“Sweet” Architecture-Dependent Uptake of Glycocalyx-Mimicking Nanoparticles Based on Biodegradable Aliphatic Polyesters by Macrophages

Wu, Libin; Zhang, Yufei; Li, Zhen; Yang, Guang; Kochovski, Zdravko; Chen, Guosong; Jiang, Ming

doi:10.1021/jacs.7b07768

Cited by 67 publications

(78 citation statements)

References 69 publications

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“…More importantly, dextran‐based adjuvants could not only activate tumor‐specific CTL responses, but also inhibit myeloid‐derived suppressor cells (MDSCs) in tumor immune microenvironment . Many works indicate that binding between C‐type lectin receptors (CLRs) and carbohydrate ligands is important not only for the induction of T‐cell responses, but also for the inhibition of immunosuppressive microenvironment . Therefore, lymphoseek‐inspired vaccine should have advantages of promoting vaccine internalization, potentiating CD8 + T‐cell responses and reducing the immunosuppressive activity, and become a promising candidate for next‐generation cancer vaccine.…”

Section: Methodsmentioning

confidence: 99%

One‐Pot, Multicomponent Strategy for Designing Lymphoseek‐Inspired Hetero‐Glycoadjuvant@AuNPs

Liu

Wen

Shen

et al. 2019

Macromol. Rapid Commun.

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transported to draining lymph nodes. The second approach is based on the activation of antigen-presenting cells (APCs) to induce T cell. [9,10] Recently, inspired by the lymphoseek [11] (which is a mannose-conjugated, dextran-based LN imaging agent, acting as receptor-targeted radiotracer in breast cancer and melanoma patients), we have first developed LN-targeting adjuvant by conjugating toll-like receptor (TLR) [9] agonists, unmethylated Cytosinephosphate-Guanosine (CpG) to natural dextran. [12] Although dextran-functionalized adjuvant could not increase adjuvant internalization, they could distinctly enhance CD8 + T-cell responses, and improve cancer immunotherapy. [12] More importantly, dextran-based adjuvants could not only activate tumor-specific CTL responses, but also inhibit myeloid-derived suppressor cells (MDSCs) in tumor immune microenvironment. [13] Many works indicate that binding between C-type lectin receptors (CLRs) and carbohydrate ligands [14][15][16][17][18][19] is important not only for the induction of T-cell responses, but also for the inhibition of immunosuppressive microenvironment. [13] Therefore, lymphoseek-inspired vaccine should have advantages of promoting vaccine internalization, potentiating CD8 + T-cell responses and reducing the immunosuppressive activity, and become a promising candidate for nextgeneration cancer vaccine.Much effort has been devoted to developing new methodologies for the design and preparation of multifunctional adjuvant, which is the most challenging work. To obtain bioactive adjuvant, simple and highly efficient reaction should be used to formulate adjuvant. To date, most of the works use "grafting to" method to generate target adjuvant. [20][21][22][23] Lynn et al. attached small-molecule TLR-7/8a agonists to hydrophilic polymers to form polymer-TLR-7/8a conjugates by "grafting to" strategy. [24] Recently, inspired by quinone chemistry, we have also introduced "thiol-quinone" reaction to attach thiolated CpG to NPs for fabricating pathogen-mimetic [25][26][27] adjuvants by the "grafting to" method. [28] Besides, few works employ multicomponent strategy to design adjuvants. It is well known that onepot multicomponent strategy offers obvious advantages of simplicity and high efficiency over traditional chemical reactions. Moreover, one-pot strategy is more convenient to obtain high concentration adjuvants. Herein, we report a novel multicomponent strategy to develop lymphoseek-inspired adjuvants in one-pot. First, photo-induced reversible addition-fragmentation Glycoadjuvants Searching for vaccines (antigen and adjuvant) with easy preparation and strong T-cell response are crucial for antitumor immunity. In this work, to design lymphoseek-inspired vaccine possessing the abilities of promoting vaccine internalization and enhancing CD8 + T-cell responses, a simple multicomponent strategy is successfully utilized to fabricate lymph node and dendritic cell dual-targeting glycoadjuvant@AuNPs in one pot, where three different components, catechol-containing glycopol...

