1999
DOI: 10.1542/peds.104.5.1142
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Sweet's Syndrome as an Initial Manifestation of Pediatric Human Immunodeficiency Virus Infection

Abstract: We report a 3-month-old infant in whom Sweet's syndrome was a presenting manifestation of pediatric human immunodeficiency virus infection. Although rare in children, Sweet's syndrome may be associated with certain infections and malignancies. The diagnosis of Sweet's syndrome in a child should always prompt a thorough evaluation to assess for an associated systemic disease.

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Cited by 43 publications
(26 citation statements)
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“…There was 1 case of immunodeficiency secondary to HIV infection. 6 Finally, 5 children had presumed genetic causes, 2 of whom were brothers with limited reported extracutaneous symptoms, although 1 of these children died at age 4 years from pulmonary hypertension. 27 Three other possible genetic cases came from an initial report of 4 children with what was presented as a new, probably monogenic condition of chronic atypical neutrophilic dermatosis with lipodystrophy and elevated temperature (CANDLE) syndrome 28 , which is caused by mutations in the PSMB8 gene.…”
Section: Results Of the Literature Reviewmentioning
confidence: 99%
“…There was 1 case of immunodeficiency secondary to HIV infection. 6 Finally, 5 children had presumed genetic causes, 2 of whom were brothers with limited reported extracutaneous symptoms, although 1 of these children died at age 4 years from pulmonary hypertension. 27 Three other possible genetic cases came from an initial report of 4 children with what was presented as a new, probably monogenic condition of chronic atypical neutrophilic dermatosis with lipodystrophy and elevated temperature (CANDLE) syndrome 28 , which is caused by mutations in the PSMB8 gene.…”
Section: Results Of the Literature Reviewmentioning
confidence: 99%
“…However, the lesions may persist for weeks to months [10,23,254,355]. Successful management of the cancer occasionally results in clearing of the related dermatosis in patients with malignancy-associated Sweet's syndrome [13,15,23].…”
Section: Prognosismentioning
confidence: 99%
“…Extracutaneous manifestations of Sweet's syndrome can affect not only the mucosa of the eyes and mouth, but also the bone, central nervous system, kidneys, intestines, liver, heart, bronchi and lungs, muscles, and spleen (Table 3). 6,7,9,11,16,18,24,25,28,36,52,68,69,75,85,97–129 Involvement of the oral mucosa most commonly presents as ulcers in Sweet's syndrome patients with hematologic disorders 14,18 ,69,75 ,115,127 . Similar to extracutaneous manifestations of Sweet's syndrome at other sites, the oral lesions typically resolve after the initiation of treatment with systemic corticosteroids.…”
Section: Clinical Characteristicsmentioning
confidence: 99%