Sustained release of VH and rhBMP-2 from nanoporous magnesium–zinc–silicon xerogels for osteomyelitis treatment and bone repair

Abstract

Nanoporous magnesium–zinc–silicon (n-MZS) xerogels with a pore size ∼4 nm, a surface area of 718 cm 2 /g, and a pore volume of 1.24 cm 3 /g were synthesized by a sol–gel method. The n-MZS xerogels had high capacity to load vancomycin hydrochloride (VH) and human bone morphogenetic protein-2 (rhBMP-2), after soaking in phosphate buffered saline (PBS) for 24 hours (1.5 and 0.8 mg/g, respectively). Moreover, the n-MZS xerogels exhibited the sustained release of VH and rhBMP-2 as compared with magnesium–zinc–silicon (MZS) xerogels without nanopores (showing a burst release). The VH/rhBMP-2/n-MZS system not only exhibited a good antibacterial property but also promoted the MG63 cell proliferation and differentiation demonstrating good bactericidal activity and cytocompatibility. The results suggested that n-MZS with larger surface area and high pore volume might be a promising carrier for loading and sustained release of VH and rhBMP-2. Hence, the VH/rhBMP-2/n-MZS system might be one of the promising biomaterials for osteomyelitis treatment and bone repair.

Microporous Nano-hydroxyapatite/collagen/phosphatidylserine Scaffolds Embedding Collagen Microparticles for Controlled Drug Delivery in Bone Tissue Engineering

“…(ii) control of appropriate release rates upon tissue. (iii) the potentially targeted drug delivery to specific cells, and (iv) the preservation of drug functionality and integrity during construction of the scaffold 5,6 . So far little studies reported how the spatiotemporal control of drug may affect tissue repair.…”

Dual-functional composite scaffolds for inhibiting infection and promoting bone regeneration

“…In the drug delivery system with nanoporous magnesium–zinc–silicon as the carrier, the co-release profile of BMP-2 and vancomycin is not significantly different from that of the two drugs alone, which proves that vancomycin and BMP-2 have no mutual influence on drug diffusion and release ( Fig. 8 ) [ 188 ]. Moreover, vancomycin and the BMP-2 double-drug-loaded silicon-imprinted calcium phosphate scaffold and BMP-2 single-drug-loaded silicon-imprinted calcium phosphate scaffold both significantly promote new bone formation of rat tibial defects.…”

New soluble magnesium-based alloys for use in traumatology

“…Постепенная (в течение семи месяцев) метаболизация металлических фиксаторов из биодеградирующего магниевого сплава МЛ-10 организмом белых беспородных крыс-самцов сопровождалась отсутствием нарушений физиологических проявлений. Исходя из результатов эксперимента, можно рекомендовать металлические фиксаторы из биодеградирующего магниевого сплава МЛ-10 для применения у человека [6,15].…”

“…Поиск оптимальных материалов для остеосинтеза продолжается. Неоднократно исследователи обращали внимание на магний и его сплавы, одним из свойств которых является растворимость в водной среде [6].…”

“…Пластины разрушились через 8 суток, а активное растворение металла сопровождалось выделением большого количества газа [7]. Совершенствование состава магниевого сплава показало, что эти материалы могут быть перспективными для остеосинтеза [6]. Удалось получить сплавы с более приемлемыми характеристиками по скорости растворения.…”