SUV39H1 is a prognosis and immune microenvironment-related biomarker in diffuse large B-cell lymphoma

Zhang, Yue; Qian, Siyu; Wen, Qing; Lei, Yaxin; Ge, Jingjing; Kong, Xiaoshuang; Wang, Wenhua; Wang, Zeyuan; Hou, Huting; Tang, Canwei; Wu, Shihao; Wang, Guannan; Li, Wencai; Zhang, Mingzhi; Zhang, Xudong; Chen, Qingjiang

doi:10.1007/s12094-023-03128-2

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Cited by 3 publications

References 35 publications

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SUV39H1 Regulates Gastric Cancer Progression via the H3K9me3/ALDOB Axis

Li,

Liu,

Gao

2024

Cell Biochem Biophys

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SUV39H1 Regulates Gastric Cancer Progression via the H3K9me3/ALDOB Axis

Li,

Liu,

Gao

2024

Cell Biochem Biophys

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TCFL5 knockdown sensitizes DLBCL to doxorubicin treatment via regulation of GPX4

Zhang

Xie

2023

Cellular Signalling

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SUV39H1 Preserves Cancer Stem Cell Chromatin State and Properties in Glioblastoma

Li,

Xie,

Ghosh

et al. 2024

Preprint

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Of the more than 100 types of brain cancer, glioblastoma (GBM) is the deadliest. As GBM stem cells (GSCs) are considered to be responsible for therapeutic resistance and tumor recurrence, effective targeting and elimination of GSCs could hold promise for preventing GBM recurrence and achieving potential cures. We show here that SUV39H1, which encodes a histone-3, lysine-9 methyltransferase, plays a critical role in GSC maintenance and GBM progression. Upregulation of SUV39H1 was observed in GBM samples compared to normal brain tissues, and knockdown of SUV39H1 in patient-derived GSCs impaired their proliferation and stemness. Single-cell RNA-seq analysis demonstrated restricted expression of SUV39H1 is in GSCs relative to non-stem GBM cells, likely due to super-enhancer-mediated transcriptional activation, while whole cell RNA-seq analysis revealed that SUV39H1 regulates G2/M cell cycle progression, stem cell maintenance, and cell death pathways in GSCs. By integrating the RNA-seq data with ATAC-seq (assay for transposase-accessible chromatin followed by sequencing), we further demonstrated altered chromatin accessibility in key genes associated with these pathways following SUV39H1 knockdown. Treatment with chaetocin, a SUV39H1 inhibitor, mimicked the functional effects of SUV39H1 knockdown in GSCs and sensitized GSCs to the GBM chemotherapy drug temozolomide. Furthermore, targeting SUV39H1 in vivo using a patient-derived xenograft model for GBM inhibited GSC-driven tumor formation. This is the first report demonstrating a critical role for SUV39H1 in GSC maintenance. SUV39H1-mediated targeting of GSCs could enhance the efficacy of existing chemotherapy, presenting a promising strategy for improving GBM treatment and patient outcomes.

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SUV39H1 is a prognosis and immune microenvironment-related biomarker in diffuse large B-cell lymphoma

Cited by 3 publications

References 35 publications

SUV39H1 Regulates Gastric Cancer Progression via the H3K9me3/ALDOB Axis

SUV39H1 Regulates Gastric Cancer Progression via the H3K9me3/ALDOB Axis

TCFL5 knockdown sensitizes DLBCL to doxorubicin treatment via regulation of GPX4

SUV39H1 Preserves Cancer Stem Cell Chromatin State and Properties in Glioblastoma

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