Sweat-gland Tumours: A Clinical Review of Cases in One Centre Over 20 Years

Hall, James A.; Knee, G.; A’Hern, Roger; Clarke, Jeffrey; Glees, J.P.; Ford, H. T.; Eeles, Rosalind

doi:10.1016/j.clon.2005.12.011

Cited by 16 publications

(26 citation statements)

References 30 publications

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“…The carcinoma expands regionally in early stage, and hematogenous spread or bone metastasis may occur subsequently. 5 The relationship between them has drawn much attention.…”

Section: Discussionmentioning

confidence: 99%

Clinicopathologic characteristics of extramammary Paget’s disease of the scrotum associated with sweat gland adenocarcinoma—a clinical retrospective study

Dong

Dai

Jin

et al. 2011

Journal of the Chinese Medical Association

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Extramammary Paget's disease of the scrotum with sweat gland adenocarcinoma is a rare malignant tumor. This study aims to summarize the clinicopathologic characteristics related to the prognosis of scrotal Paget's disease with underlying sweat gland adenocarcinoma. Clinical datum of four patients with scrotal Paget's disease with sweat gland carcinoma, treated in Beijing Chao-Yang Hospital from 2002 to 2009 was analyzed, and a literature review was conducted. The typical manifestation of scrotal Paget's disease with sweat gland carcinoma was eczematoid-like skin lesions. All patients underwent primary lesion resection plus inguinal lymphadenectomy. Three patients had inguinal lymph metastasis. One of them developed distant metastases in bone and bone marrow and died of metastatic carcinoma. The dead patient had higher serum carcinoma embryonic antigen (CEA) level, Her-2 overexpression and shorter disease course than the other patients. The other patients were observed for at least 3 years, and lived without tumor. Scrotal Paget's disease with sweat gland adenocarcinoma may be prone to inguinal lymph node and bone metastasis. Serum CEA level, Her-2 overexpression, dermis and lymphovascular invasion may be associated with the prognosis of scrotal Paget's disease with sweat gland adenocarcinoma. The primary lesion resection plus inguinal lymphadenectomy is the major treatment for scrotal Paget's disease with sweat gland adenocarcinoma. The effect of combination chemotherapy in the treatment of metastatic extramammary Paget's disease remains to be proven by prolonged follow-up and wide experience.

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“…The carcinoma expands regionally in early stage, and hematogenous spread or bone metastasis may occur subsequently. 5 The relationship between them has drawn much attention.…”

Section: Discussionmentioning

confidence: 99%

Clinicopathologic characteristics of extramammary Paget’s disease of the scrotum associated with sweat gland adenocarcinoma—a clinical retrospective study

Dong

Dai

Jin

et al. 2011

Journal of the Chinese Medical Association

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“…Sweat gland tumours are exceedingly rare with estimates suggesting they account for as little as 0.005% of all skin tumours 3 . Furthermore, when considering the sweat gland carcinomas, some studies in the United States have reported incidences around 0.05%…”

Section: Discussionmentioning

confidence: 99%

“…We presented here a case of left pectoral region hidradenocarcinoma of which very few cases are present in the literature. Hidradenocarcinoma is a sweat gland tumour arising from eccrine sweat glands which open directly onto the skin, not apocrine glands which are specialised sweat glands that arise in association with hair follicles 3 . The distinction is important in that eccrine glands can exist literally anywhere on the skin surface whereas apocrine glands are concentrated in hair-rich environments such as the axilla, groin, perineum and eyelids 3 .…”

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confidence: 99%

A Rare Case Of Pectoral Hidradenocarcinoma And Brief Review

2011

IJS

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Sweat gland tumours are in general uncommon and particular the malignant variety. Hidradenocarcinoma is one malignant variant with exceedingly low incidence with some studies reporting an incidence of 0.05% 1. Although rare, these tumours have a significant metastatic potential and given the relative paucity of published data with only just over 50 case reports and small case series, there is little information available on the natural history and appropriate management for this disease 2. Perianal, scalp, abdominal and distal extremity lesions have been reported; however, there are few reported cases of hidradenocarcinomas on the chest and pectoral region. We report below a rare case of hidradenocarcinoma in a male presenting as a cystic lesion on the left pectoral area. We provide a short review on hidradenocarcinomas and treatments currently applied.

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“…Cisplatin/5‐fluorouracil‐based combination chemotherapy is known to have synergistic antineoplastic activity in various adenocarcinomas 5 . Cetuximab is a recombinant, human–murine chimeric monoclonal antibody and specifically targets the EGFR 6 . It has also been proven to have synergic effects when combined with other chemotherapeutic agent or radiotherapy in many visceral malignancies 7 .…”

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confidence: 99%

“…5 Cetuximab is a recombinant, human-murine chimeric monoclonal antibody and specifically targets the EGFR. 6 It has also been proven to have synergic effects when combined with other chemotherapeutic agent or radiotherapy in many visceral malignancies. 7 The present EA shows positive staining for EGFR, which makes the use of cetuximab rational.…”

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confidence: 99%

Giant eccrine adenocarcinoma with skin and lymph node metastases: favourable response to chemotherapy

Lin

Tai

Lee

et al. 2009

Acad Dermatol Venereol

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4 Kroeger KM, Carville KS, Abraham LJ. The -308 tumor necrosis factor-alpha promoter polymorphism effects transcription. Mol Immunol 1997; 34: 391-399. 5 Javor J, Bucova M, Ferencik S, Grosse-Wilde H, Buc M. Single nucleotide polymorphisms of cytokine genes in the healthy Slovak population. Int J Immunogenet 2007; 34: 273-280. 6 Paraskevaidis A, Drakoulis N, Roots I et al. Polymorphisms in the human cytochrome P-450 1A1 gene (CYP1A1) as a factor for developing acne. Dermatology 1998; 196: 171-175. 7 Sobjanek M, Zablotna M, Sokolowska-Wojdylo M. Polymorphism in cytochrome P-450 (CYP1A1) in acne vulgaris: preliminary study. Post Dermatol Alergol 2007; 24: 69-72. 8 He L, Yang Z, Yu H et al. The relationship between CYP17 -34T/C polymorphism and acne in Chinese subjects revealed by sequencing. EditorA 45-year-old man presented with a complaint of a 4-month history of two progressively enlarging skin tumours, one each on the occipital scalp and nape (Fig. 1a,b). Initially, the scalp lesion began first, and the nape lesion developed a few days later. Multiple enlarged lymph nodes could be palpated in the neck and supraclavicular area. Incisional biopsies of both lesions were

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Sweat-gland Tumours: A Clinical Review of Cases in One Centre Over 20 Years

Cited by 16 publications

References 30 publications

Clinicopathologic characteristics of extramammary Paget’s disease of the scrotum associated with sweat gland adenocarcinoma—a clinical retrospective study

Clinicopathologic characteristics of extramammary Paget’s disease of the scrotum associated with sweat gland adenocarcinoma—a clinical retrospective study

A Rare Case Of Pectoral Hidradenocarcinoma And Brief Review

Giant eccrine adenocarcinoma with skin and lymph node metastases: favourable response to chemotherapy

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