Suxamethonium: A New Look at Pretreatment

Masey, S.A.; Glazebrook, C.W.; Goat, V. A.

doi:10.1093/bja/55.8.729

Cited by 12 publications

(2 citation statements)

References 14 publications

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“…In practice, this aim was not entirely realized. As reported by previous authors [5,6,9,10], a variable proportion of patients develop fasciculations after pretreatment ("selftaming") with suxamethonium. In the present study, this phenomenon was observed in two patients; it was not considered to invalidate the results of the investigation.…”

Section: Discussionsupporting

confidence: 61%

“…Sixty identical 1.1-ml ampoules containing 0.9% saline, suxamethonium 10 mg ml" 1 , gallamine 20 mg ml~l or pancuronium 1 mg ml" 1 were prepared by the Pharmacy Manufacturing Department of the Royal Liverpool Hospital. Similar doses of suxamethonium and gallamine have been used in many previous studies [5][6][7]. The doses of pancuronium 1 mg and gallamine 20 mg were considered to have equipotent effects on neuromuscular transmission.…”

Section: Methodsmentioning

confidence: 99%

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Differential Effects of Neuromuscular Blocking Agents on Suxamethonium-Induced Fasciculations and Myalgia

Sullivan

Williams

Calvey

1988

British Journal of Anaesthesia

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The effect of pretreatment with suxamethonium, gallamine or pancuronium on suxamethonium-induced fasciculations and myalgia was studied in a controlled, randomized and double-blind clinical trial. Both fasciculations and myalgia were assessed on a four-point rating scale. There was no significant correlation between fasciculations and postoperative muscle pain at 24, 48 or 72 h, and pretreatment with suxamethonium had no significant effect on fasciculations or myalgia. Gallamine had a more marked effect on fasciculations than pancuronium, and the decrease in the fasciculation score was statistically significant. In contrast, pancuronium had a greater effect on myalgia, and decreased postoperative muscle pain significantly at 24 and 48 h. These differences may reflect the differential activity of gallamine and pancuronium at the neuromuscular junction. Pretreatment had little or no effect on plasma potassium concentrations.

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Section: Discussionsupporting

confidence: 61%

Section: Methodsmentioning

confidence: 99%

Differential Effects of Neuromuscular Blocking Agents on Suxamethonium-Induced Fasciculations and Myalgia

Sullivan

Williams

Calvey

1988

British Journal of Anaesthesia

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Rocuronium prevents succinylcholine-induced fasciculations

1997

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F. Donati PhD MD FRCFCP~'po~: The aim of this study was to assess the effect of rocuronium pretreab-,ent at 3 and 1.5 min before sucdnytcholine administration on fasdculations, neuromuscular blockade and intubating conditions.Methods: Sixty ASA I or II adults scheduled for elective surgery were anae~etised with midazolam, fentanyl, propofol, N20 and isoflurane. They were randomised in a double blind manner into three groups: group ROC-3 rain (n = 22) received 0.05 mg'kg -I rocuronium, 3 min before 2 rng-kg -I sucdnylcholine; group ROC-1,5 min (n = 20) received 0.05 mg.kg -j rocuronium 1.5 min before 2 mg'kg -I succinylcholine; and group NO ROC (n = 18) had no rocuronium before injection of 2 mg-kg -I sucdnytcholine. Fasciculations and intubating conditions were evaluated by the same physidan who was unaware of the randomisat]on. Neuromuscular block was measured at the adductor pollicis with an accelerometer. Results: The incidence of fasciculations was lower in the ROC-3 rain (9%) and ROC-1.5 rain (30%) groups than in the NO ROC group (83%; P < 0.00 I). The intensity of fasciculations was also less in both p~nt groups. No statistical difference was noted between pretreatment at 3 and 1.5 rain. Intubating conditions, onset time and duration of succinylcholine blockade were comparable in all three groups. Conclusion:The incidence and severity ofsucdnylcholine fasciculations can be reduced by giving 0.05 mg.kg -I rocuronium either 1.5 rain or 3 rain before succinylcholine. The effects of 2 mg-kg -I succinylcholine with rocuronium pretmatment, and I mg-kg -j succinyIcholine, without pretreatment, are similar with respect to intubating conditions, onset of paralysis and duration of blockade.Objectif : ~valuer I'influence du rocuronium administr6 3 et 1,5 min avant la succinytcholine sur les fasciculations, le bloc neuromusculalre et les conditions d'intubation, M~d~odes : Soixante patients ASA Iet II programmds pour une chirurgie non urgente ont dt6 anesth~si6s avec du miclazolam, du fentanyl, du propofol et de I'isoflurane. IIs ont 6t6 assignds al6atoirement et en double aveugle trois groupes : le groupe ROC-3 min (n = 22) a regu le rocuronium 0,05 mg.kg -~ 3 min avant la succinylcholine 2 mg-kg -~ ; le groupe ROC-1,5 min (n = 20) a re(iu le rocuronium 0,05 mg.kg -~ 1,5 min avant la succinytcholine 2 mg-kg -jet le groupe NO ROC (n = 18) n'a pas re~u de rocuronium avant I'injection de la succinylcholine I mg.kg -~. Un m~me m6decin non inform~ de la randomisation a ~alu6 les fasciculations et les conditions d'intubation. Un acc61drom~re a servi ~ mesurer le bloc neuromusculaire au niveau de I'adducteur du pouce.IMmdtats : l'incidence des fasdculations ~ plus bible dans les groupes ROC-3 min (9%) et ROC-1,5 min (30%) que dans le groupe NO ROC (83% ; P < 0,001 ). Les fasciculations ~taient aussi moins intenses dans les deux groupes pr~'-ait6s mais sans diff6rence statistique entre 3 et 1,5 rain. Les conditions d'intubation, la vitesse d'installation et la dur~e d'action du bloc ~ la succinylcholine ne diff6raient pas en...

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Suxamethonium Myalgia

1988

The Lancet

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Suxamethonium: A New Look at Pretreatment

Cited by 12 publications

References 14 publications

Differential Effects of Neuromuscular Blocking Agents on Suxamethonium-Induced Fasciculations and Myalgia

Differential Effects of Neuromuscular Blocking Agents on Suxamethonium-Induced Fasciculations and Myalgia

Rocuronium prevents succinylcholine-induced fasciculations

Suxamethonium Myalgia

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