Suxamethonium induced myalgia and the effect of pre‐operative administration of oral aspirin

McLoughlin, Cormac; Nesbitt, G. A.; Howe, Jo

doi:10.1111/j.1365-2044.1988.tb06689.x

Cited by 44 publications

(18 citation statements)

References 21 publications

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“…Postoperative myalgia associated with the use of suxamethonium is a common clinical problem. The overall incidence of myalgia and fasciculations in the present study is similar to the untreated control groups of other studies which were primarily designed to assess the influence of various pretreatments in attenuating myalgia and fasciculations caused by suxamethonium [2,5,6,11,13,14]. Administration of suxamethonium either immediately or 2 min after the induction agent had no influence on the incidence of myalgia.…”

Section: Discussionsupporting

confidence: 78%

Myalgia and biochemical changes following suxamethonium after induction of anaesthesia with thiopentone or propofol

Maddineni¹,

Mirakhur²,

Cooper

1993

Anaesthesia

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SummaryThe incidence and severity of muscle pains and changes in creatine kinase were assessed following administration of I mg.kg-' suxamethonium either immediately or 2 min after induction of anaesthesia with propofol or thiopentone in patients undergoing elective dental and ophthalmic surgery. The incidence of muscle pains was 35 and 60% respectively in the groups given suxamethonium immediately and 2 min after propofol, and 35 and 55% when given immediately and 2 min after thiopentone.with no statistically significant diflerences among the groups. Creatine kinase levels increased in all the groups after operation with the least average increase in the group receiving suxamethonium immediately after propofol and the highest increase in the group receiving suxamethonium 2 min after thiopentone. There was no correlation between the incidence and severity of fasciculations. muscle pains and changes in creatine kinase within or between the groups. It is concluded that neither the induction agent nor the time between the induction agent and suxamethonium administration has any signijicant injluence on the incidence of muscle pains or creatine kinase elevation following suxamethonium.

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Section: Discussionsupporting

confidence: 78%

Myalgia and biochemical changes following suxamethonium after induction of anaesthesia with thiopentone or propofol

Maddineni¹,

Mirakhur²,

Cooper

1993

Anaesthesia

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“…The wide range of reported incidences probably represents poor standardisation of variables between studies. Gender does not seem to be a factor as was once thought (McLoughlin et al 1988). Gender does not seem to be a factor as was once thought (McLoughlin et al 1988).…”

Section: Myalgiasmentioning

confidence: 89%

Adverse Effects of Depolarising Neuromuscular Blocking Agents

1994

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Muscle relaxants block neuromuscular transmission, acting at nicotinic acetylcholine receptors of the neuromuscular junction. Suxamethonium (succinylcholine) is a depolarising agent, whereas all other relaxants in clinical use are nondepolarising. The desired neuromuscular block results from the structural similarity of muscle relaxants to acetylcholine, enabling the interaction with receptors at the neuromuscular junction. Adverse effects of suxamethonium are generally related to its agonist mode of action. Autonomic cardiovascular effects may result. Other adverse effects include anaphylactic or anaphylactoid reactions, and histamine release. Various disease states may present specific considerations in the use of muscle relaxants. Although many complications of muscle relaxants (such as prolonged block or resistance) are easily treated, others may require immediate intervention and vigorous therapy. Careful selection of appropriate relaxants for particular patients will usually prevent the occurrence of complications.

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“…Aspirin at an oral dose of 600 mg, 1 h before the induction of anaesthesia has been used successfully to reduce postoperative myalgia in patients without peptic ulcer or known allergy [6]. Aspirin does not seem capable of preventing significant increases in postoperative creatine kinase [9].…”

Section: Discussionmentioning

confidence: 99%

“…This has led to the employment of agents possessing antioxidant properties such as α‐tocopherol, in an attempt to minimise pain. A number of other drugs such as nondepolarizing muscle relaxants, intravenous benzodiazepines, aspirin and lignocaine, have also been used [5–8]. Alternatively, suxamethonium has been administered either in small increments [8] or with thiopentone to reduce postoperative muscle pain [9].…”

mentioning

confidence: 99%

Continuous propofol administration for suxamethonium‐induced postoperative myalgia

et al. 1999

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SummaryThe effect of continuous propofol administration on creatine kinase and suxamethonium-induced postoperative myalgia was evaluated in 50 patients randomised into two groups of 25 patients each. Induction of anaesthesia was identical in all patients. Anaesthesia was maintained with 66% nitrous oxide in oxygen supplemented by either isoflurane 1% or continuous propofol. Creatine kinase was measured before and after operation. Myalgia was evaluated postoperatively by a blinded observer. The median level of myalgia was reduced significantly in the continuous propofol group (p ¼ 0.011). The median creatine kinase value increased significantly in the isoflurane group (from 90 to 160 IU, p ¼ 0.001).

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Suxamethonium induced myalgia and the effect of pre‐operative administration of oral aspirin

Cited by 44 publications

References 21 publications

Myalgia and biochemical changes following suxamethonium after induction of anaesthesia with thiopentone or propofol

Myalgia and biochemical changes following suxamethonium after induction of anaesthesia with thiopentone or propofol

Adverse Effects of Depolarising Neuromuscular Blocking Agents

Continuous propofol administration for suxamethonium‐induced postoperative myalgia

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