address the drug delivery challenges. The Metal-organic Nanoparticle (MON) is composed of Cu(DDC) 2 metal-organic complex core and surface decorated bovine serum albumin (BSA). Importantly, we designed a 3D-printed microfluidic device to further improve the fabrication of BSA/Cu(DDC) 2 MONs. This method could precisely control the MON preparation process and also has great potential for large scale production of Cu(DDC) 2 MON formulations. We also used a computational modeling approach to simulate the MON formation process in the microfluidic device. The optimized BSA/Cu(DDC) 2 MONs demonstrated good physicochemical properties. The MONs also showed potent antitumor activities in the breast cancer cell monolayers as well as the 3D-cultured tumor spheroids. The BSA/Cu(DDC) 2 MONs also effectively inhibited the growth of tumors in an orthotopic 4T1 breast tumor model. This current study provided a novel method to prepare a biomimetic MON formulation for DSF/Cu cancer therapy.

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Synthesis and Evaluation of Chitosan‐Heparin‐Minocycline Composite Membranes for Potential Antibacterial Applications

Xiao

Morrow

et al. 2020

Starch Stärke

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In this study, novel antibacterial composite membranes, namely Chitosan‐Heparin‐Minocycline composite membranes, are prepared from chitosan, heparin, minocycline, and CaCl2 via ion pairing and complexation. These membranes are characterized using Fourier‐transform infrared spectroscopy, scanning electron microscopy, and energy‐dispersive X‐ray spectroscopy. Release kinetics of minocycline from these membranes is evaluated in vitro. Their antibacterial activities are assessed using agar disk diffusion and biofilm assays in vitro. The chemical and physical characterization confirms the successful synthesis of composite membranes. The two types of minocycline‐containing membranes achieve sustained release of minocycline for 17 days and 4 weeks in simulated body fluid, respectively. They demonstrate sustained potent antimicrobial effects against Staphylococcus aureus and Aggregatibacter actinomycetemcomitans in agar disk diffusion assays. Biofilm assays reveal that both minocycline‐containing composite membranes significantly reduce viability of Aggregatibacter actinomycetemcomitans in 7‐day biofilms. These results suggest that these minocycline‐containing composite membranes can be exploited for antibacterial applications in medicine and dentistry.

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Sustained Release of Minocycline From Minocycline-Calcium-Dextran Sulfate Complex Microparticles for Periodontitis Treatment

Cited by 24 publications

References 42 publications

Nanocomplex System of Bupivacaine with Dextran Sulfate for Parenteral Prolonged Delivery

Nanocomplex System of Bupivacaine with Dextran Sulfate for Parenteral Prolonged Delivery

Biomimetic metal-organic nanoparticles prepared with a 3D-printed microfluidic device as a novel formulation for disulfiram-based therapy against breast cancer

Synthesis and Evaluation of Chitosan‐Heparin‐Minocycline Composite Membranes for Potential Antibacterial Applications

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