Sweet syndrome and erythema nodosum in a case of anal canal cancer during concomitant radiochemotherapy

Moreau, Estelle; Peiffert, D.; Schmutz, J.‐L.; Granel‐Brocard, F.; Bursztejn, Anne‐Claire

doi:10.1684/ejd.2019.3628

Cited by 4 publications

(4 citation statements)

References 10 publications

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“… 1 Literature review demonstrated 4 reported cases of malignancy-associated Sweet syndrome in the context of anal cancer or rectal adenocarcinoma ( Table I ). 5 , 6 , 7 , 8 We considered whether Sweet syndrome was due to malignancy or triggered by recent neoadjuvant chemoradiation.…”

Section: Discussionmentioning

confidence: 99%

Sweet syndrome in a patient with rectal adenocarcinoma and HIV following neoadjuvant chemoradiation

Wilkerson,

Bradley,

Lee

et al. 2024

JAAD Case Reports

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Section: Discussionmentioning

confidence: 99%

Sweet syndrome in a patient with rectal adenocarcinoma and HIV following neoadjuvant chemoradiation

Wilkerson,

Bradley,

Lee

et al. 2024

JAAD Case Reports

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“…Although rare, concurrent occurrence of Sweet's syndrome and erythema nodosum is described and may be associated with autoimmune disorders, certain malignancies, gastrointestinal disease. A case of a young male with a recent streptococcal infection was also described [9][10][11][12][13][14][15][16] . Case Report…”

Section: -74mentioning

confidence: 99%

“…Both are also reactive dermatoses with some similar clinical manifestations and histopathological findings, which could be successfully solved with corticosteroid therapy 3-5. Concurrent SS and EN are rare, but are described in the literature in connection with autoimmune or malignant diseases and also some respiratory, mostly streptococcal infections [9][10][11][12][13] .…”

Section: -74mentioning

confidence: 99%

“…We presumed that concurrent SS and EN in our patient was triggered with respiratory infection, but there is also possibility to be induced by antibiotic therapy. There is evidence in the literature that SS or EN are associated with some respiratory or gastrointestinal infections, including recent description of 29-year old Mexican who developed concurrent SS and EN possibly after the upper respiratory tract infection [9][10][11][12][13] . So far, there is no evidence in the literature that SS or EN could be induced by ibuprofen or paracetamol, which our patient took during the upper respiratory infection.…”

Section: -74mentioning

confidence: 99%

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Upper Respiratory Infection Followed by Concurrent Sweet’s Syndrome and Erythema Nodosum

Markotić

Puškarić

Skuhala

2019

Rad Hrvatske akademije znanosti i umjetnosti

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Sweet's syndrome (SS) is a rare inflammatory condition presented with fever, leukocytosis, erythematous, tender plaques and histology evidence of dense neutrophilic infiltration in the dermis. It appears mostly in women between age 30-60 years. Erythema nodosum (EN), a form of panniculitis, is manifested as erythematous painful rounded lumps and occurs 3-5 times more often in female patients in all age groups, but mostly between the second and the fourth decades of life. Although rare, concurrent occurrence of Sweet's syndrome and erythema nodosum is described and may be associated with autoimmune disorders, certain malignancies, gastrointestinal disease or upper respiratory tract infections. Here, we described 34-year-old saleswoman who developed concurrent Sweet's syndrome and erythema nodosum seven days after upper respiratory tract infection onset. During upper respiratory infection, she was treated with three-days azithromycin therapy, together with ibuprofen and paracetamol. Later, when she developed concurrent SS and EN, she was treated initially with clindamycin and prednisone 40 mg, followed by 60 mg of prednisone after which the patient becomes afebrile with gradual rash regression. There is limited knowledge on concurrent SS and EN, their etiopathogenesis and association with different diseases, infections and /or medications. Concurrent SS and EN in our patient was probably triggered by the upper respiratory tract infection. Although, there is no evidence that azithromycin may induce SS or EN or both, it could be considered as a possible trigger alone or together with the upper respiratory tract infection.

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Erythema Nodosum: A Practical Approach and Diagnostic Algorithm

et al. 2021

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Erythema nodosum is the most common form of panniculitis and is characterized by tender erythematous nodules mainly in the lower limbs on the pretibial area. The exact cause of erythema nodosum is unknown, although it appears to be a hypersensitivity response to a variety of antigenic stimuli. Although the etiology is mostly idiopathic, ruling out an underlying disease is imperative before diagnosing primary erythema nodosum. Erythema nodosum can be the first sign of a systemic disease that is triggered by a large group of processes, such as infections, inflammatory diseases, neoplasia, and/or drugs. The most common identifiable causes are streptococcal infections, primary tuberculosis, sarcoidosis, Behçet disease, inflammatory bowel disease, drugs, and pregnancy. We propose a diagnostic algorithm to optimize the initial work-up, hence initiating prompt and accurate management of the underlying disease. The algorithm includes an initial assessment of core symptoms, diagnostic work-up, differential diagnosis, and recommended therapies. Several treatment options for the erythema nodosum lesions have been previously reported; nevertheless, these options treat the symptoms, but not the triggering cause. Making an accurate diagnosis will allow the physician to treat the underlying cause and determine an optimal therapeutic strategy.

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Sweet syndrome and erythema nodosum in a case of anal canal cancer during concomitant radiochemotherapy

Cited by 4 publications

References 10 publications

Sweet syndrome in a patient with rectal adenocarcinoma and HIV following neoadjuvant chemoradiation

Sweet syndrome in a patient with rectal adenocarcinoma and HIV following neoadjuvant chemoradiation

Upper Respiratory Infection Followed by Concurrent Sweet’s Syndrome and Erythema Nodosum

Erythema Nodosum: A Practical Approach and Diagnostic Algorithm

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