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Section: Methodsmentioning

confidence: 99%

One‐Pot, Multicomponent Strategy for Designing Lymphoseek‐Inspired Hetero‐Glycoadjuvant@AuNPs

Liu

Wen

Shen

et al. 2019

Macromol. Rapid Commun.

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“…Previous studies demonstrated the modulation ability of the glycocalyx‐mimicking NPs (GNPs) on M2‐like TAMs by reduction of suppressive functions . To develop the nanostructures with better stability and functionality, mimicking glycocalyx, an important cell surface structure of polymeric sugar layer, has become a promising strategy for the rational design of targeted nanocarriers, since the architecture of glycocalyx has been found to greatly influence the sugar‐receptor interaction, as well as uptake by macrophages or cancer cells . In this regard, Zhang et al incorporated αPD‐L1 mAb into the self‐assembled mannose‐functionalized GNPs targeting TME to restore immune functions in the TME by promoting the reversion of TAMs, and thus enhance the αPD‐L1 therapeutic effect by decreasing tumor resistance (Figure ) .…”

Section: Mannose‐based Nanomaterials In Biomedical Applicationsmentioning

confidence: 99%

Mannose‐Functionalized Nanoscaffolds for Targeted Delivery in Biomedical Applications

Wei

Seeberger

et al. 2018

Chemistry An Asian Journal

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Targeted drug delivery by nanomaterials has been extensively investigated as an effective strategy to surmount obstacles in the conventional treatment of cancer and infectious diseases, such as systemic toxicity, low drug efficacy, and drug resistance. Mannose‐binding C‐type lectins, which primarily include mannose receptor (MR, CD206) and dendritic cell‐specific intercellular adhesion molecule‐3‐grabbing non‐integrin (DC‐SIGN), are highly expressed on various cancer cells, endothelial cells, macrophages, and dendritic cells (DCs), which make them attractive targets for therapeutic effect. Mannosylated nanomaterials hold great potential in cancer and infection treatment on account of their direct therapeutic effect on targeted cells, modulation of the tumor microenvironment, and stimulation of immune response through antigen presentation. This review presents the recent advances in mannose‐based targeted delivery nanoplatforms incorporated with different therapies in the biomedical field.

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“…It highlighted a strategy for engineering a biosourced polysaccharide with surface moieties that exhibited strong multivalent interactions with lectins, and targeted interaction with prostate cancer cells. Wu et al (2017) explored the architectural effect of the glyconanoparticle corona on glyconanoparticle macrophage endocytosis and lectin-binding ability. Nanoparticles with a mixed shell showed a higher efficiency in cellular uptake and lectin-binding than those with a single sugar component.…”

Section: Magnetic Glyconanoparticlesmentioning

confidence: 99%

The glyconanoparticle as carrier for drug delivery

Zhang

Huang

2018

Drug Delivery

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The glyconanoparticle (GlycoNP) has multiple effects and has important applications in drug delivery and bioimaging. It not only has the advantages of nano drug delivery system but also utilizes the characteristics of multivalent interaction of sugar, which greatly improves the targeting of drug delivery. Herein, the application of GlycoNP in drug delivery was analyzed and discussed, the solution to its problem was proposed, and its prospects were forecasted. ARTICLE HISTORY

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“Sweet” Architecture-Dependent Uptake of Glycocalyx-Mimicking Nanoparticles Based on Biodegradable Aliphatic Polyesters by Macrophages

Cited by 67 publications

References 69 publications

One‐Pot, Multicomponent Strategy for Designing Lymphoseek‐Inspired Hetero‐Glycoadjuvant@AuNPs

One‐Pot, Multicomponent Strategy for Designing Lymphoseek‐Inspired Hetero‐Glycoadjuvant@AuNPs

Mannose‐Functionalized Nanoscaffolds for Targeted Delivery in Biomedical Applications

The glyconanoparticle as carrier for drug delivery

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