Sweet’s Syndrome Associated with <i>Yersinia enterocolitica</i> Infection

Abstract

Acute febrile neutrophilic dermatosis (Sweet’s syndrome) was diagnosed on the basis of typical clinical and histological features in a 45-year-old woman. Gastrointestinal symptoms had preceded the dermatosis, and an intestinal infection with Yersinia enterocolitica could be proven by culture and serology. This first report on an association between Yersinia infection and Sweet’s syndrome widens the spectrum of both infectious diseases possibly inducing acute febrile neutrophilic dermatosis and dermatological manifestations of yersiniosis.

Sweet's syndrome – a comprehensive review of an acute febrile neutrophilic dermatosis

“…The lesions often mimic erythema nodosum when they are located on the legs [170]. Even in a patient whose Sweet's syndrome has previously been biopsy-confirmed, tissue evaluation of one or more new dermal nodules may be necessary to establish the correct diagnosis since Sweet's syndrome can present concurrently (Figures 6 and 7) [21,125,187-189] or sequentially [170] with erythema nodosum [1,2,4,17,21,187,190,403]. …”

“…Since most patients with classic Sweet's syndrome have a febrile upper respiratory tract infection or tonsillitis that precedes their skin lesions by 1 to 3 weeks, a bacterial infection may have a causative role. Also, the manifestations of Sweet's syndrome improve with systemic antibiotics in some of the patients with dermatosis-associated culture-confirmed and serology-confirmed Yersinia enterolitica intestinal infection [2,77,125-127]. …”

Acute promyelocytic leukemia‐associated Sweet's syndrome mimicking an axillary abscess: A case report with review of literature

“…A case of culture-confirmed and serology-confirmed Yersinia enterocolitica intestinal infection associated SS improved after systemic antibiotics. 15 (2) Hypersensitivity reaction (response to corticosteroid treatment). (3) Overproduction and inappropriate regulation of inflammatory cytokines.…”

Cutaneous Aseptic Neutrophilic Abscesses and <i>Yersinia</i><i>enterocolitica</i> Infection in a Case Subsequently Diagnosed as Crohn’s Disease

“…The association between Yersinia infection and ND is rare and has only been documented with Sweet’s syndrome [14, 15]. Furthermore, the cold-chain hypothesis suggests that bacteria such as Yersinia species may contribute to the development of CD and have been identified in CD lesions [16].…”