Sweet's syndrome with pulmonary involvement: Case report and literature review

Fernández-Bussy, Sebastián; Labarca, Gonzalo; Cabello, Francisca; Cabello, Hernán; Folch, Erik; Majid, A.

doi:10.1016/j.rmcr.2012.08.004

Cited by 19 publications

(18 citation statements)

References 27 publications

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“…Chest X-ray usually shows diffuse pulmonary infiltrates, and unilateral or bilateral interstitial infiltrates can be confirmed on chest CT. In some cases, pulmonary opacities and pleural effusions have also been described 6 7. The majority of cases show prompt improvement following oral or intravenous corticosteroid therapy.…”

Section: Discussionmentioning

confidence: 99%

“…Pulmonary involvement in Sweet’s syndrome manifests as a neutrophilic alveolitis with corticosteroid-responsive culture-negative pulmonary infiltrates 6. A recent review article identified 34 previously reported cases of Sweet’s syndrome with pulmonary involvement 7. Cutaneous and pulmonary symptoms are usually concomitant, although occasionally skin lesions can precede lung involvement by months or years.…”

Section: Discussionmentioning

confidence: 99%

“…The majority of cases show prompt improvement following oral or intravenous corticosteroid therapy. Other immunosuppressant therapy with colchicine or dapsone has been described in six cases 7. Sweet’s syndrome with pulmonary involvement can progress to fatal respiratory failure and there are five reported cases of death from acute respiratory distress syndrome 8–12…”

Section: Discussionmentioning

confidence: 99%

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Sweet’s syndrome with pulmonary involvement

et al. 2019

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Sweet’s syndrome is an acute febrile neutrophilic dermatosis with classical clinical features. Systemic manifestations in Sweet’s syndrome including fever, arthralgia, myalgia and ocular involvement are common. Pulmonary involvement is a rare manifestation that has been reported previously in 34 cases and can be fatal if left untreated. We report a striking case of Sweet’s syndrome with respiratory failure secondary to bilateral pulmonary interstitial infiltrates, which rapidly responded to intravenous corticosteroid therapy. This case is an important reminder of the systemic manifestations of Sweet’s syndrome and highlights the value of collaboration between different medical specialities to optimise patient management and outcomes.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Sweet’s syndrome with pulmonary involvement

et al. 2019

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“…Sweet's rash preceded lung symptoms in 6 cases, while the other 5 of 11 patients complained of the respiratory condition first. Imaging work most frequently revealed interstitial lung opacities that can be unilateral [60–72] or bilateral [73–84] with or without pleural effusions and no site or lobe predilection [78, 85, 86]. A presenting scenario such as this can be easily confused with pneumonia especially when a biopsy from the lesions is not feasible in critically ill patients, those prone to bleeding or other high risk complications [72, 87].…”

Section: Neutrophilic Dermatosesmentioning

confidence: 99%

Neutrophilic Dermatoses and Their Implication in Pathophysiology of Asthma and Other Respiratory Comorbidities: A Narrative Review

Salem

Kimak

Conic

et al. 2019

BioMed Research International

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Neutrophilic dermatoses (ND) are a polymorphous group of noncontagious dermatological disorders that share the common histological feature of a sterile cutaneous infiltration of mature neutrophils. Clinical manifestations can vary from nodules, pustules, and bulla to erosions and ulcerations. The etiopathogenesis of neutrophilic dermatoses has continuously evolved. Accumulating genetic, clinical, and histological evidence point to NDs being classified in the spectrum of autoinflammatory conditions. However, unlike the monogenic autoinflammatory syndromes where a clear multiple change in the inflammasome structure/function is demonstrated, NDs display several proinflammatory abnormalities, mainly driven by IL-1, IL-17, and tumor necrosis factor-alpha (TNF-a). Additionally, because of the frequent association with extracutaneous manifestations where neutrophils seem to play a crucial role, it was plausible also to consider NDs as a cutaneous presentation of a systemic neutrophilic condition. Neutrophilic dermatoses are more frequently recognized in association with respiratory disorders than by chance alone. The combination of the two, particularly in the context of their overlapping immune responses mediated primarily by neutrophils, raises the likelihood of a common neutrophilic systemic disease or an aberrant innate immunity disorder. Associated respiratory conditions can serve as a trigger or may develop or be exacerbated secondary to the uncontrolled skin disorder. Physicians should be aware of the possible pulmonary comorbidities and apply this knowledge in the three steps of patients’ management, work-up, diagnosis, and treatment. In this review, we attempt to unravel the pathophysiological mechanisms of this association and also present some evidence for the role of targeted therapy in the treatment of both conditions.

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“…Sweet Syndrome (SS; also known as acute febrile neutrophilic dermatosis) is a systemic inflammatory disorder that is typically characterized by high fever, leukocytosis, and tender regions of erythema. 2 Although it carries a link to MDS, malignancy-associated SS is most often associated with acute myelogenous leukemia (AML), with a temporal pattern revolving around the onset and relapse of underlying disease. 3,4 In some cases of MDS, a transformation to acute leukemia can take place.…”

Section: Introductionmentioning

confidence: 99%

An Unlikely Rapid Transformation of Myelodysplastic Syndrome to Acute Leukemia: A Case Report

Pourmoussa

Kwan

2017

TPJ

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Two important factors stood out as representing an atypical presentation. First, this patient lacked any of the high-risk features of myelodysplastic syndrome that typically portend transformation. In addition, his progression to acute leukemia in 28 days from the time of diagnosis was far more rapid than the 274-day median previously described in the literature. We theorize that the presence of Sweet syndrome may have served as a predisposing factor to transformation. This finding may offer benefit to physicians to potentially better predict this outcome and pursue more aggressive treatment measures earlier in the course of the disease in such a setting.

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Sweet's syndrome with pulmonary involvement: Case report and literature review

Cited by 19 publications

References 27 publications

Sweet’s syndrome with pulmonary involvement

Sweet’s syndrome with pulmonary involvement

Neutrophilic Dermatoses and Their Implication in Pathophysiology of Asthma and Other Respiratory Comorbidities: A Narrative Review

An Unlikely Rapid Transformation of Myelodysplastic Syndrome to Acute Leukemia: A Case Report

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