Sutureless Amniotic Membrane Transplantation in Inflammatory Corneal Perforations

Meduri, Alessandro; Valastro, Antonio; Oliverio, Giovanni William; Ninotta, Ivan; Camellin, Umberto; Mancini, Maura; Roszkowska, Anna M.; Aragona, Pasquale

doi:10.3390/app12083924

Cited by 4 publications

(2 citation statements)

References 44 publications

(49 reference statements)

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“…In a study in which the anterior chamber was lled with C3F gas in addition to hAM transplantation, the success rate was reported to be 100%. 7 Meduri et al 17 reported the e cacy of sutureless amniotic membrane transplantation in 12 eyes with in ammatory pathologies. They de ned the surgical procedure in their study as two layers of hAM and the application of a therapeutic contact lens on two layers, followed by striated seamless tarsorrhaphy, and reported resolution in all patients.…”

Section: Discussionmentioning

confidence: 99%

Sandwich Technique and Amniotic Membrane Transplantation as an Effective Method in Repairing Corneal Perforations

Ciftci¹,

Selver

2023

Preprint

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Purpose To evaluate effectiveness of human amniotic membrane (hAM) transplantation in patients with non-traumatic corneal perforation. Methods This retrospective chart review included the patients who were underwent hAM transplantation with sandwich technique between March 2020 to January 2023 at Ege University Hospital, Turkey. Medical records of the patients including demographic data, best corrected visual acuity (BCVA) that was measured with Snellen chart, detailed ophthalmological examination and the need for additional surgical intervention after hAM transplantation were evaluated. Complications, anatomical and functional results were presented. Results A total 9 eyes of 9 patients with non-traumatic corneal perforations were evaluated between 2020 and 2023. Size of perforation was ≤ 3 mm in all the eyes. The mean age of the patients was 67.77 ± 15.52. Female to male ratio was 1/8. Sandwich technique was used in all patients for hAM transplantation. Five of cases (55.55%) had infectious etiology and 4 of them (44.44%) had inflammatory etiology. Of the infectious corneal perforations, 3 (33.33%) were herpes simplex virus-induced neurotrophic keratopathy and 2 (22.22%) were bacterial keratitis. The mean residence time of the amniotic membrane on the ocular surface was 21 ± 8.05 days. Tectonic keratoplasty was needed in 1 eye (11.11%). Corneal patch grafting was required in 1 of eyes (11.11%). Evisceration was performed in 1 eye (11.11%) of a patient with no light perception who had no visual prognosis. Amniotic membrane detachment was observed in one patient as a surgical-related complication associated with hAM transplantation. Conclusions hAM transplantation is one of the successful treatment methods in treatment of relatively small corneal perforation. Considering the difficulty of finding a donor cornea and the easier access to the amniotic membrane, it seems like a good alternative treatment to reduce or postpone the need for tectonic keratoplasty.

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Section: Discussionmentioning

confidence: 99%

Sandwich Technique and Amniotic Membrane Transplantation as an Effective Method in Repairing Corneal Perforations

Ciftci¹,

Selver

2023

Preprint

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“…In some patients with severe corneal pathologies, such as chemical burns, autoimmune disease, Steven-Johnsons syndrome, and severe dry eye, amniotic membrane transplantation or corneal transplantation was mostly used in the past, but the curative effect was not ideal because of poor ocular surface conditions or inflammatory reactions caused by the sutures (1). Although it has been reported that the use of sutureless amniotic membrane transplantation improves the efficacy, large studies are still needed (2).…”

Section: Introductionmentioning

confidence: 99%

Timing of glaucoma treatment in patients with MICOF: A retrospective clinical study

Zhao

Wang²,

Zhang³

et al. 2022

Front. Med.

