With the burgeoning advancement of online education, transitioning traditional courses into online open courses tailored to individual learner needs has emerged as a novel challenge for numerous universities and educational institutions. This manuscript delineates the development trajectory of an online open course in Preventive Medicine anchored in post-competence principles. Recommendations are posited, encompassing course objectives, content structuring, pedagogical strategies, and resource development, to enhance the course's efficacy and relevance.