Sweat osmolality in Down's syndrome and cystic fibrosis in an Indian population.

Abstract

PI blockers who require a calcium antagonist for the treatment of angina are prescribed one that has no effect on cardiac conducting tissue.We thank Mrs Sheila Haugh for typing this manuscript.

Increased Sweat Sodium Concentration in Patients with Alzheimer's Disease

“…In this study, the healthy women had a mean sodium concentration of 62 mmol/1. This was in accor dance with a previous study of sweat osmolality in an Indian population which showed an upper limit of 160 mmol/kg, corresponding to about 65 mmol/1 sodium and potassium [4], That study showed no age correlation and somewhat higher values in women. O ur results were somewhat higher than the 25 mmol/1 chloride and sodium found by Davies et al [3] in healthy subjects with a mean age of 53 years, ranging from 18 to 85 years [3], 18% of the control women reported a diminished sweating ability.…”

“…In a previous study of 20 patients with Down's syn drome the mean sweat osmolality was 228 mmol/kg, cor responding to a sodium and potassium level of about 110 mmol/1 and similar to the mean value of 91 mmol/1 in our AD patients [4]. All patients in that study had values higher than 160 mmol/kg [4], Patients with Down's syn drome develop cognitive reduction and a dementia-like state in the 4th-6th decades.…”

“…All patients in that study had values higher than 160 mmol/kg [4], Patients with Down's syn drome develop cognitive reduction and a dementia-like state in the 4th-6th decades. The same neuropathological AD changes are found in patients dying from Down's syn drome in middle age or later.…”

“…This was in accor dance with a study of sweat osmolality in Down's syn drome in which 10% of the patients showed no response compared to 3% in the general population [4], Davies et al [3] found no sex differences in sweat response using the Gibson and Cooke technique when they studied 200 adults, healthy controls and those with pulmonary' disor ders [3]. However, a diminished sweat response in the elderly, with a more pronounced poor peripheral response in women, has been found in several studies [1,15], Fos ter et al [1] reported that aged women had an extremely poor sweat rate after stimulation and many were nonre sponders.…”

“…The abnorm al concentration of sodium in cystic fibrosis is believed to be the result of an impaired reabsorption of electrolytes in the duct portion of the gland. Increased sweat osmolality has also been reported in patients with Down's syndrome [4]. A high proportion Accepted: August 26,1992 of these patients will develop a dementia-like state later in life.…”