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PurposeTo summarize and discuss the treatment and timing of glaucoma in patients with MICOF keratoprosthesis implantation to guide follow-up clinical treatment.MethodsThe data of 39 eyes (39 patients) with the Moscow Eye Microsurgery Complex in Russia (MICOF) keratoprosthesis implantation in our hospital from 1 January 2002 to 31 December 2017 were collected, including patients with preexisting glaucoma and those who developed glaucoma de novo after MICOF. The sex, age, preoperative diagnosis, glaucoma surgery, keratoplasty, times of keratoplasty, best corrected visual acuity (BCVA) and final follow-up corrected visual acuity, visual field (VF) defect, and cup-to-disk ratio (CDR) were statistically analyzed.ResultsAmong 16 eyes with preexisting glaucoma, eight eyes underwent glaucoma surgery before MICOF, 4 eyes underwent glaucoma surgery combined with MICOF, and four eyes were managed medically. Among 23 eyes with de novo glaucoma, seven eyes were treated with surgery and 16 eyes were treated with medication only. A total of 9 (56.3%) eyes had corneal transplants with preexisting glaucoma, which was a higher percentage than that in the patients with de novo glaucoma (n = 5, 21.7%, P = 0.043). In both the preexisting glaucoma group and the de novo glaucoma group, the most common causes were alkali burns (56.3% of preexisting glaucoma and 43.5% of de novo glaucoma). There was no significant difference between the operation and initial visual acuity, postoperative visual acuity, BCVA, CDR, or VF defect. In the de novo glaucoma group, the final follow-up visual acuity of the glaucoma surgery group (1.56 ± 1.07) was worse than that of the mediation group (0.44 ± 0.53) (P < 0.017). Among the complications, the incidence of cornea melting in the patients treated with medications only (n=10) was significantly higher than that in the patients treated with glaucoma surgery (n = 0, P = 0.007), but there was no significant difference in the other complications.ConclusionAmong patients with MICOF, those patients who have undergone keratoplasty are more likely to develop glaucoma before surgery and glaucoma needs to be prevented. Surgical treatment can be selected according to the ocular surface condition in the patients with de novo glaucoma to reduce the occurrence of complications.

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A comparative study between amniotic membrane transplantation and topical mitomycin-C in recurrent pterygium management

El-Shahed,

Yousef

et al. 2024

Delta Journal of Ophthalmology

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Aim The aim of this study was to compare the outcome of amniotic membrane transplantation (AMT) and topical mitomycin-C (MMC) in the management of recurrent pterygia. Patients and methods This is a retrospective study that included 40 cases of recurrent pterygia. They were subjected to surgical excision of the pterygium with bare sclera technique. The cases were categorized into two groups, 20 cases in each group. Group 1 was managed with intraoperative topical MMC, while group 2 was managed with AMT at the time of surgery. The patients were followed-up for at least 6 months postoperatively. The outcome measures were visual acuity (VA), corneal astigmatism, recurrence, and postoperative complications. Results The duration of postoperative pain was significantly shorter in the AMT group (6.8±1.0 days) than in the MMC group (10.45±1.5 days, P<0.0001). In addition, postoperative photophobia and lacrimation persisted for a significantly longer period in the MMC group (mean=10.0±1.03 days) compared to the AMT group (mean=7.85±0.81 days, P<0.0001). At the end of follow-up period, VA improvement occurred in 60% of group 1 and in 70% of group 2 patients. However, the preoperative and postoperative decimal VA were not significantly different between the two study groups (P=0.6684 and 0.7302, respectively). In group 1, there was a significant difference between the preoperative corneal astigmatism [−3.74±2.19 diopter (D)] and the postoperative astigmatism (−2.31±1.46 D) after 6 months (P<0.01). Similarly, in group 2, there was also a significant difference between the preoperative corneal astigmatism (−3.83±2.32 D) and the postoperative astigmatism (−2.12±1.60 D) after 6 months (P<0.01). However, the difference between the two groups was statistically insignificant. In the first postoperative 2 weeks, there was a statistically insignificant higher incidence of delayed wound healing and superficial punctate keratitis in the MMC group. The corneal wound healing was faster in the AMT group (mean=4.2±0.69 days) than in the MMC group (mean=4.6±o.6 days). However, the difference was not statistically significant (P=0.0578). At 2 weeks postoperatively, there were two cases of conjunctival defect and one case of scleral thinning in the MMC group only. At the end of the follow-up period, another case, in the MMC group, developed scleral thinning; however, the cornea was clear. Conclusion AMT and MMC could be used in the management of recurrent pterygia. The AMT group showed better visual outcome without postoperative complications. However, the difference between the two groups was statistically insignificant.

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Sutureless Amniotic Membrane Transplantation in Inflammatory Corneal Perforations

Cited by 4 publications

References 44 publications

Sandwich Technique and Amniotic Membrane Transplantation as an Effective Method in Repairing Corneal Perforations

Sandwich Technique and Amniotic Membrane Transplantation as an Effective Method in Repairing Corneal Perforations

Timing of glaucoma treatment in patients with MICOF: A retrospective clinical study

A comparative study between amniotic membrane transplantation and topical mitomycin-C in recurrent pterygium management

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