Suzuki-Miyaura Çapraz Eşleşme Reaksiyonunda Katalizör Olarak Heterosiklik Bileşiklerin Uygulanması

Abstract

Four different benzimidazolium salts (1-4) were prepared in three steps at 80 o C and their structures were elucidated using spectroscopic methods. The compounds (1-4) obtained were tested in in situ medium as catalyst in the carbon-carbon (C-C) bond formation reactions of two different boronic acid derivatives with various aryl halides in the presence of palladium acetate (PdOAc)2 and sodium tertiarybutoxide (NaOBu t) as a base. With this reaction, four coupling products (5-8) were synthesized in different yields ranging from 11 to 93%. Compound 2 from the carbene precursors tested in the Suzuki-Miyaura cross-coupling reaction was found to be a more effective catalyst candidate than others.

Importance of some factors on the Suzuki‐Miyaura cross‐coupling reaction

“…Therefore, numerous compounds have been synthesized by different research groups to obtain the most effective catalyst in the SMC reaction. [ 34,44–52 ]…”