Suzuki-Miyaura cross-coupling reaction of monohalopyridines and l-aspartic acid derivative

Recent Advances in Metal-Catalyzed Alkyl–Boron (C(sp3)–C(sp2)) Suzuki-Miyaura Cross-Couplings

“…in THF (Scheme 7B). The experimental yield gave insight on the reactivity order of halogen substituents and position, which was found to be as follows: Br > I >> Cl and C3 > C2, C4 [89]. Although decarbonylative and acyl cross-coupling reactions are not covered in this review [48][49][50][51][52]90], it is worth mentioning two very recent novel reports from the groups of Rueping and Nishihara.…”

“…in THF (Scheme 7B). The experimental yield gave insight on the reactivity order of halogen substituents and position, which was found to be as follows: Br > I >> Cl and C3 > C2, C4 [89]. Very recently, Newhouse et al described the use of β-triflyl enones 32 as efficient coupling partners in a mild B-alkyl SMC (Pd(dppf)Cl 2 (2.5 mol%), Cs 2 CO 3 (2 eq.…”

“…in THF (Scheme 7B). The experimental yield gave insight on the reactivity order of halogen substituents and position, which was found to be as follows: Br > I >> Cl and C3 > C2, C4 [89].…”