Sweet Poisons: Honeys Contaminated with Glycosides of the Neurotoxin Tutin

Larsen, Lesley; Joyce, Nigel I.; Sansom, Catherine E.; Cooney, Janine M.; Jensen, Dwayne J.; Perry, Nigel B.

doi:10.1021/acs.jnatprod.5b00241

Cited by 29 publications

(27 citation statements)

References 19 publications

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“…These oxygenated sesquiterpene picrotoxanes, targeting GABAergic and glycinergic receptors, are ingested by honeybees collecting honeydew produced by passionvine hoppers ( Scolypopa australis ) feeding on sap of the poisonous shrub tutu ( Coriaria spp.) (Fields et al, 2014; Larsen et al, 2015). Other plant secondary metabolites, which are found in honey and could induce deleterious effects to humans, include hyoscyamine and hyoscine from Solanaceae, saponins from Sapindaceae, strychnine and gelsemine from Gelsemiaceae, oleandrin and oleandrigenin from Apocynaceae (Islam et al, 2014).…”

Section: Honeymentioning

confidence: 99%

Therapeutic Properties of Bioactive Compounds from Different Honeybee Products

et al. 2017

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Honeybees produce honey, royal jelly, propolis, bee venom, bee pollen, and beeswax, which potentially benefit to humans due to the bioactives in them. Clinical standardization of these products is hindered by chemical variability depending on honeybee and botanical sources, but different molecules have been isolated and pharmacologically characterized. Major honey bioactives include phenolics, methylglyoxal, royal jelly proteins (MRJPs), and oligosaccharides. In royal jelly there are antimicrobial jelleins and royalisin peptides, MRJPs, and hydroxy-decenoic acid derivatives, notably 10-hydroxy-2-decenoic acid (10-HDA), with antimicrobial, anti-inflammatory, immunomodulatory, neuromodulatory, metabolic syndrome preventing, and anti-aging activities. Propolis contains caffeic acid phenethyl ester and artepillin C, specific of Brazilian propolis, with antiviral, immunomodulatory, anti-inflammatory and anticancer effects. Bee venom consists of toxic peptides like pain-inducing melittin, SK channel blocking apamin, and allergenic phospholipase A2. Bee pollen is vitaminic, contains antioxidant and anti-inflammatory plant phenolics, as well as antiatherosclerotic, antidiabetic, and hypoglycemic flavonoids, unsaturated fatty acids, and sterols. Beeswax is widely used in cosmetics and makeup. Given the importance of drug discovery from natural sources, this review is aimed at providing an exhaustive screening of the bioactive compounds detected in honeybee products and of their curative or adverse biological effects.

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Section: Honeymentioning

confidence: 99%

Therapeutic Properties of Bioactive Compounds from Different Honeybee Products

et al. 2017

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“…The amount of minerals in honey varies from 0.2 to 0.4, which reflects the number of soil minerals in honey nectar plants. Approximately one-third of honey is consisted of potassium [19].…”

Section: Resultsmentioning

confidence: 99%

The Therapeutic Effects of Bioactive Compounds in Honeybee Products

Hesami

Haghighian

2019

J. Qazvin Univ. Med. Sci.

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Honey, royal jelly, propolis, and bee pollen are potentially beneficial to humans due to their bioactive agents. Different molecules of these honeybee products have been extracted and pharmacologically characterized. Phenolic acid, Major Royal Jelly Proteins (MRJPs), and oligosaccharides are major bioactive substances of these products. Propolis, especially Brazilian type, contains caffeic acid phenethyl ester and artepillin C, with immunomodulatory, anti-inflammatory, and anticarcinogenic effects. Bee pollen has antioxidant and anti-inflammatory properties due to vitamins and plant phenols. Additionally, flavonoids, unsaturated fatty acids, and sterols contribute in antiatherosclerotic, antidiabetic, and hypoglycemic properties of bee pollen. In the royal jelly, there are MRJPs and hydroxy-decenoic acid derivatives, especially 10-Hydroxy-2-Decanoic Acid (10-HDA). This review study was conducted in 2016-2017 with the aim of investigating the therapeutic effects of honeybee products by searching the databases of PubMed, Scopus, ScienceDirect, IranMedex and Google Scholar using the keywords "honey, propolis, royal jelly, bee pollen, anti-inflammatory, and antioxidant". In this study, we observed that the anti-inflammatory activity, immunomodulation, nerve regulation, and the prevention of metabolic syndrome are attributed to these factors. Given the importance of discovering and access to herbal medicines, this review provided a comprehensive overview of the bioactive compounds detected in the honeybee products as well as the therapeutic effects and biological side effects of them.

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“…However, it was also cited as a low-proportion forage plant for pig feed. It contains neurotoxic sesquiterpene lactone compounds, such as coriamyrtin ( De Haro et al., 2005 ) and tutin ( Wei et al., 1998 ; Zhao et al., 2012 ; Larsen et al., 2015 ; Watkins et al., 2018 ; J. Yang et al., 2020 ). C. nepalensis is therefore not recommended for use as a forage plant.…”

Section: Discussionmentioning

confidence: 99%

An ethnobotanical study of forage plants in Zhuxi County in the Qinba mountainous area of central China

Yang

Luo

Gan³

et al. 2021

Plant Diversity

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In the Qinba mountainous area of Central China, pig farming has a significant impact on the growth of the rural economy and has substantially increased farmer incomes. Traditional knowledge plays an important role in the selection of forage plant species for pig farming by local people. This study aimed to identify the forage plants used for pig feeding and to catalog indigenous knowledge regarding their use. During 2016 and 2017, ethnobotanical surveys and inventories were conducted in Zhuxi County, Hubei Province, China. Data were collected using semi-structured interviews, key informant reports, free listings, guided field walks, and participatory observations with 77 households in 16 villages in 13 towns/townships. The obtained data were analyzed using a relative frequency citation (RFC) index. Overall, 145 wild forage plants from 91 genera and 31 families were recorded. The most cited families were Asteraceae, Polygonaceae, Urticaceae, Amaranthaceae, Fabaceae, Cruciferae, Caryophyllaceae, and Lamiaceae. Whole plants (75.9%) and tender leaves (12.4%) were the most frequently used parts of the plants. Most of the forage plants were herbaceous (88.9%). Almost all forage plants could be collected throughout the year (62.7%). Raw and cooked were the two main preparation methods. The most frequently cited species were Taraxacum mongolicum , Bidens pilosa , Sonchus oleraceus , Pilea verrucosa , and Pilea pumila var. obtusifolia . A total of 14 species were identified as the top forage plants in Zhuxi County based on their RFC values (RFC value greater than 0.5). Local people possess rich traditional knowledge about the utilization and management of forage plants for pig feeding. However, the maintenance of this traditional knowledge may be seriously threatened by changes in pig feeding modes and the lack of successors. Appropriate strategies and action plans have been suggested for the conservation of traditional knowledge associated with biodiversity and the sustainable use of forage species resources. These include 1) taking targeted measures to protect forage resources and associated traditional knowledge; 2) strengthening research on the forage plants with the highest RFC values for nutritional value, digestibility, other functions, and ecological status; and 3) enhancing the identification of poisonous forage plants.

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Sweet Poisons: Honeys Contaminated with Glycosides of the Neurotoxin Tutin

Cited by 29 publications

References 19 publications

Therapeutic Properties of Bioactive Compounds from Different Honeybee Products

Therapeutic Properties of Bioactive Compounds from Different Honeybee Products

The Therapeutic Effects of Bioactive Compounds in Honeybee Products

An ethnobotanical study of forage plants in Zhuxi County in the Qinba mountainous area of central China

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