Sweet Potato β-Carotene Bioefficacy Is Enhanced by Dietary Fat and Not Reduced by Soluble Fiber Intake in Mongolian Gerbils

Mills, Jordan P.; Tumuhimbise, Gaston A.; Jamil, Kazi M.; Thakkar, Sagar K.; Failla, Mark L.; Tanumihardjo, Sherry A.

doi:10.3945/jn.108.098947

Cited by 47 publications

(47 citation statements)

References 39 publications

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“…The bioaccessibility of β‐carotene in orange‐fleshed sweet potato is highly variable, with estimates ranging from 0.6% to 73% . As noted in the gerbil study, differences in the fat content of the food products or between the different assays were partially responsible for this variation.…”

Section: Staple Food Crops Biofortified With Provitamin a Carotenoidsmentioning

confidence: 62%

Bioavailability of iron, zinc, and provitamin A carotenoids in biofortified staple crops

et al. 2014

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International research efforts, including those funded by HarvestPlus, a Challenge Program of the Consultative Group on International Agricultural Research (CGIAR), are focusing on conventional plant breeding to biofortify staple crops such as maize, rice, cassava, beans, wheat, sweet potatoes, and pearl millet to increase the concentrations of micronutrients that are commonly deficient in specific population groups of developing countries. The bioavailability of micronutrients in unfortified staple crops in developing regions is typically low, which raises questions about the efficacy of these crops to improve population micronutrient status. This review of recent studies of biofortified crops aims to assess the micronutrient bioavailability of biofortified staple crops in order to derive lessons that may help direct plant breeding and to infer the potential efficacy of food-based nutrition interventions. Although reducing the amounts of antinutrients and the conduction of food processing generally increases the bioavailability of micronutrients, antinutrients still possess important benefits, and food processing results in micronutrient loss. In general, biofortified foods with relatively higher micronutrient density have higher total absorption rates than nonbiofortified varieties. Thus, evidence supports the focus on efforts to breed plants with increased micronutrient concentrations in order to decrease the influence of inhibitors and to offset losses from processing.

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Section: Staple Food Crops Biofortified With Provitamin a Carotenoidsmentioning

confidence: 62%

Bioavailability of iron, zinc, and provitamin A carotenoids in biofortified staple crops

et al. 2014

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“…Although only focusing on partial aspects of human digestion, such as release of carotenoids from food matrix, solubility and emulsion into mixed micelles, it has been shown that results from carotenoid bioaccessibility experiments seem to be well correlated with data obtained from human studies (Reboul et al, 2006). Thus, this in vitro model has aided in understanding the impact of various dietary and host-related factors on carotenoid availability, including gastric and intestinal conditions (Garrett et al, 1999;Wright, Pietrangelo, & MacNaughton, 2008), the food matrix (Hedren et al, 2002), the impact of dietary fibre (Mills et al, 2009) and the type of ingested fat (Huo, Ferruzzi, Schwartz, & Failla, 2007). However, many potential factors impacting carotenoid bioaccessibility have not been thoroughly and systematically explored, including mineral concentrations.…”

Section: Introductionmentioning

confidence: 86%

Dietary and host-related factors influencing carotenoid bioaccessibility from spinach (Spinacia oleracea)

Biehler

Kaulmann²,

Hoffmann³

et al. 2011

Food Chemistry

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“…In animals fed graded amounts of fat, the bioefficacy of sweet potato β-carotene was enhanced with the highest fat amount (155). …”

Section: Biology Of Vitamin Amentioning

confidence: 99%

Biomarkers of Nutrition for Development (BOND)—Vitamin A Review

Tanumihardjo

Russell

Stephensen

et al. 2016

The Journal of Nutrition

366

414

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The Biomarkers of Nutrition for Development (BOND) project is designed to provide evidence-informed advice to anyone with an interest in the role of nutrition in health. The BOND program provides information with regard to selection, use, and interpretation of biomarkers of nutrient exposure, status, function, and effect, which will be especially useful for readers who want to assess nutrient status. To accomplish this objective, expert panels are recruited to evaluate the literature and to draft comprehensive reports on the current state of the art with regard to specific nutrient biology and available biomarkers for assessing nutritional status at the individual and population levels. Phase I of the BOND project includes the evaluation of biomarkers for 6 nutrients: iodine, folate, zinc, iron, vitamin A, and vitamin B-12. This review of vitamin A is the current article in this series. Although the vitamin was discovered >100 y ago, vitamin A status assessment is not trivial. Serum retinol concentrations are under homeostatic control due in part to vitamin A’s use in the body for growth and cellular differentiation and because of its toxic properties at high concentrations. Furthermore, serum retinol concentrations are depressed during infection and inflammation because retinol-binding protein (RBP) is a negative acute-phase reactant, which makes status assessment challenging. Thus, this review describes the clinical and functional indicators related to eye health and biochemical biomarkers of vitamin A status (i.e., serum retinol, RBP, breast-milk retinol, dose-response tests, isotope dilution methodology, and serum retinyl esters). These biomarkers are then related to liver vitamin A concentrations, which are usually considered the gold standard for vitamin A status. With regard to biomarkers, future research questions and gaps in our current understanding as well as limitations of the methods are described.

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Sweet Potato β-Carotene Bioefficacy Is Enhanced by Dietary Fat and Not Reduced by Soluble Fiber Intake in Mongolian Gerbils

Cited by 47 publications

References 39 publications

Bioavailability of iron, zinc, and provitamin A carotenoids in biofortified staple crops

Bioavailability of iron, zinc, and provitamin A carotenoids in biofortified staple crops

Dietary and host-related factors influencing carotenoid bioaccessibility from spinach (Spinacia oleracea)

Biomarkers of Nutrition for Development (BOND)—Vitamin A Review

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