Sustained-release of naproxen sodium from electrospun-aligned PLLA-PCL scaffolds

Lui, Yuan Siang; Lewis, Mark P.; Loo, Say Chye Joachim

doi:10.1002/term.2000

Cited by 19 publications

(24 citation statements)

References 56 publications

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“…The failure stress was also enhanced with the addition of water as the co-solvent. This NPS-loaded scaffold showed no significant cytotoxicity, and L929 murine fibroblasts cultured on the scaffolds were able to proliferate and align along the fibers [ 71 ].…”

Section: Applications For Tendon and Ligament Regeneration And Repmentioning

confidence: 99%

Biofabrication of Electrospun Scaffolds for the Regeneration of Tendons and Ligaments

2018

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Tendon and ligament tissue regeneration and replacement are complex since scaffolds need to guarantee an adequate hierarchical structured morphology, and non-linear mechanical properties. Moreover, to guide the cells’ proliferation and tissue re-growth, scaffolds must provide a fibrous texture mimicking the typical of the arrangement of the collagen in the extracellular matrix of these tissues. Among the different techniques to produce scaffolds, electrospinning is one of the most promising, thanks to its ability to produce fibers of nanometric size. This manuscript aims to provide an overview to researchers approaching the field of repair and regeneration of tendons and ligaments. To clarify the general requirements of electrospun scaffolds, the first part of this manuscript presents a general overview concerning tendons’ and ligaments’ structure and mechanical properties. The different types of polymers, blends and particles most frequently used for tendon and ligament tissue engineering are summarized. Furthermore, the focus of the review is on describing the different possible electrospinning setups and processes to obtain different nanofibrous structures, such as mats, bundles, yarns and more complex hierarchical assemblies. Finally, an overview concerning how these technologies are exploited to produce electrospun scaffolds for tendon and ligament tissue applications is reported together with the main findings and outcomes.

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Section: Applications For Tendon and Ligament Regeneration And Repmentioning

confidence: 99%

Biofabrication of Electrospun Scaffolds for the Regeneration of Tendons and Ligaments

2018

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“…This step aims at facilitating cell affinity towards the fibers by promoting the recognition of bound growth factors and specific proteins by cell receptors [ 29 , 30 ]. Many authors have chosen to functionalize the electrospun scaffolds and modify their surfaces by blending the polymer solution with bioactive molecules prior to electrospinning [ 19 , 31 , 32 , 33 , 34 ]. Others have used a wet chemistry surface modification approach to functionalize electrospun scaffolds by immersing them into harsh chemicals such as strong acids or alkalis [ 35 , 36 , 37 , 38 , 39 , 40 ] in which hydroxyl or carboxyl groups are formed by hydrolyses of ester bonds.…”

Section: Introductionmentioning

confidence: 99%

Fabrication and Plasma Surface Activation of Aligned Electrospun PLGA Fiber Fleeces with Improved Adhesion and Infiltration of Amniotic Epithelial Stem Cells Maintaining their Teno-inductive Potential

et al. 2020

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Electrospun PLGA microfibers with adequate intrinsic physical features (fiber alignment and diameter) have been shown to boost teno-differentiation and may represent a promising solution for tendon tissue engineering. However, the hydrophobic properties of PLGA may be adjusted through specific treatments to improve cell biodisponibility. In this study, electrospun PLGA with highly aligned microfibers were cold atmospheric plasma (CAP)-treated by varying the treatment exposure time (30, 60, and 90 s) and the working distance (1.3 and 1.7 cm) and characterized by their physicochemical, mechanical and bioactive properties on ovine amniotic epithelial cells (oAECs). CAP improved the hydrophilic properties of the treated materials due to the incorporation of new oxygen polar functionalities on the microfibers’ surface especially when increasing treatment exposure time and lowering working distance. The mechanical properties, though, were affected by the treatment exposure time where the optimum performance was obtained after 60 s. Furthermore, CAP treatment did not alter oAECs’ biocompatibility and improved cell adhesion and infiltration onto the microfibers especially those treated from a distance of 1.3 cm. Moreover, teno-inductive potential of highly aligned PLGA electrospun microfibers was maintained. Indeed, cells cultured onto the untreated and CAP treated microfibers differentiated towards the tenogenic lineage expressing tenomodulin, a mature tendon marker, in their cytoplasm. In conclusion, CAP treatment on PLGA microfibers conducted at 1.3 cm working distance represent the optimum conditions to activate PLGA surface by improving their hydrophilicity and cell bio-responsiveness. Since for tendon tissue engineering purposes, both high cell adhesion and mechanical parameters are crucial, PLGA treated for 60 s at 1.3 cm was identified as the optimal construct.

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“…The incorporation of drugs into scaffolds and the drug release profiles were the predominant outcome measure of several studies 26,34,36,76 . Techniques employed to incorporate the molecules into electrospun scaffolds were varied and included dissolving drugs directly into the electrospinning solution (bFGF 74 , naproxen 36 and hyaluronan) or producing an emulsion with hydrosols (mitomycin C [MMC]). One study made use of bFGF-loaded nanoparticles for drug release 34 .…”

Section: Drug Deliverymentioning

confidence: 99%

“…We found five original research papers looking into delivery of naproxen, celecoxib, Mitomycin C (MMC) and growth factors such as bFGF 26,36,67,74,76 . These molecules were investigated secondary to previously published work suggesting potential efficacy in tendinopathy.…”

Section: Drug Deliverymentioning

confidence: 99%

The Use of Electrospun Scaffolds in Musculoskeletal Tissue Engineering: A Focus on Tendon and the Rotator Cuff

Stace

Nagra

Tiberwel

et al. 2018

CSCR

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Sustained-release of naproxen sodium from electrospun-aligned PLLA-PCL scaffolds

Cited by 19 publications

References 56 publications

Biofabrication of Electrospun Scaffolds for the Regeneration of Tendons and Ligaments

Biofabrication of Electrospun Scaffolds for the Regeneration of Tendons and Ligaments

Fabrication and Plasma Surface Activation of Aligned Electrospun PLGA Fiber Fleeces with Improved Adhesion and Infiltration of Amniotic Epithelial Stem Cells Maintaining their Teno-inductive Potential

The Use of Electrospun Scaffolds in Musculoskeletal Tissue Engineering: A Focus on Tendon and the Rotator Cuff

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