Sustained virologic response following HCV eradication in two brothers with X-linked agammaglobulinaemia

Houlihan, Diarmaid D.; Storan, Eoin R.; Lee, John M.

doi:10.3748/wjg.15.3944

Cited by 2 publications

(1 citation statement)

References 16 publications

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“…Reports of natural recovery from acute HCV infection by agammaglobulinemic twin children 27 and a sustained virologic response after treatment of 2 brothers with X-linked agammaglobulinemia 28 lend further evidence to the nonprotective role of anti-HCV compared with the crucial importance of CMI responses in resolving infections.…”

Section: Discussionmentioning

confidence: 96%

Hepatitis C Virus-Specific Cell-Mediated Immune Responses in Children Born to Mothers Infected with Hepatitis C Virus

El-Kamary

Hashem

Saleh

et al. 2013

The Journal of Pediatrics

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ObjectiveTo investigate the association between hepatitis C virus (HCV)-specific cell-mediated immunity (CMI) responses and viral clearance in children born to mothers infected with HCV.Study designA cross-sectional study of children from a mother-infant cohort in Egypt were enrolled to detect CMI responses to recombinant core and nonstructural HCV antigens (nonstructural segments NS3, NS4a/b, and NS5 of the HCV genome) using an interferon-gamma enzyme-linked immunospot assay. Children born to mothers with chronic HCV were enrolled into 3 groups: transiently viremic (n = 5), aviremic (n = 36), and positive control (n = 6), which consisted of 1 child with chronic HCV from this cohort and another 5 children with chronic HCV from a companion study. Children without HCV born to mothers without HCV (n = 27) served as a negative control group. Wilcoxon rank sum test was used to compare the magnitude of CMI responses between groups.ResultsNone of the 6 control children who were positive for HCV responded to any HCV antigen, and 4 (80%) of 5 children with transient viremia responded to at least one HCV antigen, compared with 5 (14%) of 36 and 3 (11%) of 27 children in the aviremic and negative control groups, respectively. Children with transient viremia elicited stronger responses than did negative controls (P = .005), positive controls (P = .011), or children without HCV viremia (P = .012), particularly to nonstructural antigens.ConclusionsHCV-specific CMI responses were significantly higher in magnitude and frequency among transiently infected children compared with those persistently infected. This suggests CMI responses may be associated with past viral clearance and can identify children at high risk of infection, who can be targeted for health education, screening, and follow-up.

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Section: Discussionmentioning

confidence: 96%