Sweep visually evoked potentials and visual findings in children with West syndrome

Dotto, Patrícia de Freitas; Cavascan, Nívea Nunes; Berezovsky, Adriana; Sacai, Paula Yuri; Rocha, Daniel; Pereira, Josenilson Martins; Salomão, Solange Rios

doi:10.1016/j.ejpn.2013.11.008

Cited by 11 publications

(10 citation statements)

References 30 publications

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“…Poorer-than-normal VEP SF limits (''normal'' defined by 50 healthy, age-matched subjects) were found in 26 of 37 (70%) children aged 6-48 months with CP but without ophthalmological complaints and with normal fundi, and were more common in children with more severe motor impairment [200], as described elsewhere [197]. Poorerthan-normal VEP SF limits were also found in 29/30 children (6-108 months) with West syndrome [201].…”

Section: Amblyopiamentioning

confidence: 73%

VEP estimation of visual acuity: a systematic review

et al. 2020

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Purpose Visual evoked potentials (VEPs) can be used to measure visual resolution via a spatial frequency (SF) limit as an objective estimate of visual acuity. The aim of this systematic review is to collate descriptions of the VEP SF limit in humans, healthy and disordered, and to assess how accurately and precisely VEP SF limits reflect visual acuity. Methods The protocol methodology followed the PRISMA statement. Multiple databases were searched using ''VEP'' and ''acuity'' and associated terms, plus hand search: titles, abstracts or full text were reviewed for eligibility. Data extracted included VEP SF limits, stimulus protocols, VEP recording and analysis techniques and correspondence with behavioural acuity for normally sighted healthy adults, typically developing infants and children, healthy adults with artificially degraded vision and patients with ophthalmic or neurological conditions. Results A total of 155 studies are included. Commonly used stimulus, recording and analysis techniques are summarised. Average healthy adult VEP SF limits vary from 15 to 40 cpd, depend on stimulus, recording and analysis techniques and are often, but not always, poorer than behavioural acuity measured either psychophysically with an identical stimulus or with a clinical acuity test. The difference between VEP SF limit and behavioural acuity is variable and strongly dependent on the VEP stimulus and choice of acuity test. VEP SF limits mature rapidly, from 1.5 to 9 cpd by the end of the first month of life to 12-20 cpd

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Section: Amblyopiamentioning

confidence: 73%

VEP estimation of visual acuity: a systematic review

et al. 2020

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“…For instance, the use of visually evoked responses has been suggested as a relatively common quantitative method to directly compare cortical function in RTT patients and mouse models carrying mecp2 mutations ( 11 , 12 ). VEPs have also been used to reveal alterations in West Syndrome patients, EIEE1 (OMIM ref: #308350), and in EIEE3 (OMIM ref: #609304), supporting the translational and clinical applicability of this technique even in presence of seizures or hyperexcitability ( 29 , 30 ). Our results suggest that monitoring deficits in cortical visual function could also be applied to cdkl5 syndrome.…”

Section: Discussionmentioning

confidence: 87%

Searching for biomarkers of CDKL5 disorder: early-onset visual impairment in CDKL5 mutant mice

Mazziotti

Lupori

Sagona

et al. 2017

Human Molecular Genetics

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CDKL5 disorder is a neurodevelopmental disorder still without a cure. Murine models of CDKL5 disorder have been recently generated raising the possibility of preclinical testing of treatments. However, unbiased, quantitative biomarkers of high translational value to monitor brain function are still missing. Moreover, the analysis of treatment is hindered by the challenge of repeatedly and non-invasively testing neuronal function. We analyzed the development of visual responses in a mouse model of CDKL5 disorder to introduce visually evoked responses as a quantitative method to assess cortical circuit function. Cortical visual responses were assessed in CDKL5 null male mice, heterozygous females, and their respective control wild-type littermates by repeated transcranial optical imaging from P27 until P32. No difference between wild-type and mutant mice was present at P25-P26 whereas defective responses appeared from P27-P28 both in heterozygous and homozygous CDKL5 mutant mice. These results were confirmed by visually evoked potentials (VEPs) recorded from the visual cortex of a different cohort. The previously imaged mice were also analyzed at P60–80 using VEPs, revealing a persistent reduction of response amplitude, reduced visual acuity and defective contrast function. The level of adult impairment was significantly correlated with the reduction in visual responses observed during development. Support vector machine showed that multi-dimensional visual assessment can be used to automatically classify mutant and wt mice with high reliability. Thus, monitoring visual responses represents a promising biomarker for preclinical and clinical studies on CDKL5 disorder.

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“…Therefore, in patients who present partial vision loss, with fVEP test, it gains importance that how much they can see, but not whether they can see. In this sense, the pVEP test gains value [9]. There are several studies in the literature about the use of the pVEP test in objective determination of VA. To the best of our knowledge, the first study was conducted by Halliday [11].…”

Section: Discussionmentioning

confidence: 99%

“…In addition, the patient should not look at the fixation point in a pensive manner, called de-accommodation. With deaccommodation, normal individuals can make pVEP responses completely abnormal [9].…”

Section: Discussionmentioning

confidence: 99%

“…Until now, a number of tests for the measurement of VA have been developed. In the ophthalmology practice, electrophysiological tests can be used to measure the VA in infants, in non-cooperative cases, and in cases where the refraction is unable to be assessed due to media opacity and in the functional visual loss [1][2][3][4][5][6][7][8][9]. In addition, electrophysiological tests are the main tools of objective measurement of the vision in medico-legal conditions for clinicians [10].…”

Section: Introductionmentioning

confidence: 99%

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Pattern and Sweep Visual Evoked Potential in the Objective Determination of Visual Acuity

Hamurcu

2018

Preprint

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Background: To investigate the effects of pattern visual evoked potential (pVEP) and sweep visual evoked potential (sVEP) on the accurate visual acuity (VA) measurement in adults. Methods: Medical files of 282 eyes of 141 patients who underwent VA measurement in our electrophysiology laboratory and did not undergo simulation were retrospectively analyzed. The VA was measured using the Snellen chart. Only those with a VA of higher than 1/10 on the Snellen chart were included in the study. The VA was assessed and reported by the pVEP (VA-pVEP) and sVEP test (VA-sVEP). The correlation analysis was performed using the Pearson correlation analysis. Results: Of 141 patients, 92 were males and 49 were females with a mean age of 37.7±18.4 years. There was a strong positive correlation between the VA values obtained from both eyes by pVEP (VA-pVEP) (r=0.858, p<0.001). There was a weak positive correlation (r=0.267, p<0.001) between the VA measured by the Snellen chart and the VA measured by the sVEP (VA-sVEP). A weak positive correlation was found for the VA-pVEP and VA-sVEP (r=0.313, p<0.001). Conclusions: For the measurement of the degree of the VA, it seems reasonable to use pVEP initially, while sVEP should be used in cases with short attention span and those who are non-cooperative and in infants.

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Sweep visually evoked potentials and visual findings in children with West syndrome

Cited by 11 publications

References 30 publications

VEP estimation of visual acuity: a systematic review

VEP estimation of visual acuity: a systematic review

Searching for biomarkers of CDKL5 disorder: early-onset visual impairment in CDKL5 mutant mice

Pattern and Sweep Visual Evoked Potential in the Objective Determination of Visual Acuity

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