Sweating it out: How physical activity can combat high genetic risk for nonalcoholic fatty liver disease

Stine, Jonathan G.; Romeo, Stefano

doi:10.1111/liv.15642

Cited by 2 publications

(1 citation statement)

References 20 publications

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“…The relationship between exercise training and genetic risk for MASLD remains one of much interest 36 . Multiple recent reports suggest that moderate‐to‐high amounts of total physical activity (exercise is a subtype of physical activity that is planned, structured and repetitive and performed with a goal in mind 37 ) decrease the risk of incident MASLD 38–41 .…”

Section: Discussionmentioning

confidence: 99%

Exercise training improves serum biomarkers of liver fibroinflammation in patients with metabolic dysfunction‐associated steatohepatitis

Harris,

Smith,

Hummer

et al. 2023

Liver International

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Background and AimsExercise training is recommended for all patients with metabolic dysfunction‐associated steatotic liver disease and may reverse liver fibrosis. Whether exercise training improves liver fibrosis without body weight loss remains controversial. We further investigated this relationship using serum biomarkers of liver fibroinflammation in a post hoc analysis of an exercise trial where patients did not lose significant body weight.MethodsIn the NASHFit trial, patients with metabolic dysfunction‐associated steatohepatitis were randomized to receive either moderate‐intensity aerobic exercise training or standard clinical care for 20 weeks. Mediterranean‐informed dietary counselling was provided to each group. Change in serum biomarkers was measured and compared between the two groups.ResultsExercise training led to improvement in serum biomarkers of liver fibroinflammation, including (1) ≥17 IU/L reduction in alanine aminotransferase (ALT) in 53% of individuals in the exercise training group compared to 13% in the standard clinical care group (p < 0.001; mean reduction 24% vs. 10% respectively) and (2) improvement in CK18 (−61 vs. +71 ng/mL, p = 0.040). ALT improvement ≥17 IU/L was correlated with ≥30% relative reduction in magnetic resonance imaging‐measured liver fat and PNPLA3 genotype.ConclusionExercise training improves multiple serum biomarkers of liver fibroinflammation at clinically significant thresholds of response without body weight loss. This study provides further evidence that exercise training should be viewed as a weight‐neutral intervention for which response to intervention can be readily monitored with widely available non‐invasive biomarkers that can be applied at the population level.

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Section: Discussionmentioning

confidence: 99%

Exercise training improves serum biomarkers of liver fibroinflammation in patients with metabolic dysfunction‐associated steatohepatitis

Harris,

Smith,

Hummer

et al. 2023

Liver International

Self Cite

View full text Add to dashboard Cite

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The Role of Exercise in Steatotic Liver Diseases: An Updated Perspective

Alabdul Razzak,

Fares,

Stine

et al. 2024

Liver International

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BackgroundThe increasing prevalence of metabolic dysfunction‐associated steatotic liver disease (MASLD), formerly known as non‐alcoholic fatty liver disease (NAFLD), parallels the rise in sedentary lifestyles. MASLD is the most common form of steatotic liver disease (SLD), which represents the umbrella beneath which the vast majority of chronic liver diseases fall, including alcohol‐related liver disease and their overlap. These conditions are the leading contributors to chronic liver disease, significantly impacting global morbidity and mortality. Despite the emergence of new pharmacotherapies, exercise represents the foundation of MASLD treatment.ObjectiveThis review aims to provide an updated perspective on the role of exercise in the management of SLD, highlight its molecular and clinical benefits, and explore its benefits and safety in the stage of cirrhosis.MethodsEvidence from pre‐clinical and clinical studies was reviewed to evaluate the impact of exercise on SLD (mainly MASLD), advanced chronic liver disease stages, and its relevance in the context of evolving therapies such as Resmetirom and incretin‐based anti‐obesity medications.ConclusionExercise remains a cornerstone intervention in the management of MASLD, with suggested benefits even for patients who have progressed to cirrhosis. Personalized exercise regimens should be prioritized for all patients, including those receiving pharmacotherapy. Further research is needed to refine exercise protocols and investigate their impact on histologic and clinical outcomes, as well as their potential synergistic effects with emerging treatments.

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Sweating it out: How physical activity can combat high genetic risk for nonalcoholic fatty liver disease

Cited by 2 publications

References 20 publications

Exercise training improves serum biomarkers of liver fibroinflammation in patients with metabolic dysfunction‐associated steatohepatitis

Exercise training improves serum biomarkers of liver fibroinflammation in patients with metabolic dysfunction‐associated steatohepatitis

The Role of Exercise in Steatotic Liver Diseases: An Updated Perspective

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