Sweet's syndrome without granulocytosis

Abstract

Sweet's syndrome should be considered in the differential diagnosis when acute myeloid leukemic patients develop skin lesions and unexplained fevers regardless of the peripheral blood counts.

Síndrome de Sweet asociado a neoplasias

“…The absence of neutrophilia does not exclude this diagnosis since neutropenia can be evident due to the subjacent disease or the chemotherapy treatment these patients receive. 2,5,22,23 Additionally, G-CSF is one of the frequent causes of drug-related Sweet syndrome and this possibility must therefore be ruled out. 3 In immunosuppressed patients, the coexistence of fever, neutrophilia, and skin lesions requires the consideration, first of all, of the possibility of infectious conditions that should be excluded first, since this determines the subsequent treatment.…”

“…5 Although neutrophilic leukocytosis is one of the diagnostic criteria, it is absent in up to 50% of cases associated with neo- plasms, and does not, therefore, exclude the diagnosis. 2,5,7,22 Anemia and abnormal platelet count are frequent in oncohematologic disease patients, which coincides with the natural history of the underlying disease and chemotherapy treatment. Neutropenia can also be explained by what was previously mentioned, as was seen in cases # 1 and # 3.…”

Hyperfunction of neutrophils in a patient with BCR/ABL negative chronic myeloid leukemia

“…However, hyperresponsiveness of myeloid progenitor cells to G-CSF and enhanced neutrophil functions in the terminal phase, including fMLP-stimulated superoxide production and in vitro production of IL-8 might be strongly related to the pathogenesis of PAP as well as Sweet syndrome and be some clues to elucidate at least a part of BCR/ABL negative CML. 24 1998 CML (1) SS Pertusi et al 25 1996 CML (1) SS Kannan et al 26 1995 CML (1) SS Brodkin and Schwartz 27 1995 CML (1) SS Dieguez et al 28 1993 CML (1) SS Torri et al 29 1993 CML (1) SS Feliu et al 30 1992 CML (2) SS Sanchez-Yus and Palou 31 1992 CML (1) SS Gonzalez-Castro et al 32 1991 CML (1) SS Mijovic et al 33 1991 CML (1) SS Elovaara et al 34 1990 CML (1) SS Bello Lopez et al 35 1990 CML (1) SS Cohen and Kurzrock 36 1989 CML (1) SS Hatch et al 37 1989 CML (1) SS Rauh et al 38 1989 CML (1) SS Visani et al 39 1988 CML (1) SS Marcos Sanchez et al 40 1985 CML (1) SS Odeh 41 1981 CML (1) SS Chmel and Armstrong 42 1978 CML (1) SS Rodriguez-Luaces et al 43 1997 CML (1) PAP Cordonnier et al 3 1994 CML (4) PAP Ito et al 44 1994 CML (1) PAP Miyake et al 45 1992 CML (1) PAP Watanabe et al 46 1990 CML (1) PAP Magy et al 47 1985 CML (1) PAP Aymard et al 48 1984 CML (1) PAP Green et al 49 1980 CML (1) PAP Miyashita et al 50 1977 CML (1) PAP Yamamoto et al 51 1975 CML (1) PAP Nakamura et al 52 1988 Graves (1) SS CML: chronic myeloid leukemia; PAP: pulmonary alveolar proteinosis; SS: Sweet syndrome.…”

Granulocyte Colony Stimulating Factor Induced Sweet’s Syndrome Following Autologous Transplantation in a Child with Relapsed Acute Myeloblastic Leukemia

“…However, Sweet's syndrome reported in a few cases of AML during leukopenic and/or neutropenic period following chemotherapy [9]. Similarly, Sweet's syndrome developed during the leukopenic/neutropenic period shortly after the transplantation-conditioning regimen.…”