Sustained response of graft-versus-host disease-associated angiomatosis treated with propranolol

Kidambi, Arpita Debroy; Mathew, Bipin; Goodfield, Mark; Laws, Philip

doi:10.1111/ced.13540

Cited by 2 publications

(2 citation statements)

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“…Successful results have been also reported with propranolol in two cases and with topical timolol in one case. 8,9 Unlike our case, none of the previously reported cases of GvHD-AA showed vascular lesions embedded into tissue, which histopathologically and immunohistochemically resembled fat tissue.…”

Section: Discussioncontrasting

confidence: 70%

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Graft‐versus‐host disease‐associated angiomatosis with striking lipomatous metaplasia

et al. 2021

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Sclerodermatous graft-versus-host disease (GvHD) is one of the many clinicopathological variants of chronic GvHD. One of the rarest forms of this variant is GvHDassociated angiomatosis (GvHD-AA). We describe the case of a 62-year-old male with sclerodermatous GvHD who presented, in consecutive years, two different lesions that showed characteristics of GvHD-AA. The first lesion fitted perfectly with the previously known features of this rare entity. However, the second lesion was more interesting, as the angiomatoid lesion was surrounded by newly appeared adipocytes, something not previously described. The appearance of this peculiar adipose tissue may be explained as related to an important dermal atrophy, as a concomitant appearance of a lipomatous nevus and GvHD-AA, or, finally, as mature adipose tissue related to a previous inflammatory process, that is, lipomatous metaplasia. Both lesions were diagnosed as GvHD-AA, and the second one was considered to be associated with dermal lipomatous metaplasia. We also considered whether hypoxia could be related to both lesions. In the present report, we review previously published cases of GvHD-AA and discuss the different hypotheses that could explain the appearance of metaplasia associated with the second lesion.

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Section: Discussioncontrasting

confidence: 70%

“…In our case, after the two surgeries no other vascular lesions have appeared. Successful results have been also reported with propranolol in two cases and with topical timolol in one case 8,9 …”

Section: Discussionmentioning

confidence: 84%

Graft‐versus‐host disease‐associated angiomatosis with striking lipomatous metaplasia

et al. 2021

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Chronic graft-versus-host disease. Part II: Disease activity grading and therapeutic management

Baumrin¹,

Loren²,

Falk³

et al. 2024

Journal of the American Academy of Dermatology

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Sustained response of graft-versus-host disease-associated angiomatosis treated with propranolol

Abstract: Click https://www.wileyhealthlearning.com/ced.aspx for the corresponding questions to this CME article.

Cited by 2 publications

References 1 publication

Graft‐versus‐host disease‐associated angiomatosis with striking lipomatous metaplasia

Graft‐versus‐host disease‐associated angiomatosis with striking lipomatous metaplasia

Chronic graft-versus-host disease. Part II: Disease activity grading and therapeutic management